Swapnil Chandrakant Devarkar
Associate Research ScientistCards
About
Research
Publications
2026
Dual site targeting of the bacterial 70S ribosome by tetracyclines
Devarkar S, Lomakin I, Wang J, Grada A, Bunick C. Dual site targeting of the bacterial 70S ribosome by tetracyclines. Nature Communications 2026, 17: 4452. PMID: 42156748, PMCID: PMC13186991, DOI: 10.1038/s41467-026-72788-9.Peer-Reviewed Original Research
2025
Visualizing the translation landscape in human cells at high resolution
Zheng W, Zhang Y, Wang J, Wang S, Chai P, Bailey E, Zhu C, Guo W, Devarkar S, Wu S, Lin J, Zhang K, Liu J, Lomakin I, Xiong Y. Visualizing the translation landscape in human cells at high resolution. Nature Communications 2025, 16: 10757. PMID: 41315256, PMCID: PMC12663405, DOI: 10.1038/s41467-025-65795-9.Peer-Reviewed Original ResearchDistinct Target Site of Lenacapavir in Immature HIV‑1 and Concurrent Binding with the Maturation Inhibitor Bevirimat
Wu C, Meuser M, Rey J, Meshkin H, Yang R, Devarkar S, Freniere C, Shi J, Aiken C, Perilla J, Xiong Y. Distinct Target Site of Lenacapavir in Immature HIV‑1 and Concurrent Binding with the Maturation Inhibitor Bevirimat. Journal Of The American Chemical Society 2025, 147: 42685-42700. PMID: 41198571, PMCID: PMC12900427, DOI: 10.1021/jacs.5c13735.Peer-Reviewed Original ResearchMechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells
Hollander K, Devarkar S, Tang S, Tiwari R, Ma S, Lee W, Denn E, Wang Q, Spasov K, Robbins J, Frey K, Jorgensen W, Xiong Y, Shan L, Anderson K. Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells. Npj Drug Discovery 2025, 2: 22. PMID: 40904837, PMCID: PMC12401731, DOI: 10.1038/s44386-025-00025-2.Peer-Reviewed Original ResearchNodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation
Naughton B, Devarkar S, Todorow V, Mallik S, Oxendine S, Junnarkar S, Ren Y, Berro J, Kirstein J, Xiong Y, Schlieker C. Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation. Journal Of Cell Biology 2025, 224: e202505010. PMID: 40663102, PMCID: PMC12262048, DOI: 10.1083/jcb.202505010.Peer-Reviewed Original ResearchStructural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase
Devarkar S, Budding C, Pathirage C, Kavoor A, Herbert C, Limbach P, Musier-Forsyth K, Xiong Y. Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase. Nucleic Acids Research 2025, 53: gkaf114. PMID: 40036503, PMCID: PMC11878792, DOI: 10.1093/nar/gkaf114.Peer-Reviewed Original Research
2024
Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research
Lomakin I, Devarkar S, Freniere C, Bunick C. Practical Guide for Implementing Cryogenic Electron Microscopy Structure Determination in Dermatology Research. Journal Of Investigative Dermatology 2024, 145: 22-31. PMID: 39601740, PMCID: PMC11748023, DOI: 10.1016/j.jid.2024.10.594.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMechanistic Basis for the Translation Inhibition of Cutibacterium acnes by Clindamycin
Lomakin I, Devarkar S, Grada A, Bunick C. Mechanistic Basis for the Translation Inhibition of Cutibacterium acnes by Clindamycin. Journal Of Investigative Dermatology 2024, 144: 2553-2561.e3. PMID: 39122144, DOI: 10.1016/j.jid.2024.07.013.Peer-Reviewed Original Research
2023
Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses
Devarkar S, Vetick M, Balaji S, Lomakin I, Yang L, Jin D, Gilbert W, Chen S, Xiong Y. Structural basis for translation inhibition by MERS-CoV Nsp1 reveals a conserved mechanism for betacoronaviruses. Cell Reports 2023, 42: 113156. PMID: 37733586, PMCID: PMC12447786, DOI: 10.1016/j.celrep.2023.113156.Peer-Reviewed Original ResearchGroup II intron splicing mechanisms – ribozymes and retrotransposons
Xu L, Chung K, Liu T, Chai P, Peng J, Devarkar S, Pyle A. Group II intron splicing mechanisms – ribozymes and retrotransposons. Acta Crystallographica Section A: Foundations And Advances 2023, 79: a260-a260. DOI: 10.1107/s2053273323097395.Peer-Reviewed Original Research
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