2009
Reperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
2004
Hypoperfusion without stroke alters motor activation in the opposite hemisphere
Krakauer JW, Radoeva PD, Zarahn E, Wydra J, Lazar RM, Hirsch J, Marshall RS. Hypoperfusion without stroke alters motor activation in the opposite hemisphere. Annals Of Neurology 2004, 56: 796-802. PMID: 15562431, DOI: 10.1002/ana.20286.Peer-Reviewed Original ResearchConceptsIpsilateral activationMiddle cerebral artery diseaseCerebral artery diseaseLarge vessel diseaseAge-matched controlsMotor-related areasNormal motor performanceFunctional magnetic resonanceHemodynamic compromiseVasomotor reactivityArtery diseaseHemispheric hypoperfusionCortical reorganizationInternal carotidHand contralateralPatientsMotor activationMotor tasksMotor performanceHypoperfusionHemispheric activationUnique activationDiseaseActivationMagnetic resonance