Featured Publications
Medial prefrontal D1 dopamine neurons control food intake
Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, M Grimaldi D, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience 2014, 17: 248-253. PMID: 24441680, PMCID: PMC3968853, DOI: 10.1038/nn.3625.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaAnalysis of VarianceAnimalsBiophysicsCalcium-Calmodulin-Dependent Protein Kinase Type 2ChannelrhodopsinsEatingElectric StimulationFemaleFood DeprivationFunctional LateralityGene Expression RegulationIn Vitro TechniquesLuminescent ProteinsMaleMembrane PotentialsMiceMice, Inbred C57BLMice, TransgenicNeural InhibitionNeural PathwaysNeuronsOptogeneticsPatch-Clamp TechniquesPhotic StimulationPrefrontal CortexReceptors, Dopamine D1Time Factors
2024
The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
Jiang C, DiLeone R, Pittenger C, Duman R. The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions. Translational Psychiatry 2024, 14: 90. PMID: 38346984, PMCID: PMC10861497, DOI: 10.1038/s41398-024-02796-0.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexAction of ketamineEndogenous opioid systemAntidepressant-like actionOpioid systemB-endorphinKetamine treatmentAntidepressant-like actions of ketamineBehavioral actions of ketamineAntidepressant actions of ketamineBehavioral effects of ketamineSingle dose of ketamineAntidepressant-like effectsLevels of B-endorphinAcute systemic administrationEffects of ketamineDose of ketamineOpioid receptor antagonistAntidepressant actionPrefrontal cortexActivation of opioid receptorsBehavioral effectsBehavioral actionsCompetitive opioid receptor antagonistOpioid receptors
2019
Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
Hare BD, Shinohara R, Liu RJ, Pothula S, DiLeone RJ, Duman RS. Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects. Nature Communications 2019, 10: 223. PMID: 30644390, PMCID: PMC6333924, DOI: 10.1038/s41467-018-08168-9.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexAntidepressant effectsPyramidal cellsNovel rapid-acting antidepressantsRapid antidepressant effectsRapid-acting antidepressantsRapid antidepressant responseRapid antidepressant actionsAntidepressant actionAntidepressant responsePyramidal neuronsTherapeutic responseDRD2 dopamine receptorAnxiolytic responseDopamine receptorsSomatic stimulationTarget neuronsImpaired functionMajor subtypesOptogenetic stimulationParticular subtypeDownstream circuitryPrefrontal cortexKetamineNeurons
2012
Gene Profiling Reveals a Role for Stress Hormones in the Molecular and Behavioral Response to Food Restriction
Guarnieri DJ, Brayton CE, Richards SM, Maldonado-Aviles J, Trinko JR, Nelson J, Taylor JR, Gourley SL, DiLeone RJ. Gene Profiling Reveals a Role for Stress Hormones in the Molecular and Behavioral Response to Food Restriction. Biological Psychiatry 2012, 71: 358-365. PMID: 21855858, PMCID: PMC3237832, DOI: 10.1016/j.biopsych.2011.06.028.Peer-Reviewed Original ResearchConceptsFood restrictionGene expressionExpression changesStress-responsive genesBrain regionsWhole-genome microarraysPersistent expression changesGene expression profilesMale C57BL/6J miceAdministration of corticosteroneVentral tegmental areaIntact adrenal glandsEnzyme-linked immunosorbentMedial prefrontal cortexQuantitative polymerase chain reactionResponsive genesNonrestricted animalsDaily injectionsAdrenal glandC57BL/6J miceExpression profilesPlasma levelsPolymerase chain reactionCORT treatmentTegmental area