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Administrative Core

Co-Director, Gerald I. Shulman, MD, PhD
Co-Director, Kevan Herold, MD
Director of the Pilot and Feasibility Program, Kevan Herold, MD
Director of the Enrichment Program, Tamas Horvath, DVM, PhD

Executive Committee

Gerald Shulman, MD, PhD
Jonathan Bogan, MD
Richard Flavell, PhD
Kevan Herold, MD
Raimund Herzog, MD
William Philbrick, PhD
William Tamborlane, MD
Li Wen, MD, PhD

External Advisory Board

Domenico Accili, MD
Al Powers, PhD
Michael Czech, MD
Mitch Lazar, MD

Administrative Associate

Kathleen Marcucio (203-737-5071)

Functions of the Administrative Core

The Administrative Core is designed to provide centralized offices for the coordination of the DRC's research activities. The Core operates under the supervision of co-Directors Dr Gerald Shulman and Dr Kevan Herold, and is accessible to all of the members and personnel participating in the DRC. The principle functions of the Core are:

  • Administrative and Financial Management
  • Provision of Research Support Services
  • Administration of the Pilot and Feasibility Project Program
  • Provision of a Scientific Enrichment Program

Grant Management

The DRC Administrator is directly responsible for maintaining fiscal records and coordinating the personnel involved in its Scientific Cores. The Administrative Core supervises all purchases related to the Center budget and maintains accurate monthly statements of these budgets for distribution to the Core Directors/Co-Directors and to the University's Grant and Contract Administration. Budgets are monitored to assure that there is no budgetary overlap between the DRC and the grants of individual users of Core resources. In addition, it monitors all fees for DRC Cores. The staff is responsible for the preparation of all required reports concerning the activities of the DRC, including competing and non-competing renewal applications.


A key function of the Core is to facilitate the Director's activities as overseer of the Scientific Cores, the Pilot and Feasibility (P&F) Program, and the overall progress of the Center. The staff plans and coordinates regular administrative meetings of the Executive Committee, the P&F Oversight Committee, and prepares reports on the discussions and decisions of the Committee. The staff also is responsible for planning and organizing visits by members of the DRC's external Advisory Board, including travel and hotel arrangements.

Pilot/Feasibility Program

The Core is responsible for facilitating the review of Pilot/Feasibility Project applications and for budgetary oversight of the funded applications. They provide support to the grantees to facilitate the completion of annual progress reports. In addition, the staff is responsible for records concerning the outcome of funded grants and careers of funded investigators.

Enrichment Program

The Core is responsible for planning and organizing the various DRC Seminar Programs, including notification of these meetings to all Center members as well as appropriate pre- and postdoctoral trainees. The staff also schedules the agenda of meetings between DRC members and the visiting lecturers and coordinates travel plans and expense accounts of the speakers. The DRC Administrative staff also coordinates plans for the DRC Symposium and annual retreat.

Informational Services

The Administrative staff is responsible for compiling and updating DRC technical resources, functions and cores activities for distribution to members on its website, including administrative services and services provided by the scientific cores. This allows for efficient access to the DRC and to avoid duplication of resources. The staff also prepares a calendar of conferences/lectures in diabetes-related areas that are conducted within the basic and clinical departments of the School of Medicine, including Endocrine “Grand Rounds”, Diabetes Journal Club, Immunobiology Seminar Series, the Cell Biology Conference, among others.

Support of Clinical Translation Core Research

A major strength of our center is the ability to address clinically relevant questions in diabetes and metabolic disorders using state-of-the-art techniques in human subjects. These complex initiatives have been supported in the past by the General Clinical Research Center. However, the research sites in which DRC studies are conducted have expanded over time. Moreover, DRC members have expressed the need for a number of other clinical resources, including patient/subject recruitment for studies, maintaining databases, diabetes nurse coordinators, research assistants for clinical trials, and blood processing support. As a result, the Executive Committee elected to establish a new Core Resource, the Diabetes Translational Core , that will provide these services at reduced cost to the DRC by leveraging funds from the CTSA-supported Yale Center for Clinical Investigation (YCCI). The DRC Administrative Core will provide support for the operations of the DRC/YCCI joint venture, thereby allowing DRC investigators and Translational Core personnel to focus their energies on the direct implementation of research. The Administrative Core will also promote DRC clinical research by developing a centralized registry of research volunteers and assist YCCI in developing a sample and DNA repository. The registry will enhance the ability of DRC investigators to implement and complete patient-based studies in a more timely fashion. Identification of all subjects will be kept strictly confidential and all data collected will only be released upon written consent of subject. The registry will utilize the secure resources of the Informatics Core of YCCI for data storage and retrieval. The Administrative Core will also assist DRC members with database management and providing a link to the Informatics Core resource.

The DRC administrative staff will assist investigators to ensure that women and minorities participate in each of the research projects supported by the Clinical Translational Core and that subjects participating in diabetes-related research projects supported by the DRC are representative of Connecticut's population of non-diabetics, Type 1 and Type 2 diabetic patients and patients with obesity. Males and females will be equally represented in protocols and the issue of gender effects will be specifically examined with adjustments made in subject requirements based on these data. At no time will subjects be excluded on the basis of their race or gender. Our access to and recruitment of minorities is facilitated by the presence of the Yale Primary Care Center, which provides health care to a large segment of the minority community (both African-Americans and Hispanics) in the New Haven area.

Biostatistical Support

The Administrative Core will provide partial salary support for a biostatistician, James Dziura, PhD, to offer consultative services to DRC members in study design and statistical analysis at no or at reduced cost (depending on requirements). Dr. Dziura is a Professor of Emergency Medicine. Deputy Director, Yale Center for Analytical Sciences and Deputy Director, Yale Data Coordinating Center.

The Administrative Core provides the needed bridge between the investigator needing advice and Dr. Dziura.

Relationship of DRC to the Institution

The Dean of the School of Medicine, Dr. Robert Alpern, is the institutional official ultimately responsible for the conduct of the DRC. As such, he approves appointments to the External Advisory Committee, and receives reports of Center progress. The appointment of Dr. Alpern in 2004 has strengthened the commitment of the University to medical research, as evidenced by the decision to support the development of translational programs, and YCCI in particular. The Director of the DRC serves at the pleasure of the Dean and prepares a separate report for the External Advisory Committee, the Dean, and the NIDDK.

The Director of the DRC is responsible for facilitating communications between the Dean, the Executive Committee, the Grant and Contract Administration, the External Advisory Committee and NIDDK.

Financial Management

The Administrative Core carries out financial monitoring of the DRC, on a day-to-day, basis. Although the University has a centralized Grants and Contract Administration Office, the scope of the DRC grant requires continual monitoring of purchases and salary commitments on an ongoing basis within the Center administration for effective utilization of Center funds. It is essential that the Director and appropriate personnel receive accurate accounting of expenditures on a monthly basis, since there is no built-in mechanism to make up for cost overruns that might otherwise occur without a timely financial analysis of the DRC's fiscal activity. The DRC Administrative Core will, however, maintain a close working relationship with the Grants and Contract Office of the School of Medicine to facilitate fiscal management.

The Administrative Core will also be responsible for monitoring all budgets of the Cores and Pilot Projects to assess whether there is budgetary overlap with users of the facilities. Financial administrative assistance is provided by the Department of Medicine as well as by the Section of Immunobiology, the Department of Pediatrics, and the Department of Cell Biology. Budget recommendations will be given to individual PIs concerning provisions for supplies and animals, not available from the Core budget, and where the Core provides personnel and supplies, guidance is given to assure that there is no duplication in individual extramural or intramural grants.


For more information about the Yale DRC resources, please contact Dr. Gerald Shulman or Kathleen Marcucio.