2017
Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease
Yang J, Zhang X, Yuan P, Yang J, Xu Y, Grutzendler J, Shao Y, Moore A, Ran C. Oxalate-curcumin–based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 12384-12389. PMID: 29109280, PMCID: PMC5703278, DOI: 10.1073/pnas.1706248114.Peer-Reviewed Original ResearchConceptsCerebral amyloid angiopathyAD brainAlzheimer's diseaseTwo-photon imagingNIRF imagingAmyloid-beta plaquesROS levelsIrreversible neurodegenerative disorderAD pathological conditionsAge-related increaseReactive oxygen species levelsAmyloid angiopathyBeta plaquesOxygen species levelsDrug treatmentHealthy brainNeurodegenerative disordersDiseaseOxidative stressHigh ROS levelsPathological conditionsReactive oxygen speciesBrainFluorescence imaging probeOxygen species
2015
Absolute two-photon excitation spectra of red and far-red fluorescent probes.
Velasco MG, Allgeyer ES, Yuan P, Grutzendler J, Bewersdorf J. Absolute two-photon excitation spectra of red and far-red fluorescent probes. Optics Letters 2015, 40: 4915-8. PMID: 26512482, DOI: 10.1364/ol.40.004915.Peer-Reviewed Original ResearchColorContrast MediaFluorescent DyesLightMaterials TestingMicroscopy, Fluorescence, MultiphotonScattering, RadiationSpectrometry, Fluorescence
2012
In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death
Harb R, Whiteus C, Freitas C, Grutzendler J. In Vivo Imaging of Cerebral Microvascular Plasticity from Birth to Death. Cerebrovascular And Brain Metabolism Reviews 2012, 33: 146-156. PMID: 23093067, PMCID: PMC3597363, DOI: 10.1038/jcbfm.2012.152.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsCerebral CortexEndothelium, VascularGreen Fluorescent ProteinsHypoxiaImmunohistochemistryMiceMice, Inbred StrainsMicroscopy, ConfocalMicroscopy, Fluorescence, MultiphotonMicrovesselsNeovascularization, PhysiologicConceptsVascular stabilityYoung adult miceFirst postnatal monthDegenerative neurological disordersVessel formationHypoxia-induced angiogenesisCerebral functionPostnatal monthAdult brainAdult miceIntact brainMicrovascular plasticityNeurological disordersFirst monthMicrovessel formationOlder adultsMetabolic challengesTwo-photon microscopyNew vesselsBaseline turnoverLong-term adaptive responsesIndividual microvesselsMiceVivo patternBrain
2011
Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition
Condello C, Schain A, Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Scientific Reports 2011, 1: 19. PMID: 22355538, PMCID: PMC3216507, DOI: 10.1038/srep00019.Peer-Reviewed Original ResearchMeSH KeywordsAgingAlzheimer DiseaseAnimalsBrainContrast MediaDisease Models, AnimalFluorescent DyesHumansMiceMice, TransgenicMicroscopy, Fluorescence, MultiphotonPlaque, AmyloidStaining and LabelingTissue DistributionConceptsPlaque burdenAmyloid depositionAlzheimer's diseaseAD mouse modelPlaque enlargementClinicopathological studyNeuritic dystrophyPathogenic rolePostmortem studiesAmyloid plaquesNew plaquesConsequent neurotoxicityMouse modelOld plaquesQuantitative confocal imagingCognitive statusPlaquesPlaque expansionOld animalsAmyloid-binding dyesNeurotoxicityDiseasePoor correlationBurdenCritical determinant