YCAAD Research Program

Credit: Robert A. Lisak

Laboratory scientist, Susan He, plays a crucial role in research. She performs complex biological tests on numerous blood and sputum samples supplied by voluntary subjects. By utilizing microscopes, cell counters, and other sophisticated laboratory equipment, Susan is able to analyze the samples and relay the resulting data to physicians so they have an improved vision of how to deal with the disease.

Yale-New Haven Hospital is the largest referral center in the state and YCAAD is the only dedicated adult asthma center in the region. The Center receives over 3000 visits a year and is the hub of the clinical/translational research program at Yale. As Director of YCAAD, Dr. Geoffrey Chupp has developed a clinical research protocol, The Mechanisms and Mediators of Asthma and COPD (HIC 12268), that has recruited over 400 airway disease subjects to donate samples to the YCAAD repository and participate in YCAAD research activities. The evolution of this research protocol dovetailed with the clinical program, creating a unique system that efficiently recruits patients into clinical study protocols. This protocol has resulted in the development of a large sample repository of clinical and physiologic data, DNA, plasma and lung specimens from asthmatics that are stable or flaring (including the intensive care unit). All the data is uploaded into a powerful web-based database. The information enters the system in real-time and is used to advance the understanding of the causes of Asthma and Airway Disease.

Publications

Sputum alarmins delineate distinct T2 cytokine pathways and unique subtypes of patients with asthma.Gautam S, Chu JH, Cohen AJ, Kaur R, Lee S, Wilson G, Liu Q, Gomez J, Rajaveen H, Yan X, Cohn L, Clark BJ, Chupp GL. Allergy. 2023 Dec; 2023 Oct 24. PMID: 37874609.
Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19.Liu Y, Rajeevan H, Simonov M, Lee S, Wilson FP, Desir GV, Vinetz JM, Yan X, Wang Z, Clark BJ, Possick JD, Price C, Lutchmansingh DD, Ortega H, Zaeh S, Gomez JV, Cohn L, Gautam S, Chupp GL. J Allergy Clin Immunol Pract. 2023 Nov; 2023 Jul 14. PMID: 37454926.
SPLUNC1: a novel marker of cystic fibrosis exacerbations.Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 Nov; 2021 Nov 11. PMID: 33958427.
A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future.Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. Chest. 2021 Mar; 2020 Nov 4. PMID: 33159907.
A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. Am J Respir Crit Care Med. 2020 Jul 1. PMID: 32255668.
An endothelial microRNA-1-regulated network controls eosinophil trafficking in asthma and chronic rhinosinusitis.Korde A, Ahangari F, Haslip M, Zhang X, Liu Q, Cohn L, Gomez JL, Chupp G, Pober JS, Gonzalez A, Takyar SS. J Allergy Clin Immunol. 2020 Feb. PMID: 32035607.
Characterisation of asthma subgroups associated with circulating YKL-40 levels.Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL. Eur Respir J. 2017 Oct; 2017 Oct 12. PMID: 29025889.
Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.Chupp G, Laviolette M, Cohn L, McEvoy C, Bansal S, Shifren A, Khatri S, Grubb GM, McMullen E, Strauven R, Kline JN. Eur Respir J. 2017 Aug; 2017 Aug 31. PMID: 28860266.
A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression.Yan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL. BMC Bioinformatics. 2017 Jun 20; 2017 Jun 20. PMID: 28637421.
Sputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma.Nezgovorova V, Liu Q, Hu B, Villalobos JL, Yan X, Niu N, Holm C, Grant NP, Marone S, Ravage-Mass L, Lee CG, Elias JA, Cohn L, Chupp GL. Ann Am Thorac Soc. 2016 Mar. PMID: 27027964.
Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma.Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Ann Am Thorac Soc. 2016 Mar. PMID: 27027945.
Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N, Cohn L, Chupp GL. J Allergy Clin Immunol. 2015 Jul; 2015 Jan 13. PMID: 25592985.
Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma.Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL. Am J Respir Crit Care Med. 2015 May 15. PMID: 25763605.
Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. J Exp Med. 2010 Nov 22; 2010 Oct 25. PMID: 20975041.
Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA. J Exp Med. 2009 May 11; 2009 May 4. PMID: 19414556.
Asthma: mechanisms of disease persistence and progression.Cohn L, Elias JA, Chupp GL. Annu Rev Immunol. 2004. PMID: 15032597.