2025
Ultrasound Guidance for Botulinum Toxin Injection of Muscles Innervated by the Facial Nerve: A Systematic Review of Anatomical Precision, Safety, and Outcomes
Chowdhury R, Schiff B, Lee Y, Mohan S. Ultrasound Guidance for Botulinum Toxin Injection of Muscles Innervated by the Facial Nerve: A Systematic Review of Anatomical Precision, Safety, and Outcomes. Aesthetic Surgery Journal 2025, sjaf175. PMID: 40971765, DOI: 10.1093/asj/sjaf175.Peer-Reviewed Original ResearchUltrasound guidanceBotulinum toxin injectionSystematic reviewLandmark-based techniqueAdverse eventsPatient satisfactionPatient-reported measuresHigh-resolution ultrasoundOff-target deliveryBotulinum toxin type AInjection of muscleRisk of biasCadaveric trialsRandomized Controlled TrialsToxin type ARhytid reductionFacial nerveFacial synkinesisClinical efficacyClinical outcomesProspective cohortClinical studiesBoNT-AFacial symmetryInjection accuracy
2024
Applications of artificial intelligence in facial plastic and reconstructive surgery: a systematic review
Souza S, Bhethanabotla R, Mohan S. Applications of artificial intelligence in facial plastic and reconstructive surgery: a systematic review. Current Opinion In Otolaryngology & Head & Neck Surgery 2024, 32: 222-233. PMID: 38695544, DOI: 10.1097/moo.0000000000000975.Peer-Reviewed Original ResearchConceptsFacial plastic surgeryArtificial intelligence applicationsArtificial intelligencePlastic surgeryIntelligence applicationsSystematic reviewArtificial intelligence functionsFacial palsy gradeFacial profileApplication of artificial intelligenceSurgeon awarenessReconstructive surgeryArtificial intelligence toolsFacial plasticPatient evaluationArtificial intelligence modelsLandmark detectionSurgeryModel trainingSurgeonsIntelligence toolsDiverse datasetsIntelligence modelsIntelligent functionsIntelligence
2023
Utility of an Artificial Intelligence Language Model for Post-Operative Patient Instructions Following Facial Trauma
Mohan S, Souza S, Fakurnejad S, Knott P. Utility of an Artificial Intelligence Language Model for Post-Operative Patient Instructions Following Facial Trauma. Craniomaxillofacial Trauma & Reconstruction 2023, 17: 291-294. PMID: 39634572, PMCID: PMC11613249, DOI: 10.1177/19433875231222803.Peer-Reviewed Original ResearchElectronic medical recordsPost-operative instructionsElectronic medical record templatesGoogle search enginePatient Education Materials Assessment ToolFacial traumaTrauma proceduresPEMAT-PProcedure-specific scoresUnderstanding scoresAssessment toolPatient instructionsMedical recordsSearch enginesAction scoresScoresTailored instructionSacral metastases in a patient with BRAF V600E+ papillary thyroid carcinoma
Bhethanabotla R, Mohan S, Lin D, Shah P. Sacral metastases in a patient with BRAF V600E+ papillary thyroid carcinoma. Journal Of Surgical Case Reports 2023, 2023: rjad585. PMID: 38026745, PMCID: PMC10640671, DOI: 10.1093/jscr/rjad585.Peer-Reviewed Original ResearchPapillary thyroid carcinomaSynchronous distant metastasesMagnetic resonance imagingDistant metastasisThyroid carcinomaHip painComputed tomographyMetastatic papillary thyroid carcinomaUltrasound-guided fine-needle aspirationSupraclavicular neck massLymph node dissectionLeft hip painFine-needle aspirationWeeks post-operativelySacral metastasesNeck massNode dissectionOsseous metastasesTotal thyroidectomySacral massNeedle aspirationPost-operativelyBony lesionsMetastasisMolecular testingNoncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis
Tenney A, Di Gioia S, Webb B, Chan W, de Boer E, Garnai S, Barry B, Ray T, Kosicki M, Robson C, Zhang Z, Collins T, Gelber A, Pratt B, Fujiwara Y, Varshney A, Lek M, Warburton P, Van Ryzin C, Lehky T, Zalewski C, King K, Brewer C, Thurm A, Snow J, Facio F, Narisu N, Bonnycastle L, Swift A, Chines P, Bell J, Mohan S, Whitman M, Staffieri S, Elder J, Demer J, Torres A, Rachid E, Al-Haddad C, Boustany R, Mackey D, Brady A, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg G, Raskin S, Sato M, Orkin S, Parker S, Hadlock T, Vissers L, van Bokhoven H, Jabs E, Collins F, Pennacchio L, Manoli I, Engle E. Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis. Nature Genetics 2023, 55: 1149-1163. PMID: 37386251, PMCID: PMC10335940, DOI: 10.1038/s41588-023-01424-9.Peer-Reviewed Original ResearchConceptsSingle-nucleotide variantsGATA2 expressionHereditary congenital facial paresisBranchial motor neuronsLoss of GATA3Temporal gene regulationRare Mendelian diseasesChromosome 3q21-q22Autosomal dominant disorderSilencing in vitroNoncoding variationNoncoding variantsFacial paresisMendelian diseasesGene regulationRegulatory regionsHeterozygous duplicationDominant disorderMouse modelReporter expressionType 1Efferent neuronsMotor neuronsGATA2In vivo
2022
Super-resolved fluorescence imaging of peripheral nerve
Hernández I, Mohan S, Minderler S, Jowett N. Super-resolved fluorescence imaging of peripheral nerve. Scientific Reports 2022, 12: 12450. PMID: 35864187, PMCID: PMC9304405, DOI: 10.1038/s41598-022-16769-0.Peer-Reviewed Original ResearchConceptsSuper-resolution microscopySuper-resolution imagingNanoscale resolutionSuper-resolution imaging techniquesEmission depletion (STED) microscopyNanoscale cellular structuresStructured illumination microscopyElectron microscopyVisible lightDiffraction limited resolutionDepletion microscopyMicroscopyFluorescence imagingNon-toxic meansIllumination microscopyBiomedical sciencesFluorescent dyeBrightfield microscopyFluorescent objectsSample preparationFluctuation microscopyAutomated stain-free histomorphometry of peripheral nerve by contrast-enhancing techniques and artificial intelligence
Coto Hernández I, Mohan S, Jowett N. Automated stain-free histomorphometry of peripheral nerve by contrast-enhancing techniques and artificial intelligence. Journal Of Neuroscience Methods 2022, 375: 109598. PMID: 35436515, DOI: 10.1016/j.jneumeth.2022.109598.Peer-Reviewed Original ResearchConceptsDeep learning algorithmsDeep learningArtificial intelligenceMachine learningLearning algorithmImage processingImage reconstructionExisting methodsSegmentationPhase contrast imagesLearningContrast imagesImagesIntelligenceAlgorithmEmbeddingBrightfield microscopyTechniqueTransmission modalityProcessingApplications
2020
Considerations in Management of Acute Otitis Media in the COVID-19 Era
Mohan S, Workman A, Barshak M, Welling D, Abdul-Aziz D. Considerations in Management of Acute Otitis Media in the COVID-19 Era. Annals Of Otology Rhinology & Laryngology 2020, 130: 520-527. PMID: 32911957, DOI: 10.1177/0003489420958443.Peer-Reviewed Original ResearchConceptsMiddle ear fluidAcute otitis mediaComplicated acute otitis mediaEar fluidOtitis mediaSARS-CoV-2 infectionSARS-CoV-2Management of Acute Otitis MediaFacial paralysisPCR of nasopharyngeal swabClinical management of patientsPositive viral PCRTreated with myringotomyManagement of patientsBlue light filterCadaveric temporal bonesOtologic findingsSystemic antibioticsEar diseaseNegative PCRAcute infectionClinical managementOtologic proceduresProlonged close contactNasopharyngeal swabsLabel‐free histomorphometry of peripheral nerve by stimulated Raman spectroscopy
Hernández I, Yang W, Mohan S, Jowett N. Label‐free histomorphometry of peripheral nerve by stimulated Raman spectroscopy. Muscle & Nerve 2020, 62: 137-142. PMID: 32304246, DOI: 10.1002/mus.26895.Peer-Reviewed Original ResearchMotor and sensory rehabilitation of the lower lip
Mohan S, Jowett N. Motor and sensory rehabilitation of the lower lip. Operative Techniques In Otolaryngology-Head And Neck Surgery 2020, 31: 45-54. DOI: 10.1016/j.otot.2019.12.010.Peer-Reviewed Original ResearchToward an Automatic System for Computer-Aided Assessment in Facial Palsy
Guarin D, Yunusova Y, Taati B, Dusseldorp J, Mohan S, Tavares J, van Veen M, Fortier E, Hadlock T, Jowett N. Toward an Automatic System for Computer-Aided Assessment in Facial Palsy. Facial Plastic Surgery & Aesthetic Medicine 2020, 22: 42-49. PMID: 32053425, PMCID: PMC7362997, DOI: 10.1089/fpsam.2019.29000.gua.Peer-Reviewed Original ResearchConceptsFacial landmark localizationLandmark localizationMachine learningML algorithmsFacial landmarksAutomatic systemComputer-aided diagnosis systemLocalization accuracyGraphical user interfaceCustom graphical user interfaceLandmark localization accuracyComputer-Aided AssessmentPoor localization accuracyUser interfaceDetection modelMore imagesDiagnosis systemML modelsAvailable algorithmsManual markingNovel ML algorithmsNovel ML modelsLarge databaseAlgorithm accuracyLocalization model
2019
Implantable wireless device for study of entrapment neuropathy
Malka R, Guarin D, Mohan S, Hernández I, Gorelik P, Mazor O, Hadlock T, Jowett N. Implantable wireless device for study of entrapment neuropathy. Journal Of Neuroscience Methods 2019, 329: 108461. PMID: 31626845, PMCID: PMC7325518, DOI: 10.1016/j.jneumeth.2019.108461.Peer-Reviewed Original ResearchConceptsAnimal modelsFunctional lossNeural dysfunctionGrade V injuriesFacial nerve functionSmall animal modelsPartial functional lossComplete functional lossWhisker displacementSurgical decompressionEntrapment syndromeDecompression surgeryNerve functionBell's palsyNerve damageFunctional recoveryGrade IIIFacial nervePeripheral nervesCompartment pressuresMurine modelDisease processInsufficient evidenceLive animal modelsOptimal timingAssociations between national financial trends and facial plastic surgery procedural volume
Gadkaree S, McCarty J, Weitzman R, Derakhshan A, Mohan S, Bergmark R, Shaye D. Associations between national financial trends and facial plastic surgery procedural volume. The Laryngoscope 2019, 130: 632-636. PMID: 31603542, DOI: 10.1002/lary.28311.Peer-Reviewed Original ResearchConceptsAmerican Society of Plastic SurgeonsSurgery proceduresCosmetic plastic surgery proceduresProcedure ratesRate of rhinoplastyRetrospective cohort studyAnnual procedure ratesCosmetic surgeryPlastic surgery casesPlastic surgery proceduresReconstructive surgery proceduresSurgery casesMultivariate regression modelCohort studyReconstructive surgerySurgeryReconstruction casesFacial plasticKolmogorov–Smirnov “goodness of fit” testPlastic surgeonsProcedure volumeProcedural trendsGross domestic productOtoplastyRhinoplastyStain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy
Mohan S, Hernández I, Selig M, Shibata S, Jowett N. Stain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy. Journal Of Neuropathology & Experimental Neurology 2019, 78: 1178-1180. PMID: 31642916, PMCID: PMC7967843, DOI: 10.1093/jnen/nlz099.Peer-Reviewed Original ResearchHealth Utility Values as an Outcome Measure in Patients Undergoing Functional Septorhinoplasty
Gadkaree S, Fuller J, Justicz N, Weitzman R, Derakhshan A, Mohan S, Lindsay R. Health Utility Values as an Outcome Measure in Patients Undergoing Functional Septorhinoplasty. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 381-386. PMID: 31120515, PMCID: PMC6547223, DOI: 10.1001/jamafacial.2019.0234.Peer-Reviewed Original ResearchConceptsHealth utility valuesEQ-5D scoresOverall healthNasal obstructionMeasure health utility valuesFunctional septorhinoplastyEuroQol-5 DimensionsPopulation-based dataImprove overall healthPostoperative EQ-5D scoresEQ-5D questionnaireProspective cohort studyOutcome of septorhinoplastyChronic conditionsEQ-5D surveyEQ-5DUS populationChronic diseasesOutcome measuresCohort studyUtility valuesHealthSinus surgeryNasal surgeryFemale sexA Comparative Health Utility Value Analysis of Outcomes for Patients Following Septorhinoplasty With Previous Nasal Surgery
Gadkaree S, Fuller J, Justicz N, Derakhshan A, Mohan S, Yu P, Lindsay R. A Comparative Health Utility Value Analysis of Outcomes for Patients Following Septorhinoplasty With Previous Nasal Surgery. Facial Plastic Surgery & Aesthetic Medicine 2019, 21: 402-406. PMID: 31194223, PMCID: PMC6567843, DOI: 10.1001/jamafacial.2019.0176.Peer-Reviewed Original ResearchConceptsHealth utility valuesProspective cohort studyNasal surgerySingle-institution prospective cohort studyCohort studyFunctional rhinoplastyPredictors of outcomeHealth utilization outcomesEQ-5D scoresEQ-5D questionnaireAlar rim graftsAnalysis of outcomesCost-utility analysisSleep apneaNasal obstructionSurgical historyUtilization outcomesPrimary rhinoplastySurgical proceduresHealth statusMultivariate analysisSurgeryRim graftsOverall healthSpreader graftsAn Anatomic Variant of the Ansa Cervicalis Precluding Its Use as a Donor Nerve
Zhu A, Mohan S, Richmon J, Jowett N. An Anatomic Variant of the Ansa Cervicalis Precluding Its Use as a Donor Nerve. Annals Of Otology Rhinology & Laryngology 2019, 129: 78-81. PMID: 31510759, DOI: 10.1177/0003489419875975.Peer-Reviewed Original ResearchConceptsAnsa cervicalisAnatomic variantsVagus nerveParotid adenoid cystic carcinomaLeft vocal fold palsyCranial nerve repairFacial nerve resectionIpsilateral hypoglossal nerveRelevant anatomic variantsVocal fold palsyAdenoid cystic carcinomaInterposition repairDonor nerveNerve resectionSural nerveHypoglossal nerveInadvertent injuryNerve epineuriumCystic carcinomaGraft harvestNerve repairApparent morbidityNerveMuscle contractionCervicalis
2018
Outcome Tracking in Facial Palsy
Dusseldorp J, van Veen M, Mohan S, Hadlock T. Outcome Tracking in Facial Palsy. Otolaryngologic Clinics Of North America 2018, 51: 1033-1050. PMID: 30172554, DOI: 10.1016/j.otc.2018.07.003.Peer-Reviewed Original ResearchFluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model
Mohan S, Hernández I, Wang W, Yin K, Sundback C, Wegst U, Jowett N. Fluorescent Reporter Mice for Nerve Guidance Conduit Assessment: A High‐Throughput in vivo Model. The Laryngoscope 2018, 128: e386-e392. PMID: 30098047, DOI: 10.1002/lary.27439.Peer-Reviewed Original ResearchConceptsHigh-throughput platformConduit performanceTissue processing stepsRobust axonal sproutingSciatic nerve transectionHigh throughputCryosection techniqueFluorescent reporter miceVivo mammalian modelsInterposition repairAxonal sproutingNerve transectionIsoflurane anesthesiaPeripheral neuronsAxonal ingrowthProcedure timeReporter miceNerve regenerationTransgenic miceVivo modelMiceMicroscopyVivo platformFluorescent proteinFluorescent microscopyLong-Term Outcomes of Free Gracilis Muscle Transfer for Smile Reanimation in Children
Greene J, Tavares J, Mohan S, Jowett N, Hadlock T. Long-Term Outcomes of Free Gracilis Muscle Transfer for Smile Reanimation in Children. The Journal Of Pediatrics 2018, 202: 279-284.e2. PMID: 30054167, DOI: 10.1016/j.jpeds.2018.06.043.Peer-Reviewed Original ResearchConceptsFree gracilis muscle transferFacial palsyGracilis muscle transferSmile excursionQuality of lifeMuscle transferPostoperative photographySmile reanimationFacial Clinimetric Evaluation (FaCE) surveyPatient-based instrumentLong-term outcomesCohort of childrenFacial nerve centerFacial symmetryPediatric patientsPostoperative qualityLife scoresTerm outcomesRetrospective analysisMassachusetts EyePalsySignificant improvementFacial impairmentPatientsFacial asymmetry
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