Publications

Textbooks

Review Articles

"Impaired consciousness in epilepsy." (Lancet Neurology, 2012).

"Arousal and Consciousness in Focal Seizures" (Epilepsy Currents, 2021).

"Brain Mechanisms of Conscious Awareness: Detect, Pulse, Switch, and Wave" (Neuroscientist, 2023).

Publications

Featured Publications

Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.
Peer-Reviewed Original Research
MeSH Keywords
Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity
Kronemer S, Aksen M, Ding J, Ryu J, Xin Q, Ding Z, Prince J, Kwon H, Forman S, Jin D, Wang K, Chen K, Hu C, Agarwal A, Saberski E, Wafa S, Morgan O, Wu J, Hasulak N, Morrell M, Urban A, Todd Constable R, Pitts M, Mark Richardson R, Crowley M, Blumenfeld H. Human visual consciousness involves large scale cortical and subcortical networks independent of task report and eye movement activity. Nature Communications 2022, 13: 7342. PMID: 36446792, PMCID: PMC9707162, DOI: 10.1038/s41467-022-35117-4.
Peer-Reviewed Original Research
MeSH Keywords
The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention
Li R, Ryu JH, Vincent P, Springer M, Kluger D, Levinsohn EA, Chen Y, Chen H, Blumenfeld H. The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention. NeuroImage 2021, 232: 117873. PMID: 33647499, PMCID: PMC8278331, DOI: 10.1016/j.neuroimage.2021.117873.
Peer-Reviewed Original Research
MeSH Keywords
A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception
Herman WX, Smith RE, Kronemer SI, Watsky RE, Chen WC, Gober LM, Touloumes GJ, Khosla M, Raja A, Horien CL, Morse EC, Botta KL, Hirsch LJ, Alkawadri R, Spencer DD, Blumenfeld H. A Switch and Wave of Neuronal Activity in the Cerebral Cortex During the First Second of Conscious Perception. Cerebral Cortex 2017, 29: 461-474. PMID: 29194517, PMCID: PMC6319177, DOI: 10.1093/cercor/bhx327.
Peer-Reviewed Original Research
MeSH Keywords
Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation
Gummadavelli A, Ma C, Liu M, McCafferty C, Schiff ND, Willie JT, Gross RE, Blumenfeld H. Restoring Conscious Arousal During Focal Limbic Seizures with Deep Brain Stimulation. Cerebral Cortex 2016, 27: 1964-1975. PMID: 26941379, PMCID: PMC5964488, DOI: 10.1093/cercor/bhw035.
Peer-Reviewed Original Research
MeSH Keywords
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.
Peer-Reviewed Original Research
MeSH Keywords
Decreased Subcortical Cholinergic Arousal in Focal Seizures
Motelow JE, Li W, Zhan Q, Mishra AM, Sachdev RN, Liu G, Gummadavelli A, Zayyad Z, Lee HS, Chu V, Andrews JP, Englot DJ, Herman P, Sanganahalli BG, Hyder F, Blumenfeld H. Decreased Subcortical Cholinergic Arousal in Focal Seizures. Neuron 2015, 85: 561-572. PMID: 25654258, PMCID: PMC4319118, DOI: 10.1016/j.neuron.2014.12.058.
Peer-Reviewed Original Research
MeSH Keywords
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.
Peer-Reviewed Original Research
MeSH Keywords
Early cortical signals in visual stimulus detection
Kwon H, Kronemer SI, Li J, Ding JZ, Freedman NC, Blumenfeld H. Early cortical signals in visual stimulus detection. NeuroImage 2021, 244: 118608. PMID: 34560270, DOI: 10.1016/j.neuroimage.2021.118608.
Peer-Reviewed Original Research
MeSH Keywords
Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures
Blumenfeld H, Varghese GI, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch LJ, Tikofsky R, Zubal IG, Paige AL, Spencer SS. Cortical and subcortical networks in human secondarily generalized tonic–clonic seizures. Brain 2009, 132: 999-1012. PMID: 19339252, PMCID: PMC2724910, DOI: 10.1093/brain/awp028.
Peer-Reviewed Original Research
MeSH Keywords
Early treatment suppresses the development of spike‐wave epilepsy in a rat model
Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul‐Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J, Nersesyan H, Waxman SG, Levin AR. Early treatment suppresses the development of spike‐wave epilepsy in a rat model. Epilepsia 2007, 49: 400-409. PMID: 18070091, PMCID: PMC3143182, DOI: 10.1111/j.1528-1167.2007.01458.x.
Peer-Reviewed Original Research
MeSH Keywords

2026

Neural mechanisms of awareness of action
Jin D, Agdali O, Yadav T, Kronemer S, Kunkler S, Majumder S, Khurana M, McCusker M, Fu I, Siff E, Aerts S, Xin Q, Li J, McGill S, Crowley M, Blumenfeld H. Neural mechanisms of awareness of action. PNAS Nexus 2026, 5: pgag220. PMID: 42416922, PMCID: PMC13340929, DOI: 10.1093/pnasnexus/pgag220.
Peer-Reviewed Original Research
An open-access multi-site fMRI dataset for investigating conscious visual perception
Khalaf A, Richter D, Vidal Y, Gorska-Klimowska U, Hirschhorn R, Das D, Kahraman K, Sripad P, Taheriyan F, Mudrik L, Pitts M, Blumenfeld H, de Lange F, Bonacchi N, Brown T, Melloni L. An open-access multi-site fMRI dataset for investigating conscious visual perception. Scientific Data 2026, 13: 779. PMID: 42115661, PMCID: PMC13213011, DOI: 10.1038/s41597-026-07377-y.
Peer-Reviewed Original Research
MeSH Keywords

2025

Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse
McGill S, Xin Q, Yadav T, Zhao C, Paszkowski P, Darby F, Guha M, Nguyen T, Jin D, Nir Y, Liu J, Blumenfeld H. Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse. PLOS ONE 2025, 20: e0334293. PMID: 41144455, PMCID: PMC12558558, DOI: 10.1371/journal.pone.0334293.
Peer-Reviewed Original Research
MeSH Keywords
A practical guide to the updated seizure classification 2025
Beniczky S, Trinka E, Wirrell E, Singh M, Blumenfeld H, Fressola A, Cendes F, Craiu D, Frauscher B, Jansen F, Kahane P, Kander V, Kishk N, Khoo C, Lizcano A, De Palma L, Ryvlin P, Specchio N, Sperling M, Tatum W, Yacubian E, Wilmshurst J, Cross J. A practical guide to the updated seizure classification 2025. Epileptic Disorders 2025, 27: 1087-1104. PMID: 41081650, PMCID: PMC12747708, DOI: 10.1002/epd2.70110.
Peer-Reviewed Original Research
Revidierte Klassifikation epileptischer Anfälle: Positionspapier der Internationalen Liga gegen Epilepsie
Beniczky S, Trinka E, Wirrell E, Abdulla F, Al Baradie R, Alonso Vanegas M, Auvin S, Singh M, Blumenfeld H, Bogacz Fressola A, Caraballo R, Carreno M, Cendes F, Charway A, Cook M, Craiu D, Ezeala-Adikaibe B, Frauscher B, French J, Gule M, Higurashi N, Ikeda A, Jansen F, Jobst B, Kahane P, Kishk N, Khoo C, Vinayan K, Lagae L, Lim K, Lizcano A, McGonigal A, Perez-Gosiengfiao K, Ryvlin P, Specchio N, Sperling M, Stefan H, Tatum W, Tripathi M, Yacubian E, Wiebe S, Wilmshurst J, Zhou D, Cross J. Revidierte Klassifikation epileptischer Anfälle: Positionspapier der Internationalen Liga gegen Epilepsie. Clinical Epileptology 2025, 38: 278-295. DOI: 10.1007/s10309-025-00789-7.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Digital Response Test in Epilepsy assesses interictal epileptiform discharge effects in real time
von Allmen A, Lu D, Jagella C, Abukhadra Y, Markhus R, Triesch J, Gopaul M, Hirsch L, Rosenow F, Blumenfeld H, Krestel H. Digital Response Test in Epilepsy assesses interictal epileptiform discharge effects in real time. Epilepsia 2025, 67: 381-395. PMID: 41042536, PMCID: PMC12893249, DOI: 10.1111/epi.18629.
Peer-Reviewed Original Research
Decreased cholinergic neuronal firing in a mouse model of temporal lobe seizures with impaired consciousness
Liu S, Paszkowski P, Qu J, Liu J, Valcarce‐Aspegren M, Khan W, McGill S, Lee D, Duque A, Blumenfeld H. Decreased cholinergic neuronal firing in a mouse model of temporal lobe seizures with impaired consciousness. Epilepsia 2025, 66: 5067-5081. PMID: 40956639, DOI: 10.1111/epi.18625.
Peer-Reviewed Original Research
Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures
Salardini E, Vaddiparti A, Kumar A, Qu J, Martin R, Arencibia C, Dhakar M, Grover E, Quraishi I, Sternberg E, George I, Sivaraju A, Bonito J, Zaveri H, Gober L, Ahammad S, Ghoshal S, Wu K, Hirsch L, Damisah E, Gerrard J, Spencer D, Young J, Friedman D, Shum J, Blumenfeld H. Relationship Between Brain Activity and Impaired Consciousness in Frontal Lobe Seizures. Neurology 2025, 105: e213965. PMID: 40893057, PMCID: PMC12406365, DOI: 10.1212/wnl.0000000000213965.
Peer-Reviewed Original Research
MeSH Keywords
Effects of Centromedian Nucleus Stimulation on Interictal Scalp EEG Burden in Lennox-Gastaut Syndrome
Sivaraju A, Poe J, Blumenfeld H, Cukiert A. Effects of Centromedian Nucleus Stimulation on Interictal Scalp EEG Burden in Lennox-Gastaut Syndrome. Stereotactic And Functional Neurosurgery 2025, 104: 36-41. PMID: 40889229, DOI: 10.1159/000548242.
Peer-Reviewed Original Research
Distinct spike‐and‐wave EEG profiles reveal susceptibility to fleeting/almost loss of consciousness (so‐called blips) in generalized epilepsy
Matringe E, Granchamp R, Vidal J, Perrone‐Bertolotti M, Blumenfeld H, Vercueil L. Distinct spike‐and‐wave EEG profiles reveal susceptibility to fleeting/almost loss of consciousness (so‐called blips) in generalized epilepsy. Epilepsia 2025, 66: 4465-4475. PMID: 40736396, PMCID: PMC12661269, DOI: 10.1111/epi.18557.
Peer-Reviewed Original Research
Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging
Herman P, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Verhagen J, Blumenfeld H, Hyder F. Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging. Cerebral Cortex 2025, 35: bhaf165. PMID: 40624899, PMCID: PMC13070531, DOI: 10.1093/cercor/bhaf165.
Peer-Reviewed Original Research
MeSH Keywords
Adversarial testing of global neuronal workspace and integrated information theories of consciousness
Ferrante O, Gorska-Klimowska U, Henin S, Hirschhorn R, Lepauvre A, Liu L, Richter D, Vidal Y, Bonacchi N, Brown T, Sripad P, Armendariz M, Bendtz K, Ghafari T, Hetenyi D, Jeschke J, Kozma C, Mazumder D, Montenegro S, Seedat A, Sharafeldin A, Yang S, Baillet S, Chalmers D, Cichy R, Fallon F, Panagiotaropoulos T, Blumenfeld H, de Lange F, Devore S, Jensen O, Kreiman G, Luo H, Boly M, Dehaene S, Koch C, Tononi G, Pitts M, Mudrik L, Melloni L. Adversarial testing of global neuronal workspace and integrated information theories of consciousness. Nature 2025, 642: 133-142. PMID: 40307561, PMCID: PMC12137136, DOI: 10.1038/s41586-025-08888-1.
Peer-Reviewed Original Research
MeSH Keywords
Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy
Beniczky S, Trinka E, Wirrell E, Abdulla F, Al Baradie R, Vanegas M, Auvin S, Singh M, Blumenfeld H, Fressola A, Caraballo R, Carreno M, Cendes F, Charway A, Cook M, Craiu D, Ezeala‐Adikaibe B, Frauscher B, French J, Gule M, Higurashi N, Ikeda A, Jansen F, Jobst B, Kahane P, Kishk N, Khoo C, Vinayan K, Lagae L, Lim K, Lizcano A, McGonigal A, Perez‐Gosiengfiao K, Ryvlin P, Specchio N, Sperling M, Stefan H, Tatum W, Tripathi M, Yacubian E, Wiebe S, Wilmshurst J, Zhou D, Cross J. Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy. Epilepsia 2025, 66: 1804-1823. PMID: 40264351, PMCID: PMC12169392, DOI: 10.1111/epi.18338.
Peer-Reviewed Original Research
MeSH Keywords
Shared subcortical arousal systems across sensory modalities during transient modulation of attention
Lopez E, Li J, Horn A, Edlow B, Blumenfeld H. Shared subcortical arousal systems across sensory modalities during transient modulation of attention. NeuroImage 2025, 312: 121224. PMID: 40250641, PMCID: PMC12351731, DOI: 10.1016/j.neuroimage.2025.121224.
Peer-Reviewed Original Research
MeSH Keywords

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