Publications (PubMed)

Ezrin drives adaptation of monocytes to the inflamed lung microenvironment.Gudneppanavar R, Di Pietro C, H Öz H, Zhang PX, Cheng EC, Huang PH, Tebaldi T, Biancon G, Halene S, Hoppe AD, Kim C, Gonzalez AL, Krause DS, Egan ME, Gupta N, Murray TS, Bruscia EM. Cell Death Dis. 2024 Nov 29; 2024 Nov 29. PMID: 39613751.
ENaC contributes to macrophage dysfunction in cystic fibrosis.Moran J, Pugh C, Brown N, Thomas A, Zhang S, McCauley E, Cephas A, Shrestha CL, Partida-Sanchez S, Bai S, Bruscia E, Kopp BT. bioRxiv. 2024 Nov 8; 2024 Nov 8. PMID: 39574739.
CCR2+ monocytes are dispensable to resolve acute pulmonary Pseudomonas aeruginosa infections in WT and Cystic Fibrosis mice.Öz HH, Braga CL, Gudneppanavar R, Di Pietro C, Huang PH, Zhang PX, Krause DS, Egan ME, Murray TS, Bruscia EM. J Leukoc Biol. 2024 Oct 4; 2024 Oct 4. PMID: 39365279.
Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters.Di Pietro C, Haberman AM, Lindenbach BD, Smith PC, Bruscia EM, Allore HG, Vander Wyk B, Tyagi A, Zeiss CJ. Viruses. 2024 Feb 3; 2024 Feb 3. PMID: 38400021.
The effects of elexafactor/tezafactor/ivacaftor beyond the epithelium: spurring macrophages to fight infections.Bruscia EM. Eur Respir J. 2023 Apr; 2023 Apr 1. PMID: 37003613.
Recruited monocytes/macrophages drive pulmonary neutrophilic inflammation and irreversible lung tissue remodeling in cystic fibrosis.Öz HH, Cheng EC, Di Pietro C, Tebaldi T, Biancon G, Zeiss C, Zhang PX, Huang PH, Esquibies SS, Britto CJ, Schupp JC, Murray TS, Halene S, Krause DS, Egan ME, Bruscia EM. Cell Rep. 2022 Dec 13. PMID: 36516754.
Update on Innate and Adaptive Immunity in Cystic Fibrosis.Bruscia EM, Bonfield TL. Clin Chest Med. 2022 Dec. PMID: 36344069.
Human neutrophil development and functionality are enabled in a humanized mouse model.Zheng Y, Sefik E, Astle J, Karatepe K, Öz HH, Solis AG, Jackson R, Luo HR, Bruscia EM, Halene S, Shan L, Flavell RA. Proc Natl Acad Sci U S A. 2022 Oct 25; 2022 Oct 21. PMID: 36269862.
Emerging Concepts in Defective Macrophage Phagocytosis in Cystic Fibrosis.Jaganathan D, Bruscia EM, Kopp BT. Int J Mol Sci. 2022 Jul 13; 2022 Jul 13. PMID: 35887098.
Recruitment of monocytes primed to express heme oxygenase-1 ameliorates pathological lung inflammation in cystic fibrosis.Di Pietro C, Öz HH, Zhang PX, Cheng EC, Martis V, Bonfield TL, Kelley TJ, Jubin R, Abuchowski A, Krause DS, Egan ME, Murray TS, Bruscia EM. Exp Mol Med. 2022 May; 2022 May 17. PMID: 35581352.
Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Science. 2021 Mar 5. PMID: 33674488.
Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Am J Respir Crit Care Med. 2020 Nov 15. PMID: 32603604.
Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis.Di Pietro C, Öz HH, Murray TS, Bruscia EM. Front Pharmacol. 2020; 2020 Jul 14. PMID: 32760278.
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. Nat Commun. 2019 Jan 21; 2019 Jan 21. PMID: 30664659.
Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 2018 Jan 18. PMID: 29345196.
Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages.Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM. Sci Rep. 2017 Sep 7; 2017 Sep 7. PMID: 28883468.
Cellular Innate Immunity: An Old Game with New Players.Gasteiger G, D'Osualdo A, Schubert DA, Weber A, Bruscia EM, Hartl D. J Innate Immun. 2017; 2016 Dec 23. PMID: 28006777.
Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling.Bruscia EM, Zhang PX, Barone C, Scholte BJ, Homer R, Krause DS, Egan ME. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15; 2016 Feb 5. PMID: 26851259.
Innate and Adaptive Immunity in Cystic Fibrosis.Bruscia EM, Bonfield TL. Clin Chest Med. 2016 Mar; 2015 Dec 28. PMID: 26857765.
Cystic Fibrosis Lung Immunity: The Role of the Macrophage.Bruscia EM, Bonfield TL. J Innate Immun. 2016; 2016 Jun 24. PMID: 27336915.
Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation.Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Nat Commun. 2015 Feb 10; 2015 Feb 10. PMID: 25665524.
SRF is required for neutrophil migration in response to inflammation.Taylor A, Tang W, Bruscia EM, Zhang PX, Lin A, Gaines P, Wu D, Halene S. Blood. 2014 May 8; 2014 Feb 26. PMID: 24574460.
Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung.Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS. Stem Cells. 2013 Dec. PMID: 23681901.
Disease-relevant proteostasis regulation of cystic fibrosis transmembrane conductance regulator.Villella VR, Esposito S, Bruscia EM, Vicinanza M, Cenci S, Guido S, Pettoello-Mantovani M, Carnuccio R, De Matteis MA, Luini A, Maiuri MC, Raia V, Kroemer G, Maiuri L. Cell Death Differ. 2013 Aug; 2013 May 17. PMID: 23686137.
Nebulized hyaluronan ameliorates lung inflammation in cystic fibrosis mice.Gavina M, Luciani A, Villella VR, Esposito S, Ferrari E, Bressani I, Casale A, Bruscia EM, Maiuri L, Raia V. Pediatr Pulmonol. 2013 Aug; 2012 Jul 23. PMID: 22825912.
Reduced caveolin-1 promotes hyperinflammation due to abnormal heme oxygenase-1 localization in lipopolysaccharide-challenged macrophages with dysfunctional cystic fibrosis transmembrane conductance regulator.Zhang PX, Murray TS, Villella VR, Ferrari E, Esposito S, D'Souza A, Raia V, Maiuri L, Krause DS, Egan ME, Bruscia EM. J Immunol. 2013 May 15; 2013 Apr 19. PMID: 23606537.
Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect.Villella VR, Esposito S, Bruscia EM, Maiuri MC, Raia V, Kroemer G, Maiuri L. Front Pharmacol. 2013; 2013 Jan 21. PMID: 23346057.
Nonhematopoietic cells are the primary source of bone marrow-derived lung epithelial cells.Kassmer SH, Bruscia EM, Zhang PX, Krause DS. Stem Cells. 2012 Mar. PMID: 22162244.
The carbon monoxide releasing molecule CORM-2 attenuates Pseudomonas aeruginosa biofilm formation.Murray TS, Okegbe C, Gao Y, Kazmierczak BI, Motterlini R, Dietrich LE, Bruscia EM. PLoS One. 2012; 2012 Apr 26. PMID: 22563385.
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.Bruscia EM, Zhang PX, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. J Immunol. 2011 Jun 15; 2011 May 18. PMID: 21593379.
Role for MKL1 in megakaryocytic maturation.Cheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS. Blood. 2009 Mar 19; 2009 Jan 9. PMID: 19136660.
Macrophages directly contribute to the exaggerated inflammatory response in cystic fibrosis transmembrane conductance regulator-/- mice.Bruscia EM, Zhang PX, Ferreira E, Caputo C, Emerson JW, Tuck D, Krause DS, Egan ME. Am J Respir Cell Mol Biol. 2009 Mar; 2008 Sep 5. PMID: 18776130.
Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models.Weiner SA, Caputo C, Bruscia E, Ferreira EC, Price JE, Krause DS, Egan ME. Pediatr Res. 2008 Jan. PMID: 18043508.
Cftr gene targeting in mouse embryonic stem cells mediated by Small Fragment Homologous Replacement (SFHR).Sangiuolo F, Scaldaferri ML, Filareto A, Spitalieri P, Guerra L, Favia M, Caroppo R, Mango R, Bruscia E, Gruenert DC, Casavola V, De Felici M, Novelli G. Front Biosci. 2008 Jan 1; 2008 Jan 1. PMID: 17981772.
Engraftment of donor-derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice.Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. Stem Cells. 2006 Oct; 2006 Jun 22. PMID: 16794262.
Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice after bone marrow transplantation.Bruscia EM, Price JE, Cheng EC, Weiner S, Caputo C, Ferreira EC, Egan ME, Krause DS. Proc Natl Acad Sci U S A. 2006 Feb 21; 2006 Feb 15. PMID: 16481627.
In vitro restoration of functional SMN protein in human trophoblast cells affected by spinal muscular atrophy by small fragment homologous replacement.Sangiuolo F, Filareto A, Spitalieri P, Scaldaferri ML, Mango R, Bruscia E, Citro G, Brunetti E, De Felici M, Novelli G. Hum Gene Ther. 2005 Jul. PMID: 16000068.
Engraftment of bone marrow-derived epithelial cells.Van Arnam JS, Herzog E, Grove J, Bruscia E, Ziegler E, Swenson S, Krause DS. Stem Cell Rev. 2005. PMID: 17132871.
Lack of a fusion requirement for development of bone marrow-derived epithelia.Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Science. 2004 Jul 2. PMID: 15232107.
Oligonucleotide-based gene targeting approaches.Gruenert DC, Kunzelmann K, Novelli G, Colosimo A, Kapsa R, Bruscia E. Oligonucleotides. 2004. PMID: 15294078.
Plasticity of bone marrow-derived stem cells.Grove JE, Bruscia E, Krause DS. Stem Cells. 2004. PMID: 15277695.
Sequence-specific modification of genomic DNA by small DNA fragments.Gruenert DC, Bruscia E, Novelli G, Colosimo A, Dallapiccola B, Sangiuolo F, Goncz KK. J Clin Invest. 2003 Sep. PMID: 12952908.
In vitro correction of cystic fibrosis epithelial cell lines by small fragment homologous replacement (SFHR) technique.Sangiuolo F, Bruscia E, Serafino A, Nardone AM, Bonifazi E, Lais M, Gruenert DC, Novelli G. BMC Med Genet. 2002 Sep 23; 2002 Sep 23. PMID: 12243649.
Towards the pharmacogenomics of cystic fibrosis.Sangiuolo F, D'Apice MR, Bruscia E, Lucidi V, Novelli G. Pharmacogenomics. 2002 Jan. PMID: 11966405.

Additional Publications

Hartl D, Gaggar A, Bruscia E, Hector A, Marcos V, Jung A, Greene C, McElvaney G, Mall M, Döring G. Innate immunity in cystic fibrosis lung disease. J Cyst Fibros. 2012 Aug 20. PMID: 22917571 (review)
Gavina M, Luciani A, Villella VR, Esposito S, Ferrari E, Bressani I, Casale A, Bruscia EM, Maiuri L and Raia V. Nebulized Hyaluronan Ameliorates Lung Inflammation in Cystic Fibrosis Mice. Pediatric Pulmonology. 2012 Jul 23. doi: 10.1002/ppul.22637.
Bruscia EM, Sangiuolo F, Sinibaldi P, Goncz KK, Novelli G, Gruenert DC. Isolation of CF cell lines corrected at DeltaF508-CFTR locus by SFHR-mediated targeting. Gene Ther. 2002 Jun;9(11):683-5.
Sangiuolo F, Bruscia EM, Capon F, Servidei S, Dallapiccola B, Novelli G. Fine mapping of a distinctive autosomal dominant vacuolar neuromyopathy using 11 novel microsatellite markers from chromosome band 19p13.3. Eur J Hum Genet. 2000 Oct;8(10):809-12.
Colosimo A, Serafino A, Sangiuolo F, Di Sario S, Bruscia EM, Amicucci P, Novelli G, Dallapiccola B, Mossa G. Gene transfection efficiency of tracheal epithelial cells by DC-chol-DOPE/DNA complexes. Biochim Biophys Acta. 1999 Jul 15;1419(2):186-94.
Semprini S, Capon F, Bovolenta S, Bruscia EM, Pizzuti A, Fabrizi G, Schietroma C, Zambruno G, Dallapiccola B, Novelli G. Genomic structure, promoter characterization and mutational analysis of the S100A7 gene: exclusion of a candidate for familial psoriasis susceptibility. Hum Genet. 1999 Feb;104:130-4.