2023
Quantification of inter-brain coupling: A review of current methods used in haemodynamic and electrophysiological hyperscanning studies
Hakim U, De Felice S, Pinti P, Zhang X, Noah J, Ono Y, Burgess P, Hamilton A, Hirsch J, Tachtsidis I. Quantification of inter-brain coupling: A review of current methods used in haemodynamic and electrophysiological hyperscanning studies. NeuroImage 2023, 280: 120354. PMID: 37666393, DOI: 10.1016/j.neuroimage.2023.120354.Peer-Reviewed Original ResearchConceptsInter-brain couplingHyperscanning studyFunctional magnetic resonanceBrain imaging modalitiesSocial neuroscienceCognitive mechanismsSocial anxietyBrain couplingCognitive researchSocial interactionHyperscanningMental healthDifferent modalitiesMagnetoencephalographyDevelopmental conditionsElectroencephalographyMore participantsParticipantsAutismNeuroscienceFNIRSAnxietyBrainModalitiesSchizophrenia
2022
Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder
Fertuck E, Stanley B, Kleshchova O, Mann J, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Grinband J. Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 8: 651-659. PMID: 36868964, PMCID: PMC10388534, DOI: 10.1016/j.bpsc.2022.11.006.Peer-Reviewed Original ResearchConceptsBorderline personality disorderRejection distressFunctional magnetic resonancePrefrontal cortex responsesCortex responsesPrefrontal cortexPersonality disorderControl participantsWhole-brain responsesNeural responsesFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexHealthy control participantsUnivariate analysisMagnetic resonanceBPD groupResonance imagingNovel functional magnetic resonanceGroup differencesRostromedial prefrontal cortexNeural substratesBrain activityDistressNeural mechanisms
2015
fMRI Validation of fNIRS Measurements During a Naturalistic Task
Noah JA, Ono Y, Nomoto Y, Shimada S, Tachibana A, Zhang X, Bronner S, Hirsch J. fMRI Validation of fNIRS Measurements During a Naturalistic Task. Journal Of Visualized Experiments 2015, 52116. PMID: 26132365, PMCID: PMC4544944, DOI: 10.3791/52116.Peer-Reviewed Original ResearchConceptsNaturalistic tasksBrain activityVideo game taskTask-related increasesFunctional magnetic resonanceFunctional brain activityFull-body activitiesDance Dance RevolutionFMRI scanningPsychophysical tasksNeural mechanismsGame taskFMRI procedureFNIRS experimentFNIRS measurementsFMRINaturalistic behaviorsFMRI signalsFNIRSSimple fingerTaskParadigmNeural recordingsFindingsBehaviorBrain activity classifies adolescents with and without a familial history of substance use disorders
Qiao J, Wang Z, Geronazzo-Alman L, Amsel L, Duarte C, Lee S, Musa G, Long J, He X, Doan T, Hirsch J, Hoven CW. Brain activity classifies adolescents with and without a familial history of substance use disorders. Frontiers In Human Neuroscience 2015, 9: 219. PMID: 25954186, PMCID: PMC4406072, DOI: 10.3389/fnhum.2015.00219.Peer-Reviewed Original ResearchAnterior cingulate cortexSubstance use disordersPrefrontal cortexEmotional conflictBrain circuitsEmotional Stroop taskPotential neurobiological mechanismsFunctional magnetic resonanceUse disordersGroup-level analysisStroop taskVentral tegmental areaNeural substratesCognitive behaviorNeurobiological mechanismsBrain activityEffective connectivityEndophenotype markersCingulate cortexBrain featuresGranger causality indexWeak connectivityFH- adolescentsAdolescentsCausal interactions
2012
Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity
Pantazatos SP, Talati A, Pavlidis P, Hirsch J. Decoding Unattended Fearful Faces with Whole-Brain Correlations: An Approach to Identify Condition-Dependent Large-Scale Functional Connectivity. PLOS Computational Biology 2012, 8: e1002441. PMID: 22479172, PMCID: PMC3315448, DOI: 10.1371/journal.pcbi.1002441.Peer-Reviewed Original ResearchConceptsFearful facesEmotional expressionBilateral middle temporal gyrusThreat-related stimuliUnattended fearful facesLarge-scale functional connectivityMultiple functional connectionsFunctional magnetic resonanceWhole-brain patternsMiddle temporal gyrusWhole-brain correlationActive research goalNeutral facesEmotion processingFear perceptionImplicit fearImplicit presentationAngular gyrusChance accuracyTemporal gyrusBrain activityFace presentationPrefrontal cortexParietal regionsFunctional connectivityNeural systems for speech and song in autism
Lai G, Pantazatos SP, Schneider H, Hirsch J. Neural systems for speech and song in autism. Brain 2012, 135: 961-975. PMID: 22298195, PMCID: PMC3286324, DOI: 10.1093/brain/awr335.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAgingAnisotropyAttentionAutistic DisorderBrainChildDiffusion Tensor ImagingFemaleFunctional LateralityHead MovementsHumansImage Processing, Computer-AssistedInterview, PsychologicalLanguageMagnetic Resonance ImagingMaleMusicNerve NetNeural PathwaysNeuropsychological TestsPhotic StimulationRecruitment, NeurophysiologicalSpeechYoung AdultConceptsInferior frontal gyrusLeft inferior frontal gyrusFrontal gyrusAutistic childrenNeural systemsArcuate fasciculusFunctional magnetic resonanceSuperior temporal gyrusAge-matched control childrenLeft arcuate fasciculusPassive auditory stimulationMusic abilityLanguage disabilitySong conditionTemporal gyrusSpeech stimulationAuditory stimulationAutismFunctional connectivityNeural organizationBrain regionsSpeechControl childrenGyrusAutistic
2011
Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder
Schneier FR, Pomplun M, Sy M, Hirsch J. Neural response to eye contact and paroxetine treatment in generalized social anxiety disorder. Psychiatry Research 2011, 194: 271-278. PMID: 22047726, PMCID: PMC3230304, DOI: 10.1016/j.pscychresns.2011.08.006.Peer-Reviewed Original ResearchConceptsParoxetine treatmentInferior parietal lobuleGeneralized social anxiety disorderNeural responsesPosterior cingulateParietal lobuleAnxiety disordersGSAD patientsEye contactMiddle occipital cortexMiddle frontal gyrusFunctional magnetic resonanceSymptomatic improvementHealthy comparison participantsOccipital cortexSocial anxiety disorderSymptom reductionAnterior cingulatePatientsUnmedicated adultsParahippocampal cortexNeural circuitrySupramarginal gyrusFrontal gyrusCingulateDifferences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration
Mackay M, Bussa MP, Aranow C, Uluğ AM, Volpe BT, Huerta PT, Argyelan M, Mandel A, Hirsch J, Diamond B, Eidelberg D. Differences in Regional Brain Activation Patterns Assessed by Functional Magnetic Resonance Imaging in Patients with Systemic Lupus Erythematosus Stratified by Disease Duration. Molecular Medicine 2011, 17: 1349-1356. PMID: 21953419, PMCID: PMC3321819, DOI: 10.2119/molmed.2011.00185.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusBlood-brain barrierFunctional magnetic resonance imagingTissue damageDisease durationBrain activation patternsLupus erythematosusST groupSystemic Lupus International Collaborating Clinics Damage IndexActivation patternsFearful face paradigmRegional brain activation patternsDuration of diseaseRegional brain abnormalitiesCentral nervous systemMagnetic resonance imagingFunctional magnetic resonanceCorticosteroid dosesDisease activityComorbid diseasesSLE patientsImmune cellsVascular diseaseBrain injuryBrain abnormalitiesSpeech Stimulation during Functional MR Imaging as a Potential Indicator of Autism
Lai G, Schneider HD, Schwarzenberger JC, Hirsch J. Speech Stimulation during Functional MR Imaging as a Potential Indicator of Autism. Radiology 2011, 260: 521-30. PMID: 21628495, DOI: 10.1148/radiol.11101576.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusControl subjectsSpeech stimulationFunctional MR imagingFunctional MR imaging activationFunctional magnetic resonanceAutistic subjectsMR imagingPrimary auditory cortexWilcoxon rank sum testInstitutional review boardMagnetic resonanceSpread of activityTwo-sample t-testRank sum testUnivariate general linear model analysisProspective studyMR evaluationAuditory cortexGeneral linear model analysisControl groupObjective indicatorsTemporal gyrusInformed consentReview boardIncreased neuronal activity in response to food stimuli after periods of reduced sleep relative to habitual sleep in normal weight men and women
McReynolds A, Roberts A, Sy M, Hirsch J, St‐Onge M. Increased neuronal activity in response to food stimuli after periods of reduced sleep relative to habitual sleep in normal weight men and women. The FASEB Journal 2011, 25: 328.2-328.2. DOI: 10.1096/fasebj.25.1_supplement.328.2.Peer-Reviewed Original ResearchFood stimuliHabitual sleepCognitive control mechanismsNormal-weight menNon-food stimuliFunctional magnetic resonanceSleep durationSuperior frontal gyrusShort sleep conditionShort sleepImages of foodAnterior cingulate gyrusWeight menFrontal gyrusReward salienceBrain activityShort sleep durationSleep conditionsPrevalence of obesityCingulate gyrusReduced sleepStimuliH sleepSleepGyrus
2010
A translational bridge between mouse and human models of learned safety
Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Annals Of Medicine 2010, 42: 127-134. PMID: 20121549, DOI: 10.3109/07853890903583666.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexNeural circuitryPrefrontal cortexAnimal experimentsTranslational bridgeFunctional magnetic resonanceParallel groupSafety signalsPupillary constrictionNoxious stimuliUnderlying neural circuitryHuman studiesExperimental animalsHuman modelNeural connectionsAnimal protocolsMiceCaudate responseNeutral stimuliNeural responsesNeural substratesDiffusion tensorAmygdalaCortexMolecular mechanisms
2009
Reperfusion normalizes motor activation patterns in large‐vessel disease
Chmayssani M, Lazar RM, Hirsch J, Marshall RS. Reperfusion normalizes motor activation patterns in large‐vessel disease. Annals Of Neurology 2009, 65: 203-208. PMID: 19259970, PMCID: PMC2653600, DOI: 10.1002/ana.21554.Peer-Reviewed Original ResearchConceptsMotor activation patternsVasomotor reactivityActivation patternsInterest analysisIpsilateral motor activationLarge vessel diseaseNormal neurological functionHealthy control subjectsHigh-grade stenosisBlood oxygen level-dependent (BOLD) signalNormal blood flowDynamic functional reorganizationLevel-dependent signalFunctional magnetic resonanceRepeated-measures analysisHemodynamic failureHemodynamic impairmentRevascularization proceduresIpsilateral hemisphereNeurological functionControl subjectsClinical consequencesBlood flowFunctional reorganizationSpontaneous resolution
2007
Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters
Egner T, Etkin A, Gale S, Hirsch J. Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters. Cerebral Cortex 2007, 18: 1475-1484. PMID: 17940084, DOI: 10.1093/cercor/bhm179.Peer-Reviewed Original ResearchConceptsTask-relevant stimuliEmotional distractersTask-irrelevant emotional stimuliAnterior cingulateSensory cortexTask-irrelevant stimuliLateral prefrontal cortexDorsal anterior cingulateFunctional magnetic resonanceRostral anterior cingulateCognitive controlConflict monitoringEmotional stimuliStimulus representationsAmygdalar responsesEmotional controlEnhanced processingResolve ConflictsEmotional conflictNeuroanatomical networksPrefrontal cortexDistractersResolution of conflictsBiasing mechanismHuman brainNeural Dynamics of Rejection Sensitivity
Kross E, Egner T, Ochsner K, Hirsch J, Downey G. Neural Dynamics of Rejection Sensitivity. Journal Of Cognitive Neuroscience 2007, 19: 945-956. PMID: 17536965, DOI: 10.1162/jocn.2007.19.6.945.Peer-Reviewed Original ResearchConceptsRejection sensitivityCognitive controlRS individualsDorsal frontal regionsFunctional magnetic resonanceThemes of rejectionRejection stimuliAffective stimuliEmotional appraisalEmotional processingNegative valenceIndividual differencesPrefrontal structuresNeural dynamicsDistress ratingsFrontal regionsRepresentational paintingsBrain regionsR participantsStimuliPositive imageDifferential recruitmentIndividual responsesParticipantsInterest level
2006
Functional Neuroimaging Applications for Assessment and Rehabilitation Planning in Patients With Disorders of Consciousness
Giacino JT, Hirsch J, Schiff N, Laureys S. Functional Neuroimaging Applications for Assessment and Rehabilitation Planning in Patients With Disorders of Consciousness. Archives Of Physical Medicine And Rehabilitation 2006, 87: 67-76. PMID: 17140882, DOI: 10.1016/j.apmr.2006.07.272.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessHigher-order association corticesStudy of patientsRestoration of functionPrimary cortical areasFunctional magnetic resonanceFunctional neuroimaging techniquesFunctional neuroimaging protocolsPotential clinical applicationsPathophysiologic mechanismsPattern of activationPatient characterizationPositron emission tomography activation studyDifferential diagnosisPrognostic assessmentDisconnection syndromeCortical areasAssociation cortexLarge-scale cortical networksPatientsNeuroimaging protocolVegetative stateNeuroimaging techniquesConscious stateCortical networksHemodynamic Impairment as a Stimulus for Functional Brain Reorganization
Marshall RS, Krakauer JW, Matejovsky T, Zarahn E, Barnes A, Lazar RM, Hirsch J. Hemodynamic Impairment as a Stimulus for Functional Brain Reorganization. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1256-1262. PMID: 16421509, DOI: 10.1038/sj.jcbfm.9600274.Peer-Reviewed Original ResearchConceptsVasomotor reactivityHemodynamic impairmentMotor-related activityControl subjectsFunctional reorganizationMotor regionsLevel-dependent signal intensityAbnormal cerebral hemodynamicsTypical motor activitiesLarge vessel occlusionSubgroup of patientsBlood oxygen level-dependent (BOLD) signal intensityContralateral motor areasFunctional brain reorganizationCarbon dioxide inhalationSimple motor taskFunctional magnetic resonanceAbnormal vasoreactivityTranscranial DopplerBrain reorganizationVessel occlusionCerebral hemodynamicsHand contralateralMotor areaFocal lesionsNeocortical Connectivity during Episodic Memory Formation
Summerfield C, Greene M, Wager T, Egner T, Hirsch J, Mangels J. Neocortical Connectivity during Episodic Memory Formation. PLOS Biology 2006, 4: e128. PMID: 16605307, PMCID: PMC1436028, DOI: 10.1371/journal.pbio.0040128.Peer-Reviewed Original ResearchConceptsEpisodic encodingPerceptual informationEpisodic memory tracesLeft dorsolateral prefrontal cortexNew episodic memoriesEpisodic memory formationFunctional magnetic resonanceDorsolateral prefrontal cortexExtrastriate visual cortexEpisodic memoryMemory tracesBrain mechanismsSensory representationsVisual stimuliPrefrontal cortexConnectivity analysisMemory formationVisual cortexNeocortical connectivityEncodingHemodynamic signalsCortexReliable predictorMemorySelective response
2005
Discordance between functional magnetic resonance imaging during silent speech tasks and intraoperative speech arrest.
Petrovich N, Holodny AI, Tabar V, Correa DD, Hirsch J, Gutin PH, Brennan CW. Discordance between functional magnetic resonance imaging during silent speech tasks and intraoperative speech arrest. Journal Of Neurosurgery 2005, 103: 267-74. PMID: 16175856, DOI: 10.3171/jns.2005.103.2.0267.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusSpeech taskPrecentral gyrusFMR imaging activationFunctional magnetic resonanceSpeech arrestFMR imaging studiesFMR imagingBehavioral resultsAwake cortical mappingFrontal gyrusLanguage functionHemispheric dominanceNeurosurgical planningMotor stripIntraoperative indicatorAwake craniotomyCortical mappingIntraoperative mappingHealthy volunteersImaging activityControl studyPredominant activationImaging studiesGyrusFunctional neuroimaging during altered states of consciousness: how and what do we measure?
Hirsch J. Functional neuroimaging during altered states of consciousness: how and what do we measure? Progress In Brain Research 2005, 150: 25-590. PMID: 16186013, DOI: 10.1016/s0079-6123(05)50003-7.Peer-Reviewed Original ResearchConceptsCognitive processesFunctional neuroimagingDisorders of consciousnessPassive stimulationLanguage-related tasksFunctional magnetic resonanceSpecific traumatic eventStudy of consciousnessFunctional brain activityAltered statesAffective systemsCognitive systemNeural processesTraumatic eventsNeurocognitive healthBrain activitySensory-motor functionParadigm selectionMotor systemVolitional tasksCortical functionExperimental manipulationTaskBrain injuryTemporal sequence
2004
Hypoperfusion without stroke alters motor activation in the opposite hemisphere
Krakauer JW, Radoeva PD, Zarahn E, Wydra J, Lazar RM, Hirsch J, Marshall RS. Hypoperfusion without stroke alters motor activation in the opposite hemisphere. Annals Of Neurology 2004, 56: 796-802. PMID: 15562431, DOI: 10.1002/ana.20286.Peer-Reviewed Original ResearchConceptsIpsilateral activationMiddle cerebral artery diseaseCerebral artery diseaseLarge vessel diseaseAge-matched controlsMotor-related areasNormal motor performanceFunctional magnetic resonanceHemodynamic compromiseVasomotor reactivityArtery diseaseHemispheric hypoperfusionCortical reorganizationInternal carotidHand contralateralPatientsMotor activationMotor tasksMotor performanceHypoperfusionHemispheric activationUnique activationDiseaseActivationMagnetic resonance