Lei Yang, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Pan M, Zhang Y, Wright W, Liu X, Passaia B, Currier D, Low J, Chapple R, Steele J, Connelly J, Ju B, Plyler E, Lu M, Loughran A, Yang L, Abraham B, Pruett-Miller S, Freeman B, Campbell G, Dyer M, Chen T, Stewart E, Koo S, Sheppard H, Easton J, Geeleher P. Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid. Nature Communications 2025, 16: 2036. PMID: 40021625, PMCID: PMC11871043, DOI: 10.1038/s41467-025-57185-y.Peer-Reviewed Original ResearchConceptsRetinoic acidGenome-wide CRISPR knockout screenBone morphogenic proteinCRISPR knockout screenCell fate decisionsNeuroblastoma cellsRA-sensitive cellsNeuroblastoma patient samplesSensitive to retinoic acidKnockout screenFate decisionsNeuroblastoma cell linesCell fateBone morphogenetic proteinSignaling activityCell linesBone marrowHuman tumorsInduce differentiationMorphogenetic proteinsNormal developmentMorphogenic proteinProteinRA treatmentDifferentiationEvaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs
Actis M, Cresser-Brown J, Caine E, Steger M, Aggarwal A, Mayasundari A, Murphy N, Valinciute G, Li Y, Fu X, Yang L, Marsh G, Hughes G, Karadogan B, Wheeler D, Norley M, Spain F, Urh M, Roussel M, Schwalb B, Daub H, Riching K, Maple H, Nishiguchi G, Rankovic Z. Evaluation of Cereblon-Directing Warheads for the Development of Orally Bioavailable PROTACs. Journal Of Medicinal Chemistry 2025, 68: 3591-3611. PMID: 39813384, DOI: 10.1021/acs.jmedchem.4c02709.Peer-Reviewed Original Research
2023
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors
Koravovic M, Mayasundari A, Tasic G, Keramatnia F, Stachowski T, Cui H, Chai S, Jonchere B, Yang L, Li Y, Fu X, Hiltenbrand R, Paul L, Mishra V, Klco J, Roussel M, Pomerantz W, Fischer M, Rankovic Z, Savic V. From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. European Journal Of Medicinal Chemistry 2023, 251: 115246. PMID: 36898329, PMCID: PMC10165889, DOI: 10.1016/j.ejmech.2023.115246.Peer-Reviewed Original Research