2023
Mapping Lesion-Related Epilepsy to a Human Brain Network
Schaper F, Nordberg J, Cohen A, Lin C, Hsu J, Horn A, Ferguson M, Siddiqi S, Drew W, Soussand L, Winkler A, Simó M, Bruna J, Rheims S, Guenot M, Bucci M, Nummenmaa L, Staals J, Colon A, Ackermans L, Bubrick E, Peters J, Wu O, Rost N, Grafman J, Blumenfeld H, Temel Y, Rouhl R, Joutsa J, Fox M. Mapping Lesion-Related Epilepsy to a Human Brain Network. JAMA Neurology 2023, 80: 891-902. PMID: 37399040, PMCID: PMC10318550, DOI: 10.1001/jamaneurol.2023.1988.Peer-Reviewed Original ResearchConceptsRisk of epilepsyLesion locationBrain regionsPoststroke epilepsyControl patientsSeizure controlBrain lesionsIndependent cohortBrain networksLesion typeBrain stimulation sitesLesion network mappingLesion-related epilepsyImproved seizure controlDrug-resistant epilepsyCase-control studyBrain stimulation therapyHuman brain networksSpecific brain regionsDifferent lesion typesSpecific brain networksBasal gangliaVascular territoriesStimulation therapyMAIN OUTCOME
2016
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.Peer-Reviewed Original ResearchConceptsAbsence seizuresCross-sectional studyFMRI amplitudeFunctional MRIBehavioral impairmentsJuvenile absence epilepsyBilateral spike-wave dischargesOnset of seizuresPediatric neurology practiceNational InstituteSpike-wave dischargesPhysiological changesBehavioral responsesDefault mode networkImpaired task performanceSeizure durationImpaired consciousnessElectroencephalography changesNeurology practiceAbsence epilepsyFMRI changesBehavioral deficitsMAIN OUTCOMEBehavioral testingEEG changes