Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants
Kadriu B, Greenwald M, Henter ID, Gilbert JR, Kraus C, Park LT, Zarate CA. Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants. The International Journal Of Neuropsychopharmacology 2020, 24: 8-21. PMID: 33252694, PMCID: PMC7816692, DOI: 10.1093/ijnp/pyaa087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntidepressive AgentsDepressive DisorderExcitatory Amino Acid AntagonistsHallucinogensHumansKetamineSerotonin AgentsConceptsKetamine researchSerotonergic psychedelicsAntidepressant effectsAntidepressant efficacyRapid-acting antidepressantsRapid acting antidepressantsGlutamatergic modulator ketamineCortical network activityDownstream pharmacological effectsActivity-dependent mannerAcute alterationsTherapeutic responseNeuroplastic effectsGlutamatergic pathwaysPharmacological effectsKetaminePsychoactive componentTherapeutic relevanceAntidepressantsDownstream mechanismsPsychoactive effectsMolecular effectsNetwork activityCommon mechanismEfficacy