Evaluation of (S)-[18F]OF-NB1 as a radioligand for Positron Emission Tomography imaging of GluN2B-NMDA

The purpose of this research study is to evaluate a new radioactive compound (or radiotracer), called (S)-[18F] OFNB, which attaches to the protein GluN2B-NMDA in the brain and body. The GluN2B-NMDA receptor plays a crucial role both in maintaining normal neural activity and in learning and memory processes. GluN2B-NMDA is a target of interest for the treatment of a range of neurological and neurodegenerative diseases, including stroke, Alzheimer’s Disease, Parkinson’s Disease and substance use disorders.