Research

The Yale Center for Asthma and Airways Diseases (YCAAD) is a highly regarded academic clinical center recognized for its excellence in education, research, and patient care. The center consists of three programs: the Asthma Program, the Bronchiectasis and Nontuberculous Mycobacteria (NTM) Infections Program, and the Chronic Obstructive Pulmonary Disease (COPD) Program.

Established in 2000, YCAAD provides opportunities for patients with complicated airway diseases to participate in innovative research through industry-sponsored clinical trials and NIH-funded translational research. In addition to advancing cutting-edge research to improve patients’ lives, YCAAD is committed to training the next generation of leaders in the field. The center provides education opportunities for students, residents, fellows, and health care providers around the region on the cutting-edge management of airway diseases.

Publications

2025

Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma.
Kay S, Rajeevan H, Son M, Kwah J, Ramirez M, Liu Y, Wang Z, Yan X, Nino G, Britto C, Chupp G, Gomez J. Sex-biased Gene Expression Underlies Immune Dysfunction in Asthma. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 884-896. PMID: 40587876, DOI: 10.1165/rcmb.2024-0565oc.
Peer-Reviewed Original Research
Concepts
Down Syndrome Alters Type III IFN and Proinflammatory Airway Epithelial Responses to Respiratory Syncytial Virus Infection.
Chorvinsky E, Bhattacharya S, Bera B, Welham A, Ismat K, Lawlor C, Preciado D, Gomez J, Morizono H, Pillai D, Gutierrez M, Jaiswal J, Nino G. Down Syndrome Alters Type III IFN and Proinflammatory Airway Epithelial Responses to Respiratory Syncytial Virus Infection. American Journal Of Respiratory Cell And Molecular Biology 2025, 73: 951-964. PMID: 40587878, PMCID: PMC12699336, DOI: 10.1165/rcmb.2025-0068oc.
Peer-Reviewed Original Research
Concepts
Work Practices and Respirable Crystalline Silica Exposures in Stone Countertop Fabrication Shops
McGowan C, Cantley L, Klein R, Redlich C. Work Practices and Respirable Crystalline Silica Exposures in Stone Countertop Fabrication Shops. American Journal Of Industrial Medicine 2025, 68: 973-987. PMID: 40946211, DOI: 10.1002/ajim.70020.
Peer-Reviewed Original Research
Concepts
Pediatric Airway Biology and Transcriptomic Assessment of Therapies
Nino G, Gomez J, Gutierrez M. Pediatric Airway Biology and Transcriptomic Assessment of Therapies. JAMA Pediatrics 2025, 179: 947-949. PMID: 40658411, DOI: 10.1001/jamapediatrics.2025.2070.
Peer-Reviewed Original Research
Mepolizumab in patients with severe asthma and blood eosinophil counts between 150 and 300 cells per µL: benefits at two years
Canonica G, Bagnasco D, Lee J, Chupp G, Schleich F, Oppenheimer J, Zhang L, Alfonso-Cristancho R, Howarth P. Mepolizumab in patients with severe asthma and blood eosinophil counts between 150 and 300 cells per µL: benefits at two years. ERJ Open Research 2025, 11: 01390-2024. PMID: 41220814, PMCID: PMC12598589, DOI: 10.1183/23120541.01390-2024.
Peer-Reviewed Original Research
Concepts
Impact of Demographics on Mepolizumab Effectiveness in Severe Asthma: One-Year REALITI-A Subanalysis
Chupp G, Heaney L, Pelaia G, Almonacid C, Maxwell A, Zhang L, Alfonso-Cristancho R, Howarth P, Brusselle G. Impact of Demographics on Mepolizumab Effectiveness in Severe Asthma: One-Year REALITI-A Subanalysis. The Journal Of Allergy And Clinical Immunology In Practice 2025, 13: 3286-3295. PMID: 40780384, DOI: 10.1016/j.jaip.2025.07.049.
Peer-Reviewed Original Research
Concepts
Military Inhalational Exposures Outside the Theater of Conflict and Chronic Respiratory Symptoms
Hosseini R, Garshick E, Slade M, Timmons A, Korpak A, Smith N, Nakayama K, Baird C, Ciminera P, Kheradmand F, Fan V, Hart J, Koutrakis P, Kuschner W, Ioachimescu O, Jerrett M, Montgrain P, Proctor S, Wendt C, Wongtrakool C, Wan E, Blanc P, Redlich C. Military Inhalational Exposures Outside the Theater of Conflict and Chronic Respiratory Symptoms. JAMA Network Open 2025, 8: e2522080. PMID: 40690216, PMCID: PMC12281241, DOI: 10.1001/jamanetworkopen.2025.22080.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation
Yu S, Hu B, Sun Y, Peng X, Lee C, Woo S, McGovern J, Zielonka J, Saber T, Ghincea A, Gandhi S, Walia A, Pivarnik T, Ishikawa G, Shao S, Sun H, Gunes B, Kujawski S, Perez S, Odell W, Hinchcliff M, Varga J, Feghali-Bostwick C, Sauler M, Gomez J, Ryu C, Herzog E. Cyclic GMP-AMP synthase expression is enhanced in systemic sclerosis-associated interstitial lung disease and stimulates inflammatory myofibroblast activation. European Respiratory Journal 2025, 66: 2401564. PMID: 40374521, PMCID: PMC12332468, DOI: 10.1183/13993003.01564-2024.
Peer-Reviewed Original Research
Concepts
Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis
Adams T, Redlich C, Glazer C, Gulati M. Hypersensitivity pneumonitis associated with home mold exposure: A retrospective cohort analysis. PLOS ONE 2025, 20: e0323093. PMID: 40338891, PMCID: PMC12061107, DOI: 10.1371/journal.pone.0323093.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
The Potential Role of GPR87 in the Development of Pulmonary Fibrosis
Khoury J, Ahangari F, Justet A, Adams T, Manning E, Mcdonough J, Anderson S, Nekola F, Beermann M, Bauer Y, Gomez J, Kaminski N. The Potential Role of GPR87 in the Development of Pulmonary Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7110-a7110. DOI: 10.1164/ajrccm.2025.211.abstracts.a7110.
Peer-Reviewed Original Research
Sex-Specific Immune Transcriptional Programming by Pseudomonas in Cystic Fibrosis
Knight C, Yin H, Kockar Kizilirmak T, Adams T, Sauler M, Gomez J, Britto-Leon C. Sex-Specific Immune Transcriptional Programming by Pseudomonas in Cystic Fibrosis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a1109-a1109. DOI: 10.1164/ajrccm.2025.211.abstracts.a1109.
Peer-Reviewed Original Research
High Exacerbators in Cystic Fibrosis Have Sex-Specific Neutrophil Transcriptomes
Knight C, Yin H, Kockar Kizilirmak T, Adams T, Sauler M, Gomez J, Britto-Leon C. High Exacerbators in Cystic Fibrosis Have Sex-Specific Neutrophil Transcriptomes. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5557-a5557. DOI: 10.1164/ajrccm.2025.211.abstracts.a5557.
Peer-Reviewed Original Research
Higher Acute Exposure to Air Pollution Is Associated With Respiratory Hospitalizations in Idiopathic Pulmonary Fibrosis: Data From the IPF-PRO Registry
Sack C, Wojdyla D, Macmurdo M, Gassett A, Redlich C, Raghu G, Kaufman J, Olson A, Neely M, Snyder L, Gulati M, on behalf of the IPF-PRO Registry investigators. Higher Acute Exposure to Air Pollution Is Associated With Respiratory Hospitalizations in Idiopathic Pulmonary Fibrosis: Data From the IPF-PRO Registry. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3245-a3245. DOI: 10.1164/ajrccm.2025.211.abstracts.a3245.
Peer-Reviewed Original Research
Concepts
Civilian Occupational Exposures and Current Respiratory Symptoms in Veterans Previously Deployed to Southwest Asia and Afghanistan
Mohazzab-Hosseinian S, Redlich C, Timmons A, Korpak A, Smith N, Nakayama K, Baird C, Ciminera P, Kheradmand F, Fan V, Hart J, Koutrakis P, Kuschner W, Ioachimescu O, Jerrett M, Montgrain P, Proctor S, Wendt C, Wongtrakool C, Wan E, Garshick E, Blanc P. Civilian Occupational Exposures and Current Respiratory Symptoms in Veterans Previously Deployed to Southwest Asia and Afghanistan. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4259-a4259. DOI: 10.1164/ajrccm.2025.211.abstracts.a4259.
Peer-Reviewed Original Research
Concepts
Blast Exposure and Associations With Respiratory Symptoms Among Deployed Military Veterans to Southwest Asia and Afghanistan
Henkle B, Gravely A, Redlich C, Timmons A, Korpak A, Smith N, Nakayama K, Baird C, Ciminera P, Kheradmand F, Fan V, Hart J, Koutrakis P, Kuschner W, Ioachimescu O, Jerrett M, Montgrain P, Proctor S, Wongtrakool C, Wan E, Garshick E, Blanc P, Wendt C. Blast Exposure and Associations With Respiratory Symptoms Among Deployed Military Veterans to Southwest Asia and Afghanistan. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4261-a4261. DOI: 10.1164/ajrccm.2025.211.abstracts.a4261.
Peer-Reviewed Original Research
Concepts
The Role of Non-coding RNAs in Asthma T2-high and T2-low Endotypes
Zielonka J, Kay S, Chupp G, Gomez J. The Role of Non-coding RNAs in Asthma T2-high and T2-low Endotypes. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3430-a3430. DOI: 10.1164/ajrccm.2025.211.abstracts.a3430.
Peer-Reviewed Original Research
Asthma Exacerbations: Integrative Analysis of Mirna Activity in Using Single-cell Transcriptomics
Hadikhani P, Yan X, Chupp G, Liu Q, Ban G, Piparia S, Mcgeachie M, Sharma R, Weiss S, Kho A, Tantisira K. Asthma Exacerbations: Integrative Analysis of Mirna Activity in Using Single-cell Transcriptomics. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7773-a7773. DOI: 10.1164/ajrccm.2025.211.abstracts.a7773.
Peer-Reviewed Original Research
Twice-yearly Depemokimab Reduces Exacerbations and Improves Quality of Life in Patients With Uncontrolled Asthma Symptoms at Baseline: Subgroup Analyses of the Phase III SWIFT-1/2 Studies
Pavord I, Chupp G, Jackson D, Muccino D, Forth R, Kwiatek J, Vichiendilokkul A, Jackson D. Twice-yearly Depemokimab Reduces Exacerbations and Improves Quality of Life in Patients With Uncontrolled Asthma Symptoms at Baseline: Subgroup Analyses of the Phase III SWIFT-1/2 Studies. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5234-a5234. DOI: 10.1164/ajrccm.2025.211.abstracts.a5234.
Peer-Reviewed Original Research
Concepts
MicroRNA-223 Targets the FOXO1 Transcription Factor and Inflammatory Genes Involved in Asthma in Bronchial Epithelial Cells
Korde A, Ramirez M, Dubovik V, Zheng S, Yan X, Gomez J. MicroRNA-223 Targets the FOXO1 Transcription Factor and Inflammatory Genes Involved in Asthma in Bronchial Epithelial Cells. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2482-a2482. DOI: 10.1164/ajrccm.2025.211.abstracts.a2482.
Peer-Reviewed Original Research
Concepts
Characterization of Gene Networks Associated With ALOX15 Expression in Type 2-High Asthma
Shuguli M, Dubovik V, Ramirez M, Korde A, Gomez J. Characterization of Gene Networks Associated With ALOX15 Expression in Type 2-High Asthma. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a3492-a3492. DOI: 10.1164/ajrccm.2025.211.abstracts.a3492.
Peer-Reviewed Original Research
Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease.
Johannson K, Adegunsoye A, Behr J, Cottin V, Glanville A, Glassberg M, Goobie G, Jenkins R, Kim J, Lee C, Redlich C, Richeldi L, Salisbury M, Tetley T, Corte T. Impact of Environmental Exposures on the Development and Progression of Fibrotic Interstitial Lung Disease. American Journal Of Respiratory And Critical Care Medicine 2025, 211: 560-568. PMID: 39745380, DOI: 10.1164/rccm.202409-1730pp.
Peer-Reviewed Original Research
Concepts
Impact of atopic status, prior omalizumab use and baseline blood eosinophil count alone and in combination with total serum IgE on maintenance OCS reduction outcomes in patients with severe asthma treated with mepolizumab in the REALITI-A study
Liu M, Chaudhuri R, Chupp G, Heaney L, Lee J, Pilette C, Brusselle G, Alfonso-Cristancho R, Zhang L, Howarth P, Kumar A. Impact of atopic status, prior omalizumab use and baseline blood eosinophil count alone and in combination with total serum IgE on maintenance OCS reduction outcomes in patients with severe asthma treated with mepolizumab in the REALITI-A study. Revue Française D'Allergologie Et D'Immunologie Clinique 2025, 65: 104319. DOI: 10.1016/j.reval.2025.104319.
Peer-Reviewed Original Research
Concepts
Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma
Caruso C, Canonica G, Patel M, Smith A, Liu M, Alfonso-Cristancho R, Price R, Jakes R, Demetriou L, Valero A, Köhler T, Pilette C, Chupp G, Brusselle G, Howarth P. Prospective REALITI-A Study 2-Year Real-World Benefits of Mepolizumab in Severe Asthma. CHEST Pulmonary 2025, 3: 100107. DOI: 10.1016/j.chpulm.2024.100107.
Peer-Reviewed Original Research
Concepts
Long-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry.
Sack C, Wojdyla D, MacMurdo M, Gassett A, Kaufman J, Raghu G, Redlich C, Li P, Olson A, Leonard T, Todd J, Neely M, Snyder L, Gulati M, Baker A, Beegle S, Belperio J, Condos R, Cordova F, Southern B, Dilling D, Fitzgerald J, Flaherty K, Gibson K, Gulati M, Guntupalli K, Gupta N, Case A, Hotchkin D, Huie T, Kaner R, Kim H, Lancaster L, Lasky J, Lee D, Liesching T, Lipchik R, Lobo J, Luckhardt T, Mageto Y, Kokoszynska M, Morrison L, Namen A, Oldham J, Paul T, Zhang D, Porteous M, Raj R, Ramaswamy M, Russell T, Sachs P, Safdar Z, Shafazand S, Siddiqi A, Fowler R, Strek M, Rivas-Perez H, Tabak J, Walia R, Whelan T. Long-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry. Annals Of The American Thoracic Society 2025, 22: 378-386. PMID: 39531618, DOI: 10.1513/annalsats.202404-382oc.
Peer-Reviewed Original Research
Concepts
Silicosis: A Chronic Work-related Lung Disease
Fazio J, Heinzerling A, Gandhi S, Redlich C, Cummings K. Silicosis: A Chronic Work-related Lung Disease. ATS Scholar 2025, 6: 113-116. PMID: 39964259, PMCID: PMC11984649, DOI: 10.34197/ats-scholar.2024-0118pe.
Peer-Reviewed Original Research

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