2025
Prospective comparison of the digestive tract resistome and microbiota in cattle raised in grass-fed versus grain-fed production systems
Kwon J, Tanner W, Kong Y, Wade M, Bitler C, Chiavegato M, Pettigrew M. Prospective comparison of the digestive tract resistome and microbiota in cattle raised in grass-fed versus grain-fed production systems. MSphere 2025, 10: e00738-24. PMID: 39950811, PMCID: PMC11934311, DOI: 10.1128/msphere.00738-24.Peer-Reviewed Original ResearchConceptsFarm management strategiesPost-weaningGrain dietGrass-fedFeed additivesPre-harvestProduction systemsResistance genesCattle production systemsPre-weaning periodFarm management practicesAbundance of antibiotic resistance genesBacterial communitiesFecal swab samplesPasture-raisedDiversity of ARGsGrain-fedBeef cattlePre-weaningMonths of ageGrowth promotionCattleBacterial community changesFood animalsFecal swabs
2022
Gastrointestinal Microbiome Disruption and Antibiotic-Associated Diarrhea in Children Receiving Antibiotic Therapy for Community-Acquired Pneumonia
Kwon J, Kong Y, Wade M, Williams DJ, Creech CB, Evans S, Walter EB, Martin JM, Gerber JS, Newland JG, Hofto ME, Staat MA, Chambers HF, Fowler VG, Huskins WC, Pettigrew M. Gastrointestinal Microbiome Disruption and Antibiotic-Associated Diarrhea in Children Receiving Antibiotic Therapy for Community-Acquired Pneumonia. The Journal Of Infectious Diseases 2022, 226: 1109-1119. PMID: 35249113, PMCID: PMC9492313, DOI: 10.1093/infdis/jiac082.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial Agentsbeta-LactamsChild, PreschoolCommunity-Acquired InfectionsDiarrheaGastrointestinal MicrobiomeHumansInfantPneumoniaConceptsAAD groupAntibiotic-associated diarrheaCommunity-acquired pneumoniaCommon side effectsStudy days 1Days of diarrheaPatient characteristicsAntibiotic therapyNineteen childrenStool samplesSide effectsDay 1Microbiome disruptionMicrobiota profilesGastrointestinal microbiotaMicrobiota characteristicsDiarrheaBacteroides speciesPneumoniaChildrenAntibioticsΒ-lactamsAADBaseline abundanceDysbiosis
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