Selected Publications

• Single-cell transcriptomic and proteomic analysis of Parkinson's disease brains.Zhu B, Park JM, Coffey SR, Russo A, Hsu IU, Wang J, Su C, Chang R, Lam TT, Gopal PP, Ginsberg SD, Zhao H, Hafler DA, Chandra SS, Zhang L. Sci Transl Med. 2024 Oct 30; 2024 Oct 30. PMID: 39475571.
• Synaptic vesicle endocytosis deficits underlie GBA-linked cognitive dysfunction in Parkinson's disease and Dementia with Lewy bodies.Vidyadhara DJ, Bäckström D, Chakraborty R, Ruan J, Park JM, Mistry PK, Chandra SS. bioRxiv. 2024 Oct 23; 2024 Oct 23. PMID: 39484386.
• Decoding transcriptomic signatures of cysteine string protein alpha-mediated synapse maintenance.Wang N, Zhu B, Allnutt MA, Grijalva RM, Zhao H, Chandra SS. Proc Natl Acad Sci U S A. 2024 Jun 11; 2024 Jun 4. PMID: 38833477.
• Impaired pre-synaptic plasticity and visual responses in auxilin-knockout mice.Cheng X, Tang Y, Vidyadhara DJ, Li BZ, Zimmerman M, Pak A, Nareddula S, Edens PA, Chandra SS, Chubykin AA. iScience. 2023 Oct 20; 2023 Sep 6. PMID: 37766983.
• Decoding transcriptomic signatures of Cysteine String Protein alpha-mediated synapse maintenance.Wang N, Zhu B, Allnutt MA, Grijalva RM, Zhao H, Chandra SS. bioRxiv. 2023 Oct 3; 2023 Oct 3. PMID: 37873460.
• α-Synuclein colocalizes with AP180 and affects the size of clathrin lattices.Vargas KJ, Colosi PL, Girardi E, Park JM, Harmon LE, Chandra SS. J Biol Chem. 2023 Sep; 2023 Jul 28. PMID: 37516240.
• Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson's disease.Vidyadhara DJ, Somayaji M, Wade N, Yücel B, Zhao H, Shashaank N, Ribaudo J, Gupta J, Lam TT, Sames D, Greene LE, Sulzer DL, Chandra SS. Cell Rep. 2023 Mar 28; 2023 Mar 14. PMID: 36920906.
• α-Synuclein Pathology and Reduced Neurogenesis in the Olfactory System Affect Olfaction in a Mouse Model of Parkinson's Disease.Martin-Lopez E, Vidyadhara DJ, Liberia T, Meller SJ, Harmon LE, Hsu RM, Spence N, Brennan B, Han K, Yücel B, Chandra SS, Greer CA. J Neurosci. 2023 Feb 8; 2023 Jan 3. PMID: 36596700.
• Pharmacological Mechanism of the Non-hallucinogenic 5-HT(2A) Agonist Ariadne and Analogs.Cunningham MJ, Bock HA, Serrano IC, Bechand B, Vidyadhara DJ, Bonniwell EM, Lankri D, Duggan P, Nazarova AL, Cao AB, Calkins MM, Khirsariya P, Hwu C, Katritch V, Chandra SS, McCorvy JD, Sames D. ACS Chem Neurosci. 2023 Jan 4; 2022 Dec 15. PMID: 36521179.
• A Markov random field model-based approach for differentially expressed gene detection from single-cell RNA-seq data.Zhu B, Li H, Zhang L, Chandra SS, Zhao H. Brief Bioinform. 2022 Sep 20. PMID: 35514182.
• Subcellular Fractionation for the Isolation of Synaptic Components from the Murine Brain.Massaro Tieze S, Chandra SS, Vidyadhara DJ. J Vis Exp. 2022 Sep 14; 2022 Sep 14. PMID: 36190269.
• Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.Gorenberg EL, Massaro Tieze S, Yücel B, Zhao HR, Chou V, Wirak GS, Tomita S, Lam TT, Chandra SS. PLoS Biol. 2022 Mar; 2022 Mar 31. PMID: 35358180.
• Hsp110 mitigates α-synuclein pathology in vivo.Taguchi YV, Gorenberg EL, Nagy M, Thrasher D, Fenton WA, Volpicelli-Daley L, Horwich AL, Chandra SS. Proc Natl Acad Sci U S A. 2019 Nov 26; 2019 Nov 4. PMID: 31685606.
• A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism.Imler E, Pyon JS, Kindelay S, Torvund M, Zhang YQ, Chandra SS, Zinsmaier KE. Elife. 2019 Oct 30; 2019 Oct 30. PMID: 31663851.
• Role of the endolysosomal system in Parkinson's disease.Vidyadhara DJ, Lee JE, Chandra SS. J Neurochem. 2019 Sep; 2019 Jul 31. PMID: 31287913.
• Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.Taguchi YV, Liu J, Ruan J, Pacheco J, Zhang X, Abbasi J, Keutzer J, Mistry PK, Chandra SS. J Neurosci. 2017 Oct 4; 2017 Aug 28. PMID: 28847804.
• The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease.Gorenberg EL, Chandra SS. Front Neurosci. 2017; 2017 May 19. PMID: 28579939.
• Synucleins Have Multiple Effects on Presynaptic Architecture.Vargas KJ, Schrod N, Davis T, Fernandez-Busnadiego R, Taguchi YV, Laugks U, Lucic V, Chandra SS. Cell Rep. 2017 Jan 3. PMID: 28052246.
• Neuronal ceroid lipofuscinosis with DNAJC5/CSPα mutation has PPT1 pathology and exhibit aberrant protein palmitoylation.Henderson MX, Wirak GS, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS. Acta Neuropathol. 2016 Apr; 2015 Dec 10. PMID: 26659577.
• Oligomerization of Cysteine String Protein alpha mutants causing adult neuronal ceroid lipofuscinosis.Zhang YQ, Chandra SS. Biochim Biophys Acta. 2014 Nov; 2014 Jul 23. PMID: 25064588.
• Synucleins regulate the kinetics of synaptic vesicle endocytosis.Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS. J Neurosci. 2014 Jul 9. PMID: 25009269.
• Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration.Bilguvar K, Tyagi NK, Ozkara C, Tuysuz B, Bakircioglu M, Choi M, Delil S, Caglayan AO, Baranoski JF, Erturk O, Yalcinkaya C, Karacorlu M, Dincer A, Johnson MH, Mane S, Chandra SS, Louvi A, Boggon TJ, Lifton RP, Horwich AL, Gunel M. Proc Natl Acad Sci U S A. 2013 Feb 26; 2013 Jan 28. PMID: 23359680.
• Monomeric synucleins generate membrane curvature.Westphal CH, Chandra SS. J Biol Chem. 2013 Jan 18; 2012 Nov 26. PMID: 23184946.
• Identification of CSPα clients reveals a role in dynamin 1 regulation.Zhang YQ, Henderson MX, Colangelo CM, Ginsberg SD, Bruce C, Wu T, Chandra SS. Neuron. 2012 Apr 12. PMID: 22500636.
• αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS. Proc Natl Acad Sci U S A. 2010 Nov 9; 2010 Oct 25. PMID: 20974939.