2015
Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology
2014
Cortical oscillations arise from contextual interactions that regulate sparse coding
Jadi MP, Sejnowski TJ. Cortical oscillations arise from contextual interactions that regulate sparse coding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6780-6785. PMID: 24742427, PMCID: PMC4020078, DOI: 10.1073/pnas.1405300111.Peer-Reviewed Original ResearchConceptsInhibitory neuronsFiring ratePower of oscillationsMonosynaptic inputDisynaptic pathwayHigher firing ratesLow firing ratesDisynaptic inputCortical circuitsSynaptic plasticityCortical stateCortical oscillationsModel cortical circuitSensory stimuliBehavioral statesStimulationSensory inputComplex natural stimuliInhibitory controlCortexNeuronsSpike timingActivity balanceNatural stimuliParadoxical experimental findings