2023
Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile
Johnston J, Greenwald M, Henter I, Kraus C, Mkrtchian A, Clark N, Park L, Gold P, Zarate C, Kadriu B. Inflammation, stress and depression: An exploration of ketamine’s therapeutic profile. Drug Discovery Today 2023, 28: 103518. PMID: 36758932, PMCID: PMC10050119, DOI: 10.1016/j.drudis.2023.103518.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnique therapeutic mechanismTherapeutic profileCentral nervous system inflammationHypothalamic pituitary adrenal axisNervous system inflammationRapid-acting antidepressantsTreatment-resistant depressionAnti-inflammatory actionPeripheral inflammatory biomarkersSystem inflammationInflammatory biomarkersProinflammatory stateCytokine suppressionAdrenal axisKynurenine pathwayTherapeutic effectTherapeutic mechanismAnimal modelsInflammationDepressionAntidepressantsKetamineFurther investigationBiomarkers
2020
Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants
Kadriu B, Greenwald M, Henter ID, Gilbert JR, Kraus C, Park LT, Zarate CA. Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants. The International Journal Of Neuropsychopharmacology 2020, 24: 8-21. PMID: 33252694, PMCID: PMC7816692, DOI: 10.1093/ijnp/pyaa087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsKetamine researchSerotonergic psychedelicsAntidepressant effectsAntidepressant efficacyRapid-acting antidepressantsRapid acting antidepressantsGlutamatergic modulator ketamineCortical network activityDownstream pharmacological effectsActivity-dependent mannerAcute alterationsTherapeutic responseNeuroplastic effectsGlutamatergic pathwaysPharmacological effectsKetaminePsychoactive componentTherapeutic relevanceAntidepressantsDownstream mechanismsPsychoactive effectsMolecular effectsNetwork activityCommon mechanismEfficacy