Skip to Main Content

Welcome to the Calderwood Laboratory

alt text

The ability of cells to sense, adhere to and remodel the extracellular matrix that surrounds them is essential for multi-cellular life. The broad goal of research in the Calderwood lab is to understand the molecular basis of signaling to and from integrin adhesion receptors. We use a combination of structural, biochemical and cell biological approaches to investigate how integrin-associated intracellular proteins regulate integrin activation state, provide links from integrins to the actin cytoskeleton, control cell migration and morphogenesis, and assemble into signaling complexes.