2009
A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure
Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure. Cell 2009, 138: 976-989. PMID: 19737523, PMCID: PMC2768582, DOI: 10.1016/j.cell.2009.06.051.Peer-Reviewed Original ResearchConceptsSerotonergic neuronsHypothalamic neuronsBone massEnergy expenditureVentromedial hypothalamic neuronsBone mass accrualSerotonin-dependent mechanismRegulation of appetiteEnergy expenditure phenotypesSpecific hypothalamic neuronsHtr2c receptorLeptin deficiencyArcuate neuronsLeptin inhibitionSerotonin synthesisLeptin receptorLeptin regulationLeptinNeuronsAppetiteReceptorsEnergy metabolismBrainBoneMolecular basis
2003
Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats
Parducz A, Zsarnovszky A, Naftolin F, Horvath TL. Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats. Neuroscience 2003, 117: 791-794. PMID: 12654332, DOI: 10.1016/s0306-4522(02)00967-3.Peer-Reviewed Original ResearchConceptsAxo-somatic contactsArcuate nucleusSynaptic plasticityGABAergic axo-somatic synapsesMorphological synaptic plasticityAxo-somatic synapsesEffects of estradiolSynapse quantificationArcuate neuronsTracer FluorogoldGonadal steroidsAnterior pituitaryAdult ratsHypophysiotropic neuronsMedian eminenceNervous systemTransient decreaseSystemic applicationNeuroendocrine cellsDisector methodNeuronsNumerical densityEstradiolFluorogoldCells