2007
Long-term two-photon transcranial imaging of synaptic structures in the living brain.
Grutzendler J, Gan WB. Long-term two-photon transcranial imaging of synaptic structures in the living brain. Cold Spring Harbor Protocols 2007, 2007: pdb.prot4766. PMID: 21357119, DOI: 10.1101/pdb.prot4766.Peer-Reviewed Original ResearchLiving brainNeurological disease modelsMouse brain areasIndividual dendritic spinesAxonal varicositiesFrontal cortexDendritic spinesBrain areasTherapeutic interventionsSynaptic structureFunctional changesNeuronal structuresTranscranial imagingTwo-photon microscopyDisease modelsBrainLiving mouseSensitive toolImaging approachMemory processesImagingSomatosensoryVaricositiesCortexMice
2006
Two-photon imaging of synaptic plasticity and pathology in the living mouse brain
Grutzendler J, Gan WB. Two-photon imaging of synaptic plasticity and pathology in the living mouse brain. Neurotherapeutics 2006, 3: 489-496. PMID: 17012063, PMCID: PMC3593400, DOI: 10.1016/j.nurx.2006.07.005.Peer-Reviewed Original ResearchConceptsTwo-photon microscopyMouse brainAcute brain injuryPostsynaptic dendritic spinesAdult mouse brainCerebral ischemiaSynaptic pathologyCerebrovascular diseaseBrain injuryMouse modelDendritic spinesAnimal modelsBrain cellsIntact brainTwo-photon imagingNeuronal connectionsSynaptic plasticityAlzheimer's diseaseNeuronal structuresDiseaseBrainStructural plasticityPathologyTechnical considerationsIschemia