2022
BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact
De Sadeleer LJ, Verleden SE, Schupp JC, McDonough JE, Goos T, Yserbyt J, Bargagli E, Rottoli P, Kaminski N, Prasse A, Wuyts WA. BAL Transcriptomes Characterize Idiopathic Pulmonary Fibrosis Endotypes With Prognostic Impact. CHEST Journal 2022, 161: 1576-1588. PMID: 35063449, PMCID: PMC9424328, DOI: 10.1016/j.chest.2021.12.668.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisIPF samplesIndependent validation cohortAvailable gene expression datasetsClinical characteristicsPrognostic impactWorse survivalPathophysiologic mechanismsPulmonary fibrosisClinical evolutionClinical variablesValidation cohortEnrichment analysisBAL samplesSurvival-associated genesBlood samplesEndotypesStudy designControl participantsMitochondrial dysfunctionPatientsFibrosisSurvivalTranscription factorsNumeric trends
2020
Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine
Gomez J, Kaminski N, Himes B. Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine. Respiratory Medicine 2020, 417-428. DOI: 10.1007/978-3-030-31507-8_28.Peer-Reviewed Original ResearchCritical careSleep medicinePrecision medicine strategiesNovel biomarker candidatesDisease endotypesClinical studiesDisease pathogenesisHealthcare providersNovel interventionsBiomarker candidatesMedicine strategiesPrecision medicineDrug targetsCareMolecular underpinningsWidespread implementationMedicineEndotypesPulmonaryPathogenesisCohortInitial discoveryBiomarkers