Publications

Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.Hoang H, Lacadie C, Hwang J, Lam K, Elshafie A, Rosenberg SB, Watt C, Sinha R, Constable RT, Savoye M, Seo D, Belfort-DeAguiar R. Obesity (Silver Spring). 2024 Jul; 2024 Jun 3. PMID: 38831482.
A multisociety Delphi consensus statement on new fatty liver disease nomenclature.Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN. Hepatology. 2023 Dec 1; 2023 Jun 24. PMID: 37363821.
A global research priority agenda to advance public health responses to fatty liver disease.Lazarus JV, Mark HE, Allen AM, Arab JP, Carrieri P, Noureddin M, Alazawi W, Alkhouri N, Alqahtani SA, Arrese M, Bataller R, Berg T, Brennan PN, Burra P, Castro-Narro GE, Cortez-Pinto H, Cusi K, Dedes N, Duseja A, Francque SM, Hagström H, Huang TT, Wajcman DI, Kautz A, Kopka CJ, Krag A, Miller V, Newsome PN, Rinella ME, Romero D, Sarin SK, Silva M, Spearman CW, Tsochatzis EA, Valenti L, Villota-Rivas M, Zelber-Sagi S, Schattenberg JM, Wong VW, Younossi ZM. J Hepatol. 2023 Sep; 2023 Jun 20. PMID: 37353401.
Approach to the Patient With Nonalcoholic Fatty Liver Disease.Belfort-DeAguiar R, Lomonaco R, Cusi K. J Clin Endocrinol Metab. 2023 Jan 17. PMID: 36305273.
PPAR-γ-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH.Gastaldelli A, Sabatini S, Carli F, Gaggini M, Bril F, Belfort-DeAguiar R, Positano V, Barb D, Kadiyala S, Harrison S, Cusi K. Liver Int. 2021 Nov; 2021 Jul 21. PMID: 34219361.
Implementing a pharmacist-led transition of care model for posttransplant hyperglycemia.Do V, Haakinson D, Belfort-DeAguiar R, Cohen E. Am J Health Syst Pharm. 2021 Jun 23. PMID: 33821878.
Norepinephrine transporter availability in brown fat is reduced in obesity: a human PET study with [(11)C] MRB.Sanchez-Rangel E, Gallezot JD, Yeckel CW, Lam W, Belfort-DeAguiar R, Chen MK, Carson RE, Sherwin R, Hwang JJ. Int J Obes (Lond). 2020 Apr; 2019 Oct 21. PMID: 31636373.
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes.Parikh L, Seo D, Lacadie C, Belfort-Deaguiar R, Groskreutz D, Hamza M, Dai F, Scheinost D, Sinha R, Todd Constable R, Sherwin R, Hwang JJ. J Clin Endocrinol Metab. 2020 Jan 1. PMID: 31511876.
In a Free-Living Setting, Obesity Is Associated With Greater Food Intake in Response to a Similar Premeal Glucose Nadir.Kim J, Lam W, Wang Q, Parikh L, Elshafie A, Sanchez-Rangel E, Schmidt C, Li F, Hwang J, Belfort-DeAguiar R. J Clin Endocrinol Metab. 2019 Sep 1. PMID: 31087061.
CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.
Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation.Belfort-DeAguiar R, Seo D. Curr Obes Rep. 2018 Jun. PMID: 29619632.
Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia.Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. J Clin Endocrinol Metab. 2018 Jun 1. PMID: 29590401.
Humans with obesity have disordered brain responses to food images during physiological hyperglycemia.Belfort-DeAguiar R, Seo D, Lacadie C, Naik S, Schmidt C, Lam W, Hwang J, Constable T, Sinha R, Sherwin RS. Am J Physiol Endocrinol Metab. 2018 May 1; 2018 Jan 30. PMID: 29381374.
Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia.Hwang JJ, Parikh L, Lacadie C, Seo D, Lam W, Hamza M, Schmidt C, Dai F, Sejling AS, Belfort-DeAguiar R, Constable RT, Sinha R, Sherwin R. J Clin Invest. 2018 Apr 2; 2018 Mar 5. PMID: 29381484.
Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM.Hwang JJ, Jiang L, Hamza M, Sanchez Rangel E, Dai F, Belfort-DeAguiar R, Parikh L, Koo BB, Rothman DL, Mason G, Sherwin RS. JCI Insight. 2017 Oct 19; 2017 Oct 19. PMID: 29046482.
Evaluation of the counter-regulatory responses to hypoglycaemia in patients with type 1 diabetes during opiate receptor blockade with naltrexone.Naik S, Belfort-DeAguiar R, Sejling AS, Szepietowska B, Sherwin RS. Diabetes Obes Metab. 2017 May; 2017 Feb 17. PMID: 27987236.
The human brain produces fructose from glucose.Hwang JJ, Jiang L, Hamza M, Dai F, Belfort-DeAguiar R, Cline G, Rothman DL, Mason G, Sherwin RS. JCI Insight. 2017 Feb 23; 2017 Feb 23. PMID: 28239653.
Food image-induced brain activation is not diminished by insulin infusion.Belfort-DeAguiar R, Seo D, Naik S, Hwang J, Lacadie C, Schmidt C, Constable RT, Sinha R, Sherwin R. Int J Obes (Lond). 2016 Nov; 2016 Aug 29. PMID: 27569684.
Inhaled Formoterol Diminishes Insulin-Induced Hypoglycemia in Type 1 Diabetes.Belfort-DeAguiar RD, Naik S, Hwang J, Szepietowska B, Sherwin RS. Diabetes Care. 2015 Sep; 2015 Jul 7. PMID: 26153273.
Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women.Hwang JJ, Johnson A, Cline G, Belfort-DeAguiar R, Snegovskikh D, Khokhar B, Han CS, Sherwin RS. PLoS One. 2015; 2015 Jun 2. PMID: 26035307.
Functional MRI signal fluctuations: a preclinical biomarker for cognitive impairment in type 2 diabetes?Belfort-Deaguiar R, Constable RT, Sherwin RS. Diabetes. 2014 Feb. PMID: 24464717.
Increased brain transport and metabolism of acetate in hypoglycemia unawareness.Gulanski BI, De Feyter HM, Page KA, Belfort-DeAguiar R, Mason GF, Rothman DL, Sherwin RS. J Clin Endocrinol Metab. 2013 Sep; 2013 Jun 24. PMID: 23796565.
Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways.Page KA, Chan O, Arora J, Belfort-Deaguiar R, Dzuira J, Roehmholdt B, Cline GW, Naik S, Sinha R, Constable RT, Sherwin RS. JAMA. 2013 Jan 2. PMID: 23280226.
Circulating glucose levels modulate neural control of desire for high-calorie foods in humans.Page KA, Seo D, Belfort-DeAguiar R, Lacadie C, Dzuira J, Naik S, Amarnath S, Constable RT, Sherwin RS, Sinha R. J Clin Invest. 2011 Oct; 2011 Sep 19. PMID: 21926468.
Fenofibrate reduces systemic inflammation markers independent of its effects on lipid and glucose metabolism in patients with the metabolic syndrome.Belfort R, Berria R, Cornell J, Cusi K. J Clin Endocrinol Metab. 2010 Feb; 2010 Jan 8. PMID: 20061429.
Chronic low-dose lipid infusion in healthy patients induces markers of endothelial activation independent of its metabolic effects.Kashyap SR, Belfort R, Cersosimo E, Lee S, Cusi K. J Cardiometab Syndr. 2008 Summer. PMID: 18983329.
Pioglitazone treatment increases whole body fat but not total body water in patients with non-alcoholic steatohepatitis.Balas B, Belfort R, Harrison SA, Darland C, Finch J, Schenker S, Gastaldelli A, Cusi K. J Hepatol. 2007 Oct; 2007 May 24. PMID: 17560678.
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli A, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S, Cusi K. N Engl J Med. 2006 Nov 30. PMID: 17135584.
Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome.Berria R, Gastaldelli A, Lucidi S, Belfort R, De Filippis E, Easton C, Brytzki R, Cusi K, Jovanovic L, DeFronzo R. Clin Pharmacol Ther. 2006 Aug; 2006 Jun 30. PMID: 16890572.
Increased collagen content in insulin-resistant skeletal muscle.Berria R, Wang L, Richardson DK, Finlayson J, Belfort R, Pratipanawatr T, De Filippis EA, Kashyap S, Mandarino LJ. Am J Physiol Endocrinol Metab. 2006 Mar; 2005 Oct 25. PMID: 16249255.
Dose-response effect of elevated plasma free fatty acid on insulin signaling.Belfort R, Mandarino L, Kashyap S, Wirfel K, Pratipanawatr T, Berria R, Defronzo RA, Cusi K. Diabetes. 2005 Jun. PMID: 15919784.
Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.Kashyap SR, Roman LJ, Lamont J, Masters BS, Bajaj M, Suraamornkul S, Belfort R, Berria R, Kellogg DL Jr, Liu Y, DeFronzo RA. J Clin Endocrinol Metab. 2005 Feb; 2004 Nov 23. PMID: 15562034.
Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects.Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, Mandarino LJ. Metabolism. 2004 Sep. PMID: 15334390.
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes.Kashyap SR, Belfort R, Berria R, Suraamornkul S, Pratipranawatr T, Finlayson J, Barrentine A, Bajaj M, Mandarino L, DeFronzo R, Cusi K. Am J Physiol Endocrinol Metab. 2004 Sep; 2004 May 4. PMID: 15126243.
Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action.Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Mandarino LJ. J Appl Physiol (1985). 2003 Dec; 2003 Aug 8. PMID: 12909611.
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K. Diabetes. 2003 Oct. PMID: 14514628.
Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans.Bajaj M, Berria R, Pratipanawatr T, Kashyap S, Pratipanawatr W, Belfort R, Cusi K, Mandarino L, DeFronzo RA. Am J Physiol Endocrinol Metab. 2002 Aug. PMID: 12110541.
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects.Pratipanawatr T, Pratipanawatr W, Rosen C, Berria R, Bajaj M, Cusi K, Mandarino L, Kashyap S, Belfort R, DeFronzo RA. Am J Physiol Endocrinol Metab. 2002 Jun. PMID: 12006367.