Assistant Professor; Director, Kidney BioBank, Internal Medicine
Acute Interstitial Nephritis
Clinical diagnosis of acute interstitial nephritis (AIN) is challenging as there are no reliable, non-invasive biomarkers and its diagnosis currently requires a kidney biopsy. We are creating a cohort of participants with biopsy-confirmed AIN and controls and testing biomarkers of AIN. This work has identified CXCL9, tumor necrosis factor-α, and inteleukin-9 as biomarkers of AIN.
Contact Information
For more information, or if you are interested in collaborating on this study, please contact Dr. Dennis Moledina
Project Funding
Funding for this project comes, in part, from the following grants:
K23 DK117065 (NIH/NIDDK
Career Development Award
R01 DK128087 (NIH/NIDDK)
Biomarkers for Acute Interstitial Nephritis in Humans
Leadership
Associate Professor of Medicine (Nephrology) and Public Health (Chronic Disease Epidemiology); Director, Clinical and Translational Research Accelerator (CTRA); Course Director, Interpretation of the Medical Literature; Co Director, Human Genetics and Clinical Research Core
Collaborators
Michael Kashgarian
Professor of Pathology, Yale University
Michael Kuperman, MD
Nephropathologist, Arkana Laboratories
Randy Luciano, MD
Associate Professor of Medicine, Nephrology, Yale University
Gilbert Moeckel, MD, PhD
Professor of Pathology, Yale University
Chirag R. Parikh, MD, PhD
Adjunct Professor of Medicine, Nephrology, Yale University
Mark A. Perazella, MD
Professor of Medicine, Nephrology, Yale University
Publications
- Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis.Moledina DG, Obeid W, Smith RN, Rosales I, Sise ME, Moeckel G, Kashgarian M, Kuperman M, Campbell KN, Lefferts S, Meliambro K, Bitzer M, Perazella MA, Luciano RL, Pober JS, Cantley LG, Colvin RB, Wilson FP, Parikh CR. J Clin Invest. 2023 Jul 3; 2023 Jul 3. PMID: 37395276.
- Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data.Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Nephrol Dial Transplant. 2022 Oct 19. PMID: 34865148.
- Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis.Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Nephrol Dial Transplant. 2021 Sep 27. PMID: 33125471.
- Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis.Moledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. JCI Insight. 2019 May 16; 2019 May 16. PMID: 31092735.
- Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians.Moledina DG, Parikh CR. Nephron. 2019; 2019 Jun 14. PMID: 31203275.
- Drug-Induced Acute Interstitial Nephritis.Moledina DG, Perazella MA. Clin J Am Soc Nephrol. 2017 Dec 7; 2017 Sep 11. PMID: 28893923.
- Proton Pump Inhibitors and CKD.Moledina DG, Perazella MA. J Am Soc Nephrol. 2016 Oct; 2016 Apr 14. PMID: 27080978.
- PPIs and kidney disease: from AIN to CKD.Moledina DG, Perazella MA. J Nephrol. 2016 Oct; 2016 Apr 12. PMID: 27072818.