2013
Adaptation Dynamics in Densely Clustered Chemoreceptors
Pontius W, Sneddon MW, Emonet T. Adaptation Dynamics in Densely Clustered Chemoreceptors. PLOS Computational Biology 2013, 9: e1003230. PMID: 24068908, PMCID: PMC3777915, DOI: 10.1371/journal.pcbi.1003230.Peer-Reviewed Original ResearchConceptsOrganisms senseChemotaxis pathwayTransmembrane receptorsNutrient gradientsReceptor methylationProtein abundanceReceptor substrateBacterial chemotaxisReceptor activityModification systemPathway constituentsEscherichia coliIndividual cellsEnvironmental stimuliFunctional robustnessExpression levelsMechanistic relationshipEnzymeModel systemEnzyme kineticsChemotaxis systemPrecise adaptationAdaptation dynamicsReceptor modificationModification kinetics
2010
Efficient modeling, simulation and coarse-graining of biological complexity with NFsim
Sneddon MW, Faeder JR, Emonet T. Efficient modeling, simulation and coarse-graining of biological complexity with NFsim. Nature Methods 2010, 8: 177-183. PMID: 21186362, DOI: 10.1038/nmeth.1546.Peer-Reviewed Original ResearchProcessivity of peptidoglycan synthesis provides a built-in mechanism for the robustness of straight-rod cell morphology
Sliusarenko O, Cabeen MT, Wolgemuth CW, Jacobs-Wagner C, Emonet T. Processivity of peptidoglycan synthesis provides a built-in mechanism for the robustness of straight-rod cell morphology. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 10086-10091. PMID: 20479277, PMCID: PMC2890421, DOI: 10.1073/pnas.1000737107.Peer-Reviewed Original Research
2009
Understanding Modularity in Molecular Networks Requires Dynamics
Alexander RP, Kim PM, Emonet T, Gerstein MB. Understanding Modularity in Molecular Networks Requires Dynamics. Science Signaling 2009, 2: pe44. PMID: 19638611, PMCID: PMC4243459, DOI: 10.1126/scisignal.281pe44.Peer-Reviewed Original ResearchConceptsMolecular networksBiological networksMolecular network analysisAnalysis of modularityCellular machinesMolecular partsSystems biologyFunctional analysisGenome sequencingCellular behaviorCollective functionsMolecular interactionsSmall moleculesNetwork analysisRecent advancesIntense researchBiologyFundamental goalSequencingMajor advancesMoleculesInteractionIsolationModularity
2008
Minimally invasive determination of mRNA concentration in single living bacteria
Guet CC, Bruneaux L, Min TL, Siegal-Gaskins D, Figueroa I, Emonet T, Cluzel P. Minimally invasive determination of mRNA concentration in single living bacteria. Nucleic Acids Research 2008, 36: e73-e73. PMID: 18515347, PMCID: PMC2475643, DOI: 10.1093/nar/gkn329.Peer-Reviewed Original Research