George R. Cowgill Professor of Medicine (Endocrinology) and Professor of Cellular And Molecular Physiology; Co-Director, Yale Diabetes Research Center, Internal Medicine
C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology)
Associate Professor of Medicine (Endocrinology) and of Cell Biology; Associate Section Chief, Section of Endocrinology and Metabolism; Member, Yale Center for Molecular and Systems Metabolism (YMSM)Dr. Jonathan Bogan is a physician-scientist whose research focuses on understanding mechanisms that regulate glucose uptake and metabolism in fat and muscle. He received a B.S. in electrical engineering from Yale College and an M.D. from Harvard Medical School and the Harvard-M.I.T. Division of Health Sciences and Technology. His thesis work in genetics was done with Dr. David Page at the Whitehead Institute/M.I.T., where he contributed to mapping the human Y chromosome. Dr. Bogan did his residency in Internal Medicine and fellowship in Endocrinology at Massachusetts General Hospital. During his fellowship and subsequently as a faculty member at Harvard, he worked with Dr. Harvey Lodish at the Whitehead Institute, and conceptualized and carried out a genetic screen to study insulin action. This work led to several subsequent studies to elucidate a new mechanism by which fat and muscle cells regulate metabolism. Dr. Bogan joined the Yale faculty in 2002 and he is currently a tenured Associate Professor of Medicine. Dr. Bogan also holds appointments in the Department of Cell Biology and in the Yale Center for Molecular and Systems Metabolism, and he directs the Cell Biology Core of the Yale Diabetes Research Center. Dr. Bogan has been the recipient of numerous awards, including a NIH Physician-Scientist Award, an American Diabetes Association Career Development Award, and a Smith Family Foundation Award for Excellence in Biomedical Research. He was named a W.M. Keck Foundation Distinguished Young Scholar in Medical Research. Dr. Bogan has been elected to the American Society for Clinical Investigation and Interurban Clinical Club. He has served widely on review panels for the NIH and American Diabetes Association. Dr. Bogan also serves as an Attending Physician at Yale-New Haven Hospital, as co-Director of the Energy and Metabolism Master Course in the M.D. curriculum, and as Assistant Director for Education in the Yale M.D.-Ph.D. Program.
Sterling Professor of Immunobiology; Investigator, Howard Hughes Medical InstituteDr. Flavell is Sterling Professor of Immunobiology at Yale University School of Medicine, and an Investigator of the Howard Hughes Medical Institute. He received his B.Sc. (Honors) in 1967 and Ph.D. in 1970 in biochemistry from the University of Hull, England, and performed postdoctoral work in Amsterdam (1970-72) with Piet Borst and in Zurich (1972-73) with Charles Weissmann. Before accepting his current position in 1988, Dr. Flavell was first Assistant Professor (equivalent) at the University of Amsterdam (1974-79); then Head of the Laboratory of Gene Structure and Expression at the National Institute for Medical Research, Mill Hill, London (1979-82); and subsequently President and Chief Scientific Officer of Biogen Research Corporation, Cambridge, Massachusetts (1982-88). Dr. Flavell is a fellow of the Royal Society, a member of the National Academy of Sciences as well as the National Academy of Medicine. Richard Flavell uses transgenic and gene-targeted mice to study Innate and Adaptive immunity, T cell tolerance and activation in immunity and autoimmunity,apoptosis, and regulation of T cell differentiation.
C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology)My background and research are in translational immunology. I am interested in understanding the basis for autoimmune diseases and developing new therapies based on our understanding of disease mechanisms. My focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work as well as clinical studies to understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies my lab has been very interested in analysis of beta cell function in Type 1 diabetes and identifying the cellular mechanisms that can protect them from immune killing. We have also been studying the development of autoimmune diabetes in patients with cancers who are treated with checkpoint inhibitors. Our clinical and basic studies are focused on understanding how beta cells are destroyed and react to inflammation. Finally, with the COVID-19 pandemic, we have been studying the immunologic basis for responses in children and adults who are hospitalized with COVID-19 to understand the mechanisms that can lead to disease protection.
Associate Professor of MedicineDr. Raimund Herzog is an Assistant Professor in Endocrinology at Yale School of Medicine. He received his M.D. from University of Ulm, Germany before moving to the US, where he pursued his training in Internal Medicine at Yale School of Medicine. He earned his M.H.S. in the YCCI Junior Faculty Scholars program while further specializing in Endocrinology at Yale. In addition to caring for patients at the Yale Diabetes Center and teaching medical students Dr. Herzog maintains an active translational research program. A physician scientist with a strong interest in neuroscience and diabetes, Dr. Herzog’s laboratory is focused on characterizing and preventing its central nervous complications. He uses state-of-the-art technologies like in vivo NMR spectroscopy and phospho-proteomics to define the impact of diabetes and intensive insulin treatment on brain metabolism and cognition. His work extends from cell culture and animal models all the way to translation of findings to human subjects. It has produced novel insights into the molecular mechanisms underlying brain energy substrate metabolism thereby laying the basis for the development of targeted therapies that will protect the brain from diabetes complications and injury. In a related area Dr. Herzog’s workgroup has engaged in several collaborative projects that apply his understanding of metabolism towards more comprehensive and unbiased metabolomic analysis of peripheral plasma metabolites in an obese and diabetic adolescent cohort. Furthermore he is exploring the role of circulating small molecules and lipids in the context of aging-related cognitive decline in a cohort of elderly subjects. As part of his studies he has established a close working relationship with the Magnetic Resonance Research Center, Keck Mass Spectrometry Center and the Biostatistics Resource at Yale. His studies are funded by several NIH and private foundation awards and have resulted in high impact publications in journals like The Journal of Clinical Investigation, Diabetes and Endocrinology.
Senior Research Scientist in Medicine (Endocrinology); Director, Diabetes Endocrinology Research Center Molecular Core
George R. Cowgill Professor of Medicine (Endocrinology) and Professor of Cellular And Molecular Physiology; Co-Director, Yale Diabetes Research Center, Internal MedicineDr. Shulman is the George R. Cowgill Professor of Medicine and Cellular & Molecular Physiology at Yale. He is also Co-Director of the Yale Diabetes Research Center. Dr. Shulman has pioneered the use of magnetic resonance spectroscopy combined with mass spectrometry to non-invasively examine intracellular glucose and fat metabolism in humans and transgenic rodent models that have led to several paradigm shifts in our understanding of type 2 diabetes (T2D), including the molecular mechanisms by which ectopic lipid promotes liver and muscle insulin resistance, as well as developing new drugs for the treatment of T2D, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Dr. Shulman is the recipient of the Stanley J. Korsymeyer Award from the American Society for Clinical Investigation, the Outstanding Clinical Investigator Award from the Endocrine Society, the Solomon Berson Award from the American Physiological Society and the Banting Medal for Lifetime Scientific Achievement from the American Diabetes Association. Dr. Shulman is a Fellow of the American Association for the Advancement of Science, Inaugural Fellow of the American Physiological Society and he has been elected to the American Society for Clinical Investigation, the Association of American Physicians, the National Academy of Medicine, the American Academy of Arts and Sciences and the National Academy of Sciences.
Professor of Pediatrics (Endocrinology)William V. Tamborlane, MD, received his undergraduate BS degree from Georgetown University and was also a graduate of Georgetown University School of Medicine, where he completed his residency in pediatrics before going to Yale as a postdoctoral fellow in pediatric endocrinology. His scientific accomplishments over the past 45 years have established his international reputation as one of the most highly regarded clinical scientists in childhood diabetes and related disorders. He has published more than 1,000 original articles, chapters and reviews in the area of diabetes. Major accomplishments have included pioneering studies in the development of insulin pump therapy, direction of the Yale Center in the NIDDK-sponsored DCCT/EDIC and GRADE studies, and investigations of diabetes-induced defects in counterregulatory hormone responses to hypoglycemia. The prime focus of his work has been in patient-oriented studies in type 1 and type 2 diabetes and related metabolic and endocrine disorders. The hallmark of his research has been to overcome metabolic, physiologic and psychological obstacles to successful management of diabetes. Current research effort is focused on applying recent advances in diabetes technology towards the development of an artificial pancreas for individuals with type 1 diabetes and the study of new treatments of childhood obesity and type 2 diabetes. He is the recipient of many awards and honors and is frequently listed in publications of distinction, including American Men and Women of Science, The Best Doctors in America, America’s Top Doctors and America’s Top Pediatricians. In 2006 and 2011, he was awarded the Mary Tyler Moore and S. Robert Levine Award for Excellence in Clinical Research in Type 1 Diabetes by the Juvenile Diabetes Research Foundation. he has also received the 2009 Diabetes Technology Society’s Diabetes Technology Leadership Award, the 2010 American Diabetes Association Outstanding Physician Clinician Award, the 2014 National Award for Career Achievement and Contributions to Clinical, the Translational Science by ACRT/SCTS/AFMR, the 2014 Diabetes Prize for Achievement by the International Society for Pediatric and Adolescent and the 2017 American Diabetes Association award for Outstanding Achievement in Clinical Diabetes Research. He has served on the FDA’s Endocrine Advisory Board, on the National Board of Directors of the American Diabetes Association, was the first Steering Committee Chair of the Diabetes Research in Children Network, is the Founder and Chair of the Pediatric Diabetes Consortium and former Vice Chair (for Pediatrics) of the T1D Exchange Clinic Registry. He leads a multidisciplinary team of physicians, diabetes nurse educators, dieticians and social workers that care for more than 1000 children, adolescents and young adults with diabetes. He has also been the mentor of many young physician scientists in their training and career development in clinical research in diabetes.
Professor of Medicine (Endocrinology); Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)
External Advisory Board
Professor of Medicine at Columbia University and Director of the Columbia University Diabetes and Endocrinology Research Center in New York City
Professor of Medicine at Columbia University and Director of the Columbia University Diabetes and Endocrinology Research Center in New York City
Joe C. Davis Chair in Biomedical Science, Medicine, and Molecular Physiology and Biophysics Professor, Vanderbilt Diabetes Center Director, Division of Diabetes and Endocrinology at Vanderbilt University
Joe C. Davis Chair in Biomedical Science, Medicine, and Molecular Physiology and Biophysics Professor, Vanderbilt Diabetes Center Director, Division of Diabetes and Endocrinology
Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases at the University of Pennsylvania
Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
Functions of the Administrative Core
- Administrative and Financial Management
- Provision of Research Support Services
- Administration of the Pilot and Feasibility Project Program
- Provision of a Scientific Enrichment Program
The DRC Administrator is directly responsible for maintaining fiscal records and coordinating the personnel involved in its Scientific Cores. The Administrative Core supervises all purchases related to the Center budget and maintains accurate monthly statements of these budgets for distribution to the Core Directors/Co-Directors and to the University's Grant and Contract Administration. Budgets are monitored to assure that there is no budgetary overlap between the DRC and the grants of individual users of Core resources. In addition, it monitors all fees for DRC Cores. The staff is responsible for the preparation of all required reports concerning the activities of the DRC, including competing and non-competing renewal applications.
Coordination and Review
A key function of the Core is to facilitate the Director's activities as overseer of the Scientific Cores, the Pilot and Feasibility (P&F) Program, and the overall progress of the Center. Data on the use and services of the Cores are evaluated regularly. The administrative core plans and coordinates regular administrative meetings of the Executive Committee, the P&F Oversight Committee, and prepares reports on the discussions and decisions of the Committee. The staff also is responsible for planning and organizing visits by members of the DRC's external Advisory Board.
The Core is responsible for organizing the review of Pilot/Feasibility Project applications and for budgetary oversight of the funded applications. They provide support to the grantees and collect data on the outcomes of the Pilot/Feasibility projects.
The Core is responsible for planning and organizing the various DRC Seminar Programs. The staff also prepares a calendar of conferences/lectures in diabetes-related areas that are conducted within the basic and clinical departments of the School of Medicine, including Endocrine “Grand Rounds”, Diabetes Journal Club, Immunobiology Seminar Series, the Cell Biology Conference, among others.There is close interaction with the Division of Endocrinology and other departments at the medical school when there are visitors with shared interests. The Core distributes notification of meetings to all Center members as well as appropriate pre- and postdoctoral trainees.
The Administrative staff is responsible for compiling and updating DRC technical resources, functions and cores activities for distribution to members on its website, including administrative services and services provided by the scientific cores. This allows for efficient access to the DRC and to avoid duplication of resources.
Support of Clinical Translation Core Research
Many of the DRC investigators conduct human research studies that utilizes facilities and resources that are designated for clinical research. The DRC Administrative Core provides support for the operations of these sites collaboratively with the Yale Center for Clinical Investigation (YCCI). The tasks involved are broad and are used for patient recruitment, administrative and regulatory tasks, specialized research services (e.g. imaging), procurement and storage of research samples, and data acquisition from the electronic health record (Epic). The administrative task can also assist DRC investigators in recruitment of underrepresented minorities and women for research studies. This helps to ensure that subjects participating in diabetes-related research projects supported by the DRC are representative of Connecticut's population of non-diabetics, Type 1 and Type 2 diabetic patients and patients with obesity. Our access to and recruitment of minorities is facilitated by the presence of the Yale Primary Care Center, which provides health care to a large segment of the minority community (both African-Americans and Hispanics) in the New Haven area as well as through outreach programs sponsored by the YCCI.
The Administrative Core provides statistical support to DRC investigations. James Dziura, PhD, offers consultative services to DRC members in study design and statistical analysis at no or at reduced cost (depending on requirements). Dr. Dziura is a Professor of Emergency Medicine. Deputy Director, Yale Center for Analytical Sciences and Deputy Director, Yale Data Coordinating Center.
Relationship of DRC to the Institution
The Dean of the School of Medicine, Dr. Nancy Brown, is the institutional official ultimately responsible for the conduct of the DRC. As such, she approves appointments to the External Advisory Committee, and receives reports of Center progress. The Directors of the DRC are responsible for facilitating communications between the Dean, the Executive Committee, the Grant and Contract Administration, the External Advisory Committee and NIDDK.
The Administrative Core carries out financial monitoring of the DRC, on a day-to-day, basis. Although the University has a centralized Grants and Contract Administration Office, the scope of the DRC grant requires continual monitoring of purchases and salary commitments on an ongoing basis within the Center administration for effective utilization of Center funds. The Directors and appropriate personnel receive accurate accounting of expenditures on a monthly basis. The DRC Administrative Core maintains a working relationship with the Grants and Contract Office of the School of Medicine to facilitate fiscal management.
The Administrative Core will monitors the budgets of the Cores and Pilot and Feasibility Projects. The funds for the latter are sent to the applicants primary department and managed there. Budget recommendations will be given to individual PIs concerning provisions for supplies and animals, not available from the Core budget, and where the Core provides personnel and supplies, guidance is given to assure that there is no duplication in individual extramural or intramural grants.
For more information about Yale DRC, please contact: