2008
Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus
Kao H, Li P, Chao HM, Janoschka S, Pham K, Feng J, Mcewen BS, Greengard P, Pieribone VA, Porton B. Early involvement of synapsin III in neural progenitor cell development in the adult hippocampus. The Journal Of Comparative Neurology 2008, 507: 1860-1870. PMID: 18271024, DOI: 10.1002/cne.21643.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsBiomarkersCell DifferentiationCell ProliferationCell SurvivalDentate GyrusDNA-Binding ProteinsFemaleFluorescent Antibody TechniqueIntermediate Filament ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutNerve Growth FactorsNerve Tissue ProteinsNestinNeural Cell Adhesion Molecule L1Neuronal PlasticityNeuronsNuclear ProteinsSialic AcidsStem CellsSynapsinsTime FactorsTubulinConceptsHippocampal dentate gyrusWild-type miceAdult hippocampal dentate gyrusNeural progenitor cellsDentate gyrusNeural progenitor cell developmentProgenitor cellsProgenitor cell developmentSynapsin IIISynaptic vesicle-associated proteinsCell developmentSubgranular layerAdult neurogenesisKnockout miceSynaptic vesicle proteinsVesicle-associated proteinBrain regionsGyrusMiceNeurogenesisEarly involvementMarker of mitosisNovel roleVesicle proteinsProliferation
2003
Colocalization of synapsin and actin during synaptic vesicle recycling
Bloom O, Evergren E, Tomilin N, Kjaerulff O, Löw P, Brodin L, Pieribone VA, Greengard P, Shupliakov O. Colocalization of synapsin and actin during synaptic vesicle recycling. Journal Of Cell Biology 2003, 161: 737-747. PMID: 12756235, PMCID: PMC2199372, DOI: 10.1083/jcb.200212140.Peer-Reviewed Original ResearchConceptsSynaptic activityEndocytic zonesSynaptic vesicle recyclingSynaptic vesicle clustersMature nerve terminalsPool of vesiclesNerve terminalsActive synapsesGiant synapseVesicle recyclingAvailability of vesiclesSynapsin immunoreactivitySynaptic vesiclesVesicle clustersProminent reductionSynapsinSynapses
2002
Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain
Pieribone VA, Porton B, Rendon B, Feng J, Greengard P, Kao H. Expression of synapsin III in nerve terminals and neurogenic regions of the adult brain. The Journal Of Comparative Neurology 2002, 454: 105-114. PMID: 12412137, DOI: 10.1002/cne.10417.Peer-Reviewed Original ResearchConceptsNerve terminalsAdult brainNeurogenic regionsHippocampal dentate gyrusMarker of immatureSynapsin IIIRostral migratory streamIII-positive neuronsAdult mouse brainImmature neuronsAdult neurogenesisDentate gyrusCell adhesion moleculeOlfactory bulbSynaptic vesicle proteinsMouse brainMigratory streamNeurotransmitter releaseCell bodiesAdhesion moleculesSynapsin IBrainNeuronsPunctate stainingGreat regional variationA protein kinase A–dependent molecular switch in synapsins regulates neurite outgrowth
Kao HT, Song HJ, Porton B, Ming GL, Hoh J, Abraham M, Czernik AJ, Pieribone VA, Poo MM, Greengard P. A protein kinase A–dependent molecular switch in synapsins regulates neurite outgrowth. Nature Neuroscience 2002, 5: 431-437. PMID: 11976703, DOI: 10.1038/nn840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBucladesineCells, CulturedConserved SequenceCyclic AMP-Dependent Protein KinasesEmbryo, NonmammalianEnzyme ActivatorsEnzyme InhibitorsGenes, ReporterMicroinjectionsMolecular Sequence DataMutagenesis, Site-DirectedNeuritesNeuronsPhosphorylationRNA, MessengerSequence Homology, Amino AcidSynapsinsXenopus laevisConceptsProtein kinase ANeurite outgrowthCAMP/protein kinase APhospho-specific antibodiesSingle amino acid residueX. laevis embryosAmino acid residuesDependent molecular switchPhosphorylation of synapsinCyclic AMPEmbryonic neuronal culturesNeuronal cell lineProtein kinaseConstitutive phosphorylationKinase AMolecular approachesMolecular switchAcid residuesLaevis embryosPKA inhibitorPotential molecular approachPhosphorylationGrowth-promoting actionCell linesSynapsin
1999
Molecular evolution of the synapsin gene family
Kao H, Porton B, Hilfiker S, Stefani G, Pieribone V, DeSalle R, Greengard P. Molecular evolution of the synapsin gene family. Journal Of Experimental Zoology 1999, 285: 360-377. PMID: 10578110, DOI: 10.1002/(sici)1097-010x(19991215)285:4<360::aid-jez4>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsSynapsin gene familyGene familySynapsin genesGene duplication eventsEvolution of vertebratesVariety of invertebratesSynaptic vesicle proteinsDuplication eventsMolecular evolutionMolecular phylogenyAncestral conditionHigher vertebratesFruit flyRegulation of neurotransmissionVesicle proteinsAdditional speciesProtein sequencesLongfin squidNeuronal phosphoproteinSynapsinVertebratesSpeciesGenesJ. ExpFamilySynapsins as regulators of neurotransmitter release
Hilfiker S, Pieribone V, Czernik A, Kao H, Augustine G, Greengard P. Synapsins as regulators of neurotransmitter release. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 269-279. PMID: 10212475, PMCID: PMC1692497, DOI: 10.1098/rstb.1999.0378.Peer-Reviewed Original ResearchConceptsSynapsin functionSynaptic vesiclesSynaptic vesicle life cycleReserve poolNeuron-specific phosphoproteinNeurotransmitter releaseSelective disruptionVesicle dockingMultigene familyNumerous proteinsCytoskeletal meshworkAbundant proteinsCytoskeletal proteinsMolecular mechanismsProtein componentsSynapsinSynapse formationPresynaptic nerve terminalsVesiclesProteinSecond roleRelease of neurotransmittersLife cycleCurrent understandingSquid giant synapse
1995
Distinct pools of synaptic vesicles in neurotransmitter release
Pieribone V, Shupliakov O, Brodin L, Hilfiker-Rothenfluh S, Czernik A, Greengard P. Distinct pools of synaptic vesicles in neurotransmitter release. Nature 1995, 375: 493-497. PMID: 7777058, DOI: 10.1038/375493a0.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseCellular secretory systemSynaptic vesiclesLow-frequency stimulationSynaptic release sitesRelease of neurotransmittersHigh-frequency burstsNeuron-specific proteinSynapsin antibodiesPool of vesiclesDistal poolNerve terminalsMarked depressionVesicular releasePresynaptic membraneSynapsinHigh rateClusters of vesiclesApparent effectReleaseSecretory systemSuch protein familiesNeurotransmittersRelease sites