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Yale Center for Asthma and Airway Disease (YCAAD)
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INFORMATION FOR

Research

The Yale Center for Asthma and Airways Diseases (YCAAD) is a highly regarded academic clinical center recognized for its excellence in education, research, and patient care. The center consists of three programs: the Asthma Program, the Bronchiectasis and Nontuberculous Mycobacteria (NTM) Infections Program, and the Chronic Obstructive Pulmonary Disease (COPD) Program.

Established in 2000, YCAAD provides opportunities for patients with complicated airway diseases to participate in innovative research through industry-sponsored clinical trials and NIH-funded translational research. In addition to advancing cutting-edge research to improve patients’ lives, YCAAD is committed to training the next generation of leaders in the field. The center provides education opportunities for students, residents, fellows, and health care providers around the region on the cutting-edge management of airway diseases.

Publications

2026

  • Integrated molecular networks reveal latent components distinguishing type 2-high and type 2-low asthma

    Ramirez M, Diaz M, Wang N, Liu Q, Li H, Kay S, Shuguli M, Zielonka J, Wilson G, Sauler M, Wang Z, Yan X, Chupp G, Gomez J. Integrated molecular networks reveal latent components distinguishing type 2-high and type 2-low asthma. BMJ Open Respiratory Research 2026, 13: e004003. PMID: 42150795, PMCID: PMC13185048, DOI: 10.1136/bmjresp-2025-004003.
    Peer-Reviewed Original Research

  • Civilian Occupational Exposure to Vapors, Gas, Dust, or Fumes and Respiratory Health Among United States Military Veterans

    Mohazzab‐Hosseinian S, Redlich C, Korpak A, Timmons A, Smith N, Nakayama K, Kheradmand F, Fan V, Jerrett M, Montgrain P, Wendt C, Kuschner W, Wan E, Garshick E, Blanc P. Civilian Occupational Exposure to Vapors, Gas, Dust, or Fumes and Respiratory Health Among United States Military Veterans. American Journal Of Industrial Medicine 2026, 69: 503-511. PMID: 42028841, PMCID: PMC13241858, DOI: 10.1002/ajim.70083.
    Peer-Reviewed Original Research

  • Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis

    Zielonka J, Li N, Liu Y, Yan X, Wang Z, Ramirez M, Figueroa A, Korde A, Yin H, Britto C, Singh I, Sun H, Herzog E, Feghali‐Bostwick C, Hinchcliff M, Ryu C, Gomez J. Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis. Arthritis & Rheumatology 2026 PMID: 41930625, DOI: 10.1002/art.70163.
    Peer-Reviewed Original Research

  • PrecISE—a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort

    Denlinger L, Israel E, Moore W, Georas S, Wright R, Castro M, Peden D, Anstrom K, Bleecker E, Alexander L, Cahill K, Cardet J, Carr T, Cedano J, Chen A, Chupp G, Comhair S, DiMango E, Erzurum S, Fahy J, Fajt M, Gaston B, Jackson D, Jain S, Jarjour N, Kenyon N, Kraft M, Krishnan J, Kumar R, Lugogo N, Martinez F, Marquis M, Pappalardo A, Phipatanakul W, Rank M, Rosenberg S, Salciccioli J, Sanchez M, Smith L, Sumino K, Szefler S, Tang M, Vijayanand P, Wechsler M, Wenzel S, White S, Zeki A, Ivanova A, Bacharier L, Akuthota P, Team N, Bleecker E, Carr T, Moore W, Rank M, Camacho G, Gerald L, Hastie A, Krings J, Martinez F, Merchen J, Meyers D, Nirendran N, Ortega V, Pippins A, Rusk A, Schunk R, Skeps R, Simmons T, Williamson P, Zein J, Israel E, Cardet J, DiMango E, Phipatanakul W, Bailey J, Banzon T, Bartnikas L, Baxi S, Betapudi V, Brick I, Casale T, Cinelli M, Crestani E, Cunningham A, Esty B, Fandozzi E, Fernandez J, Fitzpatrick E, Flam B, Forth V, Gaffin J, Gentile K, Gueye-Ndiaye S, Haley K, Heromin R, Hauptmann M, Kaage T, Kelly M, Kraemer M, LaBere B, Lai P, Le M, Ledford D, Lee J, Lee J, Lockey R, Macginnitie A, McCarty K, Moss K, Mukharesh L, O'Neil A, Pistenmaa C, Pepper A, Pimental M, Queheillalt D, Robinson A, Salciccioli J, Saroya T, Smith C, Trevedi M, Trippa L, Tulchinsky A, Vitiello A, Yee C, Zakar K, White S, Kumar R, Moy J, Rosenberg S, Aalemansour H, Buechler K, Carter T, Fu J, Hixon J, Jackson C, Ji Y, Johnson C, Kalhan R, Kane J, Kaur O, Li G, Lippner E, Makhija M, Maleckar S, Naureckas E, Nyenhuis S, Peters A, Press V, Qureshi M, Ryba D, Sheng J, Smith L, Xu B, Wechsler M, Szefler S, Chupp G, Holguin F, Kraft M, Liu A, Rogers L, Anderson D, Belimezova S, Bitzan J, Bose S, Brock J, Sanchez J, Clark B, Cohn L, Cotarian A, Eisenberg E, Estrom J, Glassmeyer I, Villalobos J, Grant N, Gruberg B, Guntur V, Hay O, Hills A, Hsieh J, Kessler J, Kolakowski C, Miyazawa N, Pak J, Pruitt D, Rhoads S, Sharma S, Stevens A, Tippin B, Valente K, Vicencio A, Wainscoat C, Weber J, Wessels G, White M, Winnica D, Zeitlin P, Denlinger L, Jarjour N, Krishnan J, Agnihotri N, Bach J, Bires N, DeLisa J, Fichtinger P, Floerke H, Fritz B, Grogan J, Guadarrama A, Hasse W, Jackson D, Kaspari R, Kelley R, Klaus D, Lowell P, Larson L, Norwick L, O’Brien M, Palas T, Pappalardo A, Read E, Schraml A, Schiebler M, Sorkness R, Tattersall M, Wollet L, Gaston B, Erzurum S, Teague W, Chmiel J, Ross K, Aronica M, Beck B, Bendy L, Borish L, Chedraoui C, Comhair S, Davis M, Dix A, Fakhry B, Gammell R, Gluvna A, Hamm E, Heskett M, Hu B, Khatri S, Kirwan J, Kloepfer K, Koo M, Labadia M, Marko A, Matheis N, Mey J, Mulya A, Murphy D, Owensby R, Parker L, Pennington E, Roesch E, Sharp J, Smith K, Solanki N, Veri L, Shifflett K, Yang F, Wenzel S, Lugogo N, Bagheri A, Cislo L, Fajt M, Gauthier M, Hadden M, James P, Mohan A, Moore J, Nouraie S, Ramonell R, Romanek R, Sullivan L, Trudeau J, Zhang M, Akuthota P, Jain S, Vijayanand P, Barry J, Beg N, Brickner H, Alexander L, Diaz D, Jafari Y, McKeon N, Fahy J, Kenyon N, Almario R, Charbit A, Cho L, Gale B, Haczku A, Harper R, Houston T, Kain C, Kivler C, Kuhn B, Liu D, McCourt P, Miller J, Nguyen A, Orain X, Peters M, Plough A, Ramirez K, Rossi L, Schivo M, Singapuri A, Teuber S, Tham T, Tompkins D, Vi J, Zeki A, Castro M, Bacharier L, Sumino K, Atha J, Boomer J, Cahill K, Clover A, Dorman V, Hoffman E, Jackson F, Klinck M, Krings J, Madison J, Quigley J, Quinones T, Saxena S, Sharpe M, Troyer J, Yen-Declue H, Zulich A, Ivanova A, Anstrom K, LaVange L, Bagaason S, Britt A, Bryan H, Burbank A, Chen A, Culpepper C, DeMarcus F, Fenu C, Gotman N, Green R, Harrison L, James J, Kosorok J, Kosorok M, Littleton L, Marquis M, O'Neal W, Peden D, Price R, Quibrera P, Ritz C, Sanchez M, Schwartz S, Slye N, Song T, Wilson N, Croxton T, Lu J, Noel P, Bamdad J, Georas S, Wright R. PrecISE—a biomarker-stratified adaptive trial of 5 interventions in severe asthma: Final protocol and the baseline cohort. The Journal Of Allergy And Clinical Immunology 2026, 157: 1261-1273. PMID: 41707916, DOI: 10.1016/j.jaci.2026.02.001.
    Peer-Reviewed Original Research

  • Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: a multicenter, randomized, double-blind, phase 3A clinical trial (NIMBLE)

    Chupp G, Nagase H, Skowasch D, Devouassoux G, Côté A, Jackson D, Jackson D, Wechsler M, Imber V, McGinniss J, Sherine O, Howarth P, Pavord I, Chupp G, Nagase H, Skowasch D, Devouassoux G, Côté A, Jackson D, Jackson D, Wechsler M, Imber V, McGinniss J, Sherine O, Howarth P, Pavord I. Switching to twice-yearly depemokimab from mepolizumab/benralizumab in severe asthma: a multicenter, randomized, double-blind, phase 3A clinical trial (NIMBLE). American Journal Of Respiratory And Critical Care Medicine 2026, 212: 921-935. PMID: 41738176, PMCID: PMC13160935, DOI: 10.1093/ajrccm/aamag031.
    Peer-Reviewed Original Research
    This study investigates switching from frequent biologics to twice-yearly depemokimab for severe asthma, showing similar safety and control but slightly higher exacerbation rates.
    Full Summary

  • Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease

    Zhang Y, Wei H, Nouws J, Jiang W, Brewster R, Nguyen J, Liang S, Pass S, Wang W, Collin F, Oill A, Kim S, Siller S, Liu J, Zhao A, Hansbro P, Dela Cruz C, Britto C, Gomez J, Cloonan S, Herzog E, Lam T, Banovich N, Raredon M, Zhang X, Mangiola S, Homer R, Kaminski N, McDonough J, Polverino F, Yan X, Sauler M. Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease. Nature Genetics 2026, 58: 376-391. PMID: 41578022, PMCID: PMC12900648, DOI: 10.1038/s41588-025-02480-z.
    Peer-Reviewed Original Research

2025

2024

See All Publications