A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors
Alsaloum M, Kazi R, Gan Q, Amin J, Wollmuth LP. A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors. Journal Of Neuroscience 2016, 36: 2617-2622. PMID: 26937003, PMCID: PMC4879209, DOI: 10.1523/jneurosci.2667-15.2016.Peer-Reviewed Original ResearchConceptsIon channelsIonotropic glutamate receptorsHydrophobic boxDiverse animal phylaExtensive sequence alignmentDiverse animal speciesGlutamate-gated ion channelsSingle amino acid differenceExchange mutationAmino acid differencesFast excitatory synaptic transmissionAvailable structural informationAnimal phylaTransmembrane helicesSequence alignmentGlutamate receptorsAcid differencesMolecular determinantsGluN2 subunitsAnimal speciesExtracellular interfaceMotifSynaptic functionReceptor functionNervous system