2020
Macrophage Migration Inhibitory Factor is not Associated with Sarcoidosis Susceptibility or Severity in Whites or Blacks
Odio CD, Miller EJ, Sauler M, Leng L, Piecychna M, Drake WP, Bucala R. Macrophage Migration Inhibitory Factor is not Associated with Sarcoidosis Susceptibility or Severity in Whites or Blacks. Sarcoidosis, Vasculitis, And Diffuse Lung Diseases 2020, 37: e2020003. PMID: 33264374, PMCID: PMC7690059, DOI: 10.36141/svdld.v37i3.9273.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorHealthy controlsMacrophage migration inhibitory factor (MIF) promoter polymorphismsSarcoidosis severityInhibitory factorAlpha-1 antitrypsin deficiencyLarge North American cohortHigh expressionSarcoidosis susceptibilityNorth American cohortPulmonary sarcoidosisSarcoidosis patientsAutoimmune diseasesInflammatory cytokinesSarcoidosis phenotypesSarcoidosis StudyAntitrypsin deficiencyPromoter polymorphismAmerican cohortSarcoidosisSmall sample sizeSeverityC SNPPatients
2017
Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension
Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee PJ, Fares WH. Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension. Pulmonary Circulation 2017, 7: 730-733. PMID: 28714356, PMCID: PMC5841895, DOI: 10.1177/2045893217724141.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorPulmonary arterial hypertension patientsPulmonary arterial hypertensionArterial hypertension patientsArterial hypertensionHypertension patientsAngiogenic biomarkersAngiogenic factorsSignificant positive correlationBiomarkersPositive correlationRegulation roleHypertensionPatientsFactorsPathobiology
2016
The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn
Kim BS, Stoppe C, Grieb G, Leng L, Sauler M, Assis D, Simons D, Boecker AH, Schulte W, Piecychna M, Hager S, Bernhagen J, Pallua N, Bucala R. The clinical significance of the MIF homolog d-dopachrome tautomerase (MIF-2) and its circulating receptor (sCD74) in burn. Burns 2016, 42: 1265-1276. PMID: 27209369, PMCID: PMC5010466, DOI: 10.1016/j.burns.2016.02.005.Peer-Reviewed Original ResearchConceptsTotal body surface areaMacrophage migration inhibitory factorSerum levelsClinical significanceCytokine macrophage migration inhibitory factorEarly post-burn periodPrediction of sepsisBody surface areaMigration inhibitory factorPost-burn periodBurn severity indexDopachrome tautomeraseClinical outcomesBurn patientsReceptor CD74Healthy controlsBurn injuryEarly predictorMember DPatientsPotential biomarkersCD74Inhibitory factorSoluble CD74Severity Index
2014
Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma
Gutiérrez A, Sauler M, Mitchell JM, Siegel MD, Trow TK, Bacchetta M, Fares WH. Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma. Heart & Lung 2014, 43: 574-576. PMID: 24928184, DOI: 10.1016/j.hrtlng.2014.05.006.Peer-Reviewed Case Reports and Technical NotesConceptsPulmonary artery sarcomaPulmonary embolismPresumed pulmonary embolismUnresolved pulmonary embolismCT pulmonary angiogramAnticoagulation treatmentProgressive symptomsPulmonary angiogramSurgical resectionPulmonary arteryPoor prognosisRare tumorAdditional imagingDifferential diagnosisProper diagnosisEmbolismSarcomaDiagnosisResectionPatientsDyspneaArteryPrognosisAngiogramsMetastasis
2013
Standard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension
Sauler M, Fares WH, Trow TK. Standard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension. Clinics In Chest Medicine 2013, 34: 799-810. PMID: 24267305, DOI: 10.1016/j.ccm.2013.08.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-dose calcium channel blockersCommon cardiopulmonary diseasesPAH-specific therapyPulmonary arterial hypertensionTreatment of patientsCalcium channel blockersPAH therapyArterial hypertensionAdjunct therapyOxygen therapyMedical therapyNonspecific therapyCardiopulmonary diseasePathologic understandingChannel blockersSmall studyTherapyHypertension researchExpert opinionAnticoagulationHypertensionDiureticsPatientsBlockersDigoxin
2011
Pulmonary Embolism in Older Patients
Mathur A, Sauler M, Pisani M. Pulmonary Embolism in Older Patients. Respiratory Medicine 2011, 133-153. DOI: 10.1007/978-1-60761-727-3_7.ChaptersVenous thromboembolic diseaseDeep vein thrombosisPulmonary embolismThromboembolic diseaseComplications of treatmentMiddle-aged subjectsHospital deathOlder patientsVein thrombosisSignificant morbidityGeriatric populationRisk factorsMedical conditionsEmbolismPatientsDiseaseDiagnosisDeathAgeTreatmentMorbidityThrombosisComplicationsPathophysiologyMajor studies