2020
Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice
Tan Y, Hang F, Liu ZW, Stoiljkovic M, Wu M, Tu Y, Han W, Lee AM, Kelley C, Hajos M, Lu L, de Lecea L, de Araujo I, Picciotto M, Horvath TL, Gao XB. Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. Journal Of Clinical Investigation 2020, 130: 4985-4998. PMID: 32516139, PMCID: PMC7456212, DOI: 10.1172/jci130889.Peer-Reviewed Original ResearchConceptsHcrt cellsObese miceDiet-induced obese miceObese male miceExcessive energy intakeNeuropeptide hypocretin/orexinHypocretin/orexinHcrt neuronsMale miceHcrt systemClinical studiesCommon causeSynaptic transmissionObese animalsEnergy intakeAcute stressCognitive functionSalient stimuliAlters responsesExact mechanismMiceHomeostatic regulationNeuronal networksBehavioral changesNeurons
2007
Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure
Jacobsen LK, Picciotto MR, Heath CJ, Frost SJ, Tsou KA, Dwan RA, Jackowski MP, Constable RT, Mencl WE. Prenatal and Adolescent Exposure to Tobacco Smoke Modulates the Development of White Matter Microstructure. Journal Of Neuroscience 2007, 27: 13491-13498. PMID: 18057207, PMCID: PMC6673092, DOI: 10.1523/jneurosci.2402-07.2007.Peer-Reviewed Original ResearchConceptsAuditory processingAdolescent exposureWhite matter microstructureAuditory attention taskSymptoms of inattentionAuditory processing deficitsNicotine-induced disruptionAuditory attentionAttention taskPrenatal exposureProcessing deficitsAuditory signalsAdolescent smokersAdolescent smokingTobacco smokeFractional anisotropyDiffusion tensor anisotropyMaternal smokingCorticofugal fibersInternal capsuleParent educationDevelopmental disruptionReaction timeInternal capsule fibersAnatomical magnetic resonance images
2002
Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics
Picciotto MR, Corrigall WA. Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics. Journal Of Neuroscience 2002, 22: 3338-3341. PMID: 11978809, PMCID: PMC6758396, DOI: 10.1523/jneurosci.22-09-03338.2002.Peer-Reviewed Original ResearchConceptsAction of nicotineNicotine addictionNicotinic acetylcholine receptor subunitsAcetylcholine receptor subunitsStudies of miceSerotonergic nucleiNicotine effectsDopaminergic activityDopaminergic systemNicotine dependenceBrainstem cholinergicNeural circuitsNeuronal systemsReceptor subunitsBehavioral effectsNicotineAddictionRecent studiesNeural systemsInitial observationsCholinergicGABAergicMolecular geneticsMice
1998
Brain nicotinic receptors: structure and regulation, role in learning and reinforcement1Published on the World Wide Web on 24 October 1997.1
Changeux J, Bertrand D, Corringer P, Dehaene S, Edelstein S, Léna C, Le Novère N, Marubio L, Picciotto M, Zoli M. Brain nicotinic receptors: structure and regulation, role in learning and reinforcement1Published on the World Wide Web on 24 October 1997.1. Brain Research Reviews 1998, 26: 198-216. PMID: 9651527, DOI: 10.1016/s0165-0173(97)00040-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements