Robert Ostroff, MD
Medical Director Mood Disorders Unit Yale Psychiatric hospitalAbout
Research
Publications
2026
Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol
Wilkinson S, Prashad S, Dalthorp R, Harding L, Kitay B, Parikh S, Dziura J, Clayton A, Fram G, Lepoutre V, Brown J, Ostroff R, Sanacora G. Non-inferiority, comparative effectiveness study of intravenous ketamine v. intranasal esketamine for treatment-resistant depression: The EQUIVALENCE trial protocol. Contemporary Clinical Trials 2026, 164: 108273. PMID: 41780747, DOI: 10.1016/j.cct.2026.108273.Peer-Reviewed Original Research
2024
Safe Delivery of Electroconvulsive Therapy in a Patient With Obstructive Sleep Apnea and a Hypoglossal Nerve Stimulator
Hughes M, Cohen T, Ostroff R, Katz R. Safe Delivery of Electroconvulsive Therapy in a Patient With Obstructive Sleep Apnea and a Hypoglossal Nerve Stimulator. Journal Of Ect 2024, 41: e24-e25. PMID: 39589131, DOI: 10.1097/yct.0000000000001089.Peer-Reviewed Case Reports and Technical NotesBlood pressure changes during ketamine infusion for the treatment of depression
Ansari M, Pittman B, Tylee D, Ostroff R, Wilkinson S, Nikayin S. Blood pressure changes during ketamine infusion for the treatment of depression. General Hospital Psychiatry 2024, 90: 62-67. PMID: 38991311, DOI: 10.1016/j.genhosppsych.2024.07.001.Peer-Reviewed Original ResearchKetamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Jha M, Wilkinson S, Krishnan K, Collins K, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew S, Anand A. Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression. JAMA Network Open 2024, 7: e2417786. PMID: 38916891, PMCID: PMC11200139, DOI: 10.1001/jamanetworkopen.2024.17786.Peer-Reviewed Original Research
2023
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
Iqbal S, Malone D, Wolski K, Anand A, Mathew S, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Chang L, Collins K, Costi S, Jha M, Krishnan K, Nikayin S, Ostroff R, Reti I, Wilkinson S, Hu B, Barnett B, Nissen S. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. The New England Journal Of Medicine 2023, 388: 2315-2325. PMID: 37224232, DOI: 10.1056/nejmoa2302399.Peer-Reviewed Original Research
2020
A strategy for treating pseudobulbar affect
Morrone A, Morrow G, Ostroff R. A strategy for treating pseudobulbar affect. Neurology Psychiatry And Brain Research 2020, 37: 52. DOI: 10.1016/j.npbr.2020.06.002.Commentaries, Editorials and Letters
2018
The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion
Kitay B, Katz R, Wilkinson S, Ostroff R. The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion. Journal Of Ect 2018, 1. DOI: 10.1097/00124509-900000000-99225.Peer-Reviewed Case Reports and Technical NotesErratum to: Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.Commentaries, Editorials and LettersThe Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders
Ostroff R, Katz R. The Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders. Current Treatment Options In Psychiatry 2018, 5: 228-241. DOI: 10.1007/s40501-018-0144-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2017
Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson S, Ostroff R, Katz R, Krystal J. Ketamine: A Promising Rapid-Acting Antidepressant. 2017, 223-239. DOI: 10.1007/978-981-10-6577-4_16.Chapters
News
News
- September 11, 2026
Eleven Faculty Nominated for YSM Teaching Awards
- March 09, 2026Source: NBC Connecticut (with Dr. Robert Ostroff)
Feeling SAD? How To Beat the Winter Blues
- January 08, 2026Source: WFSB-TV Channel 3
Health Experts Say Dry January Can Bring Measurable Benefits in Just 31 Days
- December 01, 2025
The Rise of Interventional Psychiatry