2022
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA
Wong KH, Muddasani V, Peterson C, Sheibani N, Arkin C, Cheong I, Majersik JJ, Biffi A, Petersen N, Falcone GJ, Sansing LH, de Havenon AH. Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA. American Journal Of Hypertension 2022, 36: 144-147. PMID: 36315490, PMCID: PMC11484580, DOI: 10.1093/ajh/hpac122.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisBiomarkersBlood PressureFemaleHumansHypertensionInflammationInterleukin-6MaleMiddle AgedConceptsBlood pressure variabilityHigh blood pressure variabilitySerum inflammatory markersPlasmin-antiplasmin complexC-reactive proteinInterleukin-6Inflammatory markersBlood pressureStudy visitPressure variabilityBaseline serum IL-6Visit blood pressure variabilityLipid-lowering medicationsMean blood pressureSerum IL-6Markers of inflammationSystolic blood pressureBaseline study visitBody mass indexOnly IL-6Major vascular diseasesMulti-Ethnic StudyBaseline serum biomarkersPatient age categoryPost Hoc Analysis
2021
Early Inflammatory Cytokine Expression in Cerebrospinal Fluid of Patients with Spontaneous Intraventricular Hemorrhage
Ziai WC, Parry-Jones AR, Thompson CB, Sansing LH, Mullen MT, Murthy SB, Mould A, Nekoovaght-Tak S, Hanley DF. Early Inflammatory Cytokine Expression in Cerebrospinal Fluid of Patients with Spontaneous Intraventricular Hemorrhage. Biomolecules 2021, 11: 1123. PMID: 34439789, PMCID: PMC8394793, DOI: 10.3390/biom11081123.Peer-Reviewed Original ResearchConceptsIL-10IL-6IL-1βIL-8Cerebrospinal fluidIntraventricular hemorrhageDay 1IVH volumeCerebral inflammatory responsePerihematomal edema volumePro-inflammatory markersExternal ventricular drainageInflammatory cytokine expressionSpontaneous intraventricular hemorrhageChemokine ligands CCL2Tumor necrosis factorEnzyme-linked immunosorbentCSF cytokinesRelative PHELigand CCL2Obstructive hydrocephalusVentricular drainageEdema volumeCytokine expressionICH volumeIntracerebral Hemorrhage in Patients With COVID-19
Leasure AC, Khan YM, Iyer R, Elkind MSV, Sansing LH, Falcone GJ, Sheth KN. Intracerebral Hemorrhage in Patients With COVID-19. Stroke 2021, 52: e321-e323. PMID: 34082576, PMCID: PMC8238884, DOI: 10.1161/strokeaha.121.034215.Peer-Reviewed Original ResearchAdolescentAdultAge FactorsAgedAnticoagulantsCerebral HemorrhageCOVID-19C-Reactive ProteinExtracorporeal Membrane OxygenationFemaleHeart Disease Risk FactorsHospital MortalityHospitalizationHumansIntensive Care UnitsInterleukin-6MaleMiddle AgedRegistriesRespiration, ArtificialRisk FactorsSARS-CoV-2Sex FactorsUnited StatesYoung AdultAssociation of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage
Leasure AC, Kuohn LR, Vanent KN, Bevers MB, Kimberly WT, Steiner T, Mayer SA, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage. Stroke 2021, 52: 1733-1740. PMID: 33682454, PMCID: PMC8085132, DOI: 10.1161/strokeaha.120.032888.Peer-Reviewed Original ResearchConceptsIL-6 levelsPerihematomal edema volumeIntracerebral hemorrhageIL-6Edema volumeFunctional outcomeICH locationICH volumeTreatment groupsSerum IL-6 levelsBaseline ICHAcute brain injuryLarge intracerebral hemorrhageSerum IL-6Predictors of outcomeSpontaneous intracerebral hemorrhageRankin ScalePoor outcomeProinflammatory cytokinesTrial populationBrain injurySecondary analysisStrong associationFast trialsOutcomes