Sowmya Sharma, MD
Assistant ProfessorCards
About
Research
Publications
2025
Characterizing Healthcare Disparities, Utilization, and Trends of Inflammatory Bowel Disease in Transgender and Nonbinary Patients: A Population-Based Study
Suchan A, Chaaban L, Kobeissi L, Hassan B, Liang F, Sharma S, Melia J. Characterizing Healthcare Disparities, Utilization, and Trends of Inflammatory Bowel Disease in Transgender and Nonbinary Patients: A Population-Based Study. Inflammatory Bowel Diseases 2025, 32: 643-649. PMID: 41400636, DOI: 10.1093/ibd/izaf266.Peer-Reviewed Original ResearchIncidence of Anti-Drug Antibody Development in Older Adults with Inflammatory Bowel Disease Treated with Tumor Necrosis Factor Alpha Inhibitors: A Large Multicenter Cohort Study
Frost S, Ambastha C, Patel D, Roney A, Greb A, Rangel-Garcia M, Sauk J, Chang C, Park S, Parian A, Suchan A, Moughames E, Krishna M, Chowdhury R, Sharma S, Maas L, Ho A, Lazarev M, Limketkai B, Limsui D, Keyashian K. Incidence of Anti-Drug Antibody Development in Older Adults with Inflammatory Bowel Disease Treated with Tumor Necrosis Factor Alpha Inhibitors: A Large Multicenter Cohort Study. Inflammatory Bowel Diseases 2025, 31: 3356-3362. PMID: 40971840, DOI: 10.1093/ibd/izaf170.Peer-Reviewed Original Researchtumor necrosis factor inhibitorsanti-drug antibodiestherapeutic drug monitoringanti-drug antibody developmentproactive therapeutic drug monitoringinflammatory bowel diseasedrug monitoringrisks of anti-drug antibodiescohort studyincidence of anti-drug antibodiestumor necrosis factor-alpha inhibitorslongitudinal riskmulticenter retrospective cohort studysubtherapeutic trough levelsassociation of potential risk factorsmulticenter cohort studyyoung adultsretrospective cohort studyCox regression methodroutine drug monitoringpotential risk factorsdose escalationtrough levelsfactor inhibitorsKaplan-MeierRetrospective Cohort Study on the Predictive Value of Primary Non-response to Initial Biologic for Future Biologic Use in Patients with Inflammatory Bowel Disease
Krishna M, Spartz E, Maas L, Cusumano V, Sharma S, Limketkai B, Parian A. Retrospective Cohort Study on the Predictive Value of Primary Non-response to Initial Biologic for Future Biologic Use in Patients with Inflammatory Bowel Disease. Digestive Diseases And Sciences 2025, 70: 746-753. PMID: 39755922, DOI: 10.1007/s10620-024-08816-9.Peer-Reviewed Original ResearchConceptssecondary loss of responseprimary non-responseinflammatory bowel diseaseloss of responsemulticenter retrospective chart review studyarmamentarium of medical therapiesCrohn's diseasebowel diseasenon-responsepredictive valueretrospective chart review studycessation of drugweeks of treatmentretrospective cohort studychart review studytreat inflammatory bowel diseaseadverse side effectsbiologic therapysymptomatic improvementmedical therapyrate of responsetreatment optionsunivariate analysismedication switchIBD-unclassified
2024
Primary healthcare provider-perceived barriers to implementing an evidence-based pathway for undifferentiated lower gastrointestinal tract symptoms: A qualitative inquiry
Sharma S, Stewart M, Mathias H, Novak K, Van Zanten S, Heisler C, Richard S, Neil E, Burge F, Smith A, Peltekian K, Patel S, Jones J. Primary healthcare provider-perceived barriers to implementing an evidence-based pathway for undifferentiated lower gastrointestinal tract symptoms: A qualitative inquiry. PLOS ONE 2024, 19: e0313201. PMID: 39739887, PMCID: PMC11687702, DOI: 10.1371/journal.pone.0313201.Peer-Reviewed Original Research
2023
PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease
Ismail M, Peters D, Rowe S, Salavati A, Sharma S, Anders R, Pomper M, Slusher B, Selaru F. PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease. Clinical And Experimental Gastroenterology 2023, 16: 237-247. PMID: 38090679, PMCID: PMC10714977, DOI: 10.2147/ceg.s404009.Peer-Reviewed Original Researchprostate-specific membrane antigeninflammatory bowel diseaseactive inflammationPositron Emission Tomography/Computed Tomographybowel diseaseEmission Tomography/Computed Tomographyinflammatory bowel disease patientsmanagement of inflammatory bowel diseasemucosa of patientsnon-invasive visualizationimaging agentssegment of bowelTomography/Computed Tomographymembrane antigenactive diseasedisease activityclinical valueimaging biomarkersnoninvasive meansinflammationpatientsdiseaseTime for a Gut Check: A Qualitative Study of Proposed Interventions to Address Gender Inequality in Gastroenterology
Sharma S, Mathias H, Jones E, Heisler C, Rohatinsky N, Novak K, Leung Y, Fowler S, Kaczur M, Targownik L, Jones J. Time for a Gut Check: A Qualitative Study of Proposed Interventions to Address Gender Inequality in Gastroenterology. Journal Of The Canadian Association Of Gastroenterology 2023, 6: 155-161. PMID: 37811530, PMCID: PMC10558195, DOI: 10.1093/jcag/gwad022.Peer-Reviewed Original ResearchAntibody Kinetics after Three Doses of SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease
Tsipotis E, Maremanda A, Zeiser L, Connolly C, Sharma S, Dudley-Brown S, Frey S, Lazarev M, Melia J, Parian A, Segev D, Truta B, Yu H, Werbel W, Selaru F. Antibody Kinetics after Three Doses of SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease. Medicina 2023, 59: 1487. PMID: 37629777, PMCID: PMC10456461, DOI: 10.3390/medicina59081487.Peer-Reviewed Original ResearchSuperior Efficacy of Infliximab Versus Adalimumab for First-Line Treatment of Crohn’s Perianal Fistulae
Maas L, Gao R, Cusumano V, Spartz E, Chowdhury R, Krishna M, Lazarev M, Melia J, Selaru F, Sharma S, Limketkai B, Parian A. Superior Efficacy of Infliximab Versus Adalimumab for First-Line Treatment of Crohn’s Perianal Fistulae. Digestive Diseases And Sciences 2023, 68: 3994-4000. PMID: 37540392, DOI: 10.1007/s10620-023-08060-7.Peer-Reviewed Original ResearchConceptsadalimumab groupinfliximab groupclinical responseperianal fistulastumor necrosis factor inhibitorsconcomitant immunomodulator therapyhigher treatment persistenceefficacy of infliximabfirst-line treatmentKaplan Meier methodmethodsA retrospective studyassociated with higher ratesCrohn's perianal fistulasdose escalationconcomitant immunomodulatorsfistula responseimmunomodulating therapyfactor inhibitorsMeier methodtreatment persistencesecondary endpointsclinical improvementinitial treatmentretrospective studysuperior efficacy
2022
Perceived Barriers to Professional Equality Among Women in Gastroenterology
Jones E, Sharma S, Heisler C, Rohatinsky N, Novak K, Leung Y, Fowler S, Kaczur M, Jones J. Perceived Barriers to Professional Equality Among Women in Gastroenterology. Journal Of The Canadian Association Of Gastroenterology 2022, 5: 226-233. PMID: 36196275, PMCID: PMC9527661, DOI: 10.1093/jcag/gwac023.Peer-Reviewed Original Research
2021
Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home
Tsien C, Tan H, Sharma S, Palaniyappan N, Wijayasiri P, Leung K, Hayre J, Mowlem E, Kang R, Eddowes P, Wilkes E, Venkatachalapathy S, Guha I, Antonova L, Cheung A, Griffiths W, Butler A, Ryder S, James M, Aithal G, Aravinthan A. Long-term outcomes of liver transplant recipients followed up in non-transplant centres: Care closer to home. Clinical Medicine 2021, 21: e32-e38. PMID: 33479081, PMCID: PMC7850197, DOI: 10.7861/clinmed.2020-0609.Peer-Reviewed Original ResearchConceptslong-term clinical outcomesliver transplant recipientslong-term outcomestransplant recipientsliver transplantationcumulative incidencedeath-censored graft survivalpost-transplant follow-upend-stage renal diseasepatient survival ratesmajor cardiovascular eventsmodel of healthcaregraft survivalpatient survivaladult patientsclinical outcomesretrospective analysiscardiovascular eventsFollow-uprenal disease
Clinical Care
Overview
Clinical Specialties
Gastroenterology
Board Certifications
Internal Medicine
- Certification Organization
- ABIM
- Original Certification Date
- 2025
Gastroenterology
- Certification Organization
- Royal College of Physicians & Surgeons of CANADA
- Original Certification Date
- 2022
Internal Medicine
- Certification Organization
- Royal College of Physicians & Surgeons of CANADA
- Original Certification Date
- 2021
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Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, Connecticut 06520-8019
United States