2024
11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 1-7. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutism
2020
Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, Green SA, Geschwind DH, Bookheimer SY, Dapretto M. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry 2020, 10: 82. PMID: 32127526, PMCID: PMC7054353, DOI: 10.1038/s41398-020-0750-9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeurotypical malesOXTR variantsBrain connectivityNeurobiological mechanismsPrefrontal cortexFunctional connectivityNetwork resting-state functional connectivityManifestation of ASDReward-related brain regionsResting-state functional connectivityBrain areasGreater functional connectivityPrefrontal brain areasFemale protective effectSubcortical brain areasSpectrum disorderMotor learningOXTR geneDiagnosis relateHigh OXTRBrain regionsGenetic riskSubcortical regionsSex differences
2015
Interactive social neuroscience to study autism spectrum disorder.
Rolison MJ, Naples AJ, McPartland JC. Interactive social neuroscience to study autism spectrum disorder. The Yale Journal Of Biology And Medicine 2015, 88: 17-24. PMID: 25745371, PMCID: PMC4345534.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAutism spectrum disorderSocial neuroscienceSpectrum disorderNeuropathology of ASDNeuroscience approachNeuroscience methodsNeural processesSocial difficultiesNeural mechanismsCommunication deficitsASD researchContext of interactionNeuroscience researchSocial interactionBrain regionsNeuroscienceDifficultiesLimited insightDisordersContextBrainDeficitsResearchIndividualsPeople
2012
Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies
Voos AC, Pelphrey KA, Tirrell J, Bolling DZ, Wyk B, Kaiser MD, McPartland JC, Volkmar FR, Ventola P. Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies. Journal Of Autism And Developmental Disorders 2012, 43: 1-10. PMID: 23104615, PMCID: PMC4999079, DOI: 10.1007/s10803-012-1683-9.Peer-Reviewed Original ResearchConceptsPivotal Response TreatmentAutism spectrum disorderSocial stimuliResponse treatmentFunctional magnetic resonance imagingYoung childrenNeural correlatesSocial motivationSocial skillsSocial perceptionNeural mechanismsNeural responsesBehavioral measuresSpectrum disorderSocial communicationBehavioral treatmentEye trackingNeural systemsAdaptive behaviorBrain regionsBaseline measuresStriking gainsStimuliChildrenPositive effect
2011
Recent advances in understanding the neural bases of autism spectrum disorder
McPartland JC, Coffman M, Pelphrey KA. Recent advances in understanding the neural bases of autism spectrum disorder. Current Opinion In Pediatrics 2011, 23: 628-632. PMID: 21970830, PMCID: PMC3413317, DOI: 10.1097/mop.0b013e32834cb9c9.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeural basisBrain systemsSpectrum disorderSocial information processingSocial brain regionsBehavioral performanceInformation processingAtypical activityBrain researchIndividual-specific profilesDevelopmental contextInitial evidenceMultimethod approachBrain regionsCompensatory areasBrain functionNeural dysfunctionHeterogeneous dysfunctionBehavioral phenotypingRecent researchAnomalous functionDisordersResearchProcessing
2010
Dissociable brain mechanisms for processing social exclusion and rule violation
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Mayes LC, Pelphrey KA. Dissociable brain mechanisms for processing social exclusion and rule violation. NeuroImage 2010, 54: 2462-2471. PMID: 20974272, PMCID: PMC3006641, DOI: 10.1016/j.neuroimage.2010.10.049.Peer-Reviewed Original ResearchMeSH KeywordsBrainCerebral CortexComputer GraphicsData Interpretation, StatisticalFemaleGames, ExperimentalHumansImage Processing, Computer-AssistedInterpersonal RelationsMagnetic Resonance ImagingMaleNerve NetNeural PathwaysPsychophysicsRejection, PsychologySocial EnvironmentSocial PerceptionYoung AdultConceptsVentral anterior cingulate cortexBrain regionsMagnetic resonance imaging studyDifferential functional connectivityResonance imaging studyFunctional magnetic resonance imaging studyAnterior cingulate cortexCingulate cortex activityMiddle temporal gyrusLateral parietal cortexVentrolateral prefrontal cortexCingulate cortexParietal cortexImaging studiesCortex activityFunctional connectivityTemporal gyrusPrefrontal cortexPosterior cingulate cortex activityActivation patternsCortexBrain mechanismsFunctional dissociationVirtual ball-tossing gameNeural systems