2022
Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment
Gunstad J, Disabato D, Shrestha R, Sanborn V, Mistler CB, Copenhaver MM. Latent profile analysis of data from the brief inventory of neurocognitive impairment (BINI) to develop neuro-cognitive profiles among opioid-dependent patients in drug treatment. Journal Of Addictive Diseases 2022, 41: 120-127. PMID: 35615880, PMCID: PMC9699904, DOI: 10.1080/10550887.2022.2080626.Peer-Reviewed Original ResearchConceptsLatent profile analysisNeurocognitive dysfunctionBrief inventoryNeuro-cognitive profileNeuro-cognitive impairmentSelf-reported neurocognitive symptomsProfile analysisOpioid-dependent patientsOpioid use disorderTreatment outcomesNeurocognitive impairmentDrug treatment outcomesMultiple domainsTreatment programUse disordersIntervention strategiesIndividual treatment needsNeurocognitive symptomsDrug treatment settingsTreatment settingsMethadone maintenance treatment programAccommodation strategiesModerate concernMaintenance treatment programOptimal treatment outcomes
2021
Adapting behavioural interventions to compensate for cognitive dysfunction in persons with opioid use disorder
Mistler CB, Shrestha R, Gunstad J, Sanborn V, Copenhaver MM. Adapting behavioural interventions to compensate for cognitive dysfunction in persons with opioid use disorder. General Psychiatry 2021, 34: e100412. PMID: 34504995, PMCID: PMC8370499, DOI: 10.1136/gpsych-2020-100412.Peer-Reviewed Original ResearchCognitive profileBehavioral interventionsCognitive dysfunctionAccommodation strategiesSimilar cognitive profileUse disordersFuture intervention researchSuch behavioral interventionsCognitive demandsExecutive functionBehavioral therapyCognitive functionInformation processingIntervention approachesIntervention researchIntervention placePatient's abilityOpioid use disorderInterventionTreatment outcomesPsychoeducationDisordersResearchMemoryAbility
2020
Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment
Copenhaver MM, Sanborn V, Shrestha R, Mistler C, Gunstad J. Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment. Journal Of Addictive Diseases 2020, 39: 166-174. PMID: 33047651, PMCID: PMC11395862, DOI: 10.1080/10550887.2020.1831129.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyDrug treatmentNeurocognitive dysfunctionNeurocognitive impairmentOpioid use disorderPossible clinical utilityAccommodation of patientsNIH ToolboxSubjective cognitive dysfunctionMaintenance therapyObjective cognitive testingSpecific neurocognitive profileTreatment outcomesCognitive dysfunctionClinical utilityUse disordersBrief inventoryObjective test performanceDysfunctionCognitive testingCutoff scoreNeurocognitive profileTest batteryObjective performanceImpairmentCognitive profiles in persons with opioid use disorder enrolled in methadone treatment
Sanborn V, Gunstad J, Shrestha R, Mistler CB, Copenhaver MM. Cognitive profiles in persons with opioid use disorder enrolled in methadone treatment. Applied Neuropsychology Adult 2020, 29: 462-468. PMID: 32463730, PMCID: PMC7704535, DOI: 10.1080/23279095.2020.1769099.Peer-Reviewed Original ResearchConceptsCognitive profileUse disordersTests of attentionDistinct cognitive profilesCognitive impairmentIntact cognitive functionOpioid use disorderExecutive functionCognitive phenotypesNIH ToolboxSubstance use treatmentCognitive functionImpaired groupAlcohol fourTreatment programPoor treatment outcomesUse treatmentMethadone maintenance treatment programImpairmentMaintenance treatment programDisordersUnderlying structurePersonsTreatment outcomesMore timeAddressing the Challenges of Neurocognitive Impairment (NCI) on Treatment Engagement
Shrestha R, Karki P, Copenhaver M. Addressing the Challenges of Neurocognitive Impairment (NCI) on Treatment Engagement. 2020, 109-140. DOI: 10.1002/9781119129530.ch6.Peer-Reviewed Original Research
2019
HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients
Shrestha R, Altice FL, Copenhaver MM. HIV-Related Stigma, Motivation to Adhere to Antiretroviral Therapy, and Medication Adherence Among HIV-Positive Methadone-Maintained Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 80: 166-173. PMID: 30383588, PMCID: PMC6331231, DOI: 10.1097/qai.0000000000001891.Peer-Reviewed Original ResearchConceptsOptimal ART adherenceAntiretroviral therapyMethadone-maintained patientsMethadone maintenance treatmentART adherenceMaintenance treatmentHIV treatment outcomesHIV-positive patientsOpioid agonist therapyMultivariable logistic regressionHIV risk behaviorsExplanatory pathwaysAgonist therapySuboptimal adherenceMedication adherenceHIV treatmentTreatment outcomesHIV stigmaPatientsLogistic regressionHIVPrevention initiativesTherapyAdherenceSignificant correlates
2017
Design and implementation of a factorial randomized controlled trial of methadone maintenance therapy and an evidence-based behavioral intervention for incarcerated people living with HIV and opioid dependence in Malaysia
Bazazi AR, Wickersham JA, Wegman MP, Culbert GJ, Pillai V, Shrestha R, Al-Darraji H, Copenhaver MM, Kamarulzaman A, Altice FL. Design and implementation of a factorial randomized controlled trial of methadone maintenance therapy and an evidence-based behavioral intervention for incarcerated people living with HIV and opioid dependence in Malaysia. Contemporary Clinical Trials 2017, 59: 1-12. PMID: 28479216, PMCID: PMC5557499, DOI: 10.1016/j.cct.2017.05.006.Peer-Reviewed Original ResearchConceptsMethadone maintenance therapyHIV transmission risk behaviorsMaintenance therapyTransmission risk behaviorsEvidence-based behavioral interventionsOpioid dependencePoor HIV treatment outcomesRisk behaviorsBehavioral interventionsHIV treatment outcomesProspective clinical trialsEvidence-based treatmentsHealth-related outcomesOpioid useTreatment receiptClinical trialsTreatment outcomesIncarcerated peopleTherapyStudy participantsFactorial trialHIVTrialsInterventionOutcomesA Self-report Measure to Detect Neurocognitive Impairment Among Incarcerated People Living with HIV in Malaysian Context: an Exploratory Factor Analysis
Shrestha R, Weikum D, Copenhaver M, Altice FL. A Self-report Measure to Detect Neurocognitive Impairment Among Incarcerated People Living with HIV in Malaysian Context: an Exploratory Factor Analysis. International Journal Of Mental Health And Addiction 2017, 15: 812-825. PMID: 29051714, PMCID: PMC5642920, DOI: 10.1007/s11469-017-9752-0.Peer-Reviewed Original ResearchNeuropsychological Impairment ScaleNeurocognitive impairmentHIV treatment outcomesNeuro-cognitive impairmentExploratory factor analysisSelf-report measuresNeurocognitive symptomsTreatment outcomesTreatment strategiesImpairment ScaleHIVScreening toolImpairmentPLWHEight-factor structureCronbach's alphaPrincipal axis factoringCognitive functioningOrthogonal varimax rotationPsychometric propertiesDrugsPresent studyMale prisonersIncarcerated peopleMore specific forms
2015
Sex-Related Differences in Self-Reported Neurocognitive Impairment among High-Risk Cocaine Users in Methadone Maintenance Treatment Program
Shrestha R, Huedo-Medina TB, Copenhaver MM. Sex-Related Differences in Self-Reported Neurocognitive Impairment among High-Risk Cocaine Users in Methadone Maintenance Treatment Program. Substance Use Research And Treatment 2015, 9: sart.s23332. PMID: 25861219, PMCID: PMC4363005, DOI: 10.4137/sart.s23332.Peer-Reviewed Original ResearchSelf-reported neurocognitive impairmentSex-related differencesAdverse health outcomesNeurocognitive impairmentNeuropsychological Impairment ScaleCocaine usersHealth outcomesTreatment programMethadone maintenance treatment programPossible sex-related differencesMaintenance treatment programSubstance abuse treatmentDifferential treatment outcomesNeuropsychological symptomsPatient awarenessTreatment outcomesImpairment ScaleClinical careHigher scoresPrevention strategiesCocaine cravingConfounding variablesSignificant associationGreater impairmentNeurocognitive deficits