Featured Publications
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte O, Piva M, Anderson KM, Tringides M, Holmes AJ, Chang SWC. Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 5247-5252. PMID: 28461466, PMCID: PMC5441805, DOI: 10.1073/pnas.1702725114.Peer-Reviewed Original ResearchConceptsSocial attentionMutual eye contactSocial cognitionReward receiptParticular social importanceEfficacy of oxytocinEye contactSocial dysfunctionOpioid antagonismSocial contextGaze interactionHuman brainEntire sessionOxytocinΚ-opioid receptor geneFacial regionOT geneAttentionCognitionSocial importanceStrong effectMonkeysOpioid systemSessionsContext
2021
Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates
Weinberg-Wolf HB, Fagan N, Dal Monte O, Chang SWC. Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates. Journal Of Neuroscience 2021, 42: 670-681. PMID: 34862190, PMCID: PMC8805615, DOI: 10.1523/jneurosci.0413-21.2021.Peer-Reviewed Original ResearchConceptsSocial gaze behaviorAbility of monkeysSocial gazeGaze behaviorMotivational stateControl imagesReaction timeCentral serotonin levelsNonhuman primatesSocial orientingGaze responsesSerotonergic interventionsModulatory relationshipCausal evidenceEye movementsTranslational insightsGazeDistinct aspectsDisruptive effectsBehavioral changesSerotonergic systemPupil constrictionCausal impactCentral serotoninFlexible orientation
2018
The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque
Weinberg-Wolf H, Fagan NA, Anderson GM, Tringides M, Dal Monte O, Chang SWC. The effects of 5-hydroxytryptophan on attention and central serotonin neurochemistry in the rhesus macaque. Neuropsychopharmacology 2018, 43: 1589-1598. PMID: 29463909, PMCID: PMC5983545, DOI: 10.1038/s41386-017-0003-7.Peer-Reviewed Original ResearchConceptsSerotonergic interventionsSalient facial featuresCentral serotonergic functioningCisternal cerebrospinal fluidBaseline attentionCognitive operationsSerotonin's roleIndividual differencesBi-directional effectsAutonomic arousalSaline sessionsImmediate serotonin precursorEngaged individualsBehavioral impairmentsFacial featuresSerotonergic functioningStimulus animalsRole of serotoninPupil sizeAnxietyPsychiatric disordersSerotonin neurochemistrySerotoninergic functionSerotonin effectsCSF concentrations