2024
Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy
Khan W, Chopra S, Zheng X, Liu S, Paszkowski P, Valcarce-Aspegren M, Sieu L, Mcgill S, Mccafferty C, Blumenfeld H. Neuronal rhythmicity and cortical arousal in a mouse model of absence epilepsy. Experimental Neurology 2024, 381: 114925. PMID: 39151596, DOI: 10.1016/j.expneurol.2024.114925.Peer-Reviewed Original ResearchExtracellular single unit recordingsSingle unit recordingsMouse modelNeuronal firingAbsence epilepsyFiring patternsRat modelSeizure initiationMouse model of absence epilepsyIn vivo extracellular single unit recordingNeuronal activityUnit recordingsModel of absence epilepsySomatosensory barrel cortexC3H/HeJ mouse modelNeuronal firing rateHuman absence epilepsyDiverse firing patternsNeuronal rhythmicityArousal stateC3H/HeJ miceBarrel cortexStudy of neuronal activityCortical electroencephalographyFiring rate
2022
A machine‐learning approach for predicting impaired consciousness in absence epilepsy
Springer M, Khalaf A, Vincent P, Ryu JH, Abukhadra Y, Beniczky S, Glauser T, Krestel H, Blumenfeld H. A machine‐learning approach for predicting impaired consciousness in absence epilepsy. Annals Of Clinical And Translational Neurology 2022, 9: 1538-1550. PMID: 36114696, PMCID: PMC9539371, DOI: 10.1002/acn3.51647.Peer-Reviewed Original Research
2016
Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study
Guo JN, Kim R, Chen Y, Negishi M, Jhun S, Weiss S, Ryu JH, Bai X, Xiao W, Feeney E, Rodriguez-Fernandez J, Mistry H, Crunelli V, Crowley MJ, Mayes LC, Constable RT, Blumenfeld H. Impaired consciousness in patients with absence seizures investigated by functional MRI, EEG, and behavioural measures: a cross-sectional study. The Lancet Neurology 2016, 15: 1336-1345. PMID: 27839650, PMCID: PMC5504428, DOI: 10.1016/s1474-4422(16)30295-2.Peer-Reviewed Original ResearchConceptsAbsence seizuresCross-sectional studyFMRI amplitudeFunctional MRIBehavioral impairmentsJuvenile absence epilepsyBilateral spike-wave dischargesOnset of seizuresPediatric neurology practiceNational InstituteSpike-wave dischargesPhysiological changesBehavioral responsesDefault mode networkImpaired task performanceSeizure durationImpaired consciousnessElectroencephalography changesNeurology practiceAbsence epilepsyFMRI changesBehavioral deficitsMAIN OUTCOMEBehavioral testingEEG changes
2011
Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat
Mishra AM, Ellens DJ, Schridde U, Motelow JE, Purcaro MJ, DeSalvo MN, Enev M, Sanganahalli BG, Hyder F, Blumenfeld H. Where fMRI and Electrophysiology Agree to Disagree: Corticothalamic and Striatal Activity Patterns in the WAG/Rij Rat. Journal Of Neuroscience 2011, 31: 15053-15064. PMID: 22016539, PMCID: PMC3432284, DOI: 10.1523/jneurosci.0101-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingBrain WavesCerebral CortexCerebrovascular CirculationCorpus StriatumDisease Models, AnimalElectroencephalographyElectrophysiologyEpilepsyImage Processing, Computer-AssistedLaser-Doppler FlowmetryMagnetic Resonance ImagingNicotinic AntagonistsOxygenRatsRats, WistarThalamusTubocurarineVibrissaeConceptsCerebral blood flowCerebral blood volumeLocal field potentialsNeuronal activityLaser Doppler cerebral blood flowSubcortical structuresWAG/Rij ratsNeuronal activity decreasesHuman absence epilepsySpike-wave dischargesWAG/RijMultiunit activity recordingsFMRI signalsFunctional magnetic resonance imaging (fMRI) signalsMagnetic resonance imaging signalsFMRI decreasesCBF decreaseHemodynamic changesCerebral cortexBasal gangliaSomatosensory cortexAbsence epilepsyWhisker stimulationBlood flowAnimal models