Richard Formica, MD
Professor of Medicine (Nephrology) and Professor of Surgery (Transplant)Cards
About
Research
Publications
2024
The role of C4d and donor specific antibodies in face and hand transplantation—a systematic review
Huelsboemer L, Moscarelli J, Dony A, Boroumand S, Kochen A, Knoedler L, Yu C, Hauc S, Stögner V, Formica R, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The role of C4d and donor specific antibodies in face and hand transplantation—a systematic review. Frontiers In Transplantation 2024, 3: 1442006. PMID: 39291278, PMCID: PMC11405992, DOI: 10.3389/frtra.2024.1442006.Peer-Reviewed Original ResearchDonor-specific antibodiesSerum donor-specific antibodiesAntibody-mediated rejectionHigher rejection gradesVascularized composite allotransplantationC4d depositionRejection gradeCellular rejectionRejection episodesSpecific antibodiesDonor-specific antibody statusManagement of antibody-mediated rejectionFace transplantationAcute cellular rejectionAcute rejection episodesAssociated with high gradeTime of biopsyAntibody mediated rejectionFisher's exact testMann-Whitney U testSystematic review of electronic databasesMechanisms of rejectionSystematic reviewReview of electronic databasesC4d stainingD111. Ten year Follow up after Face Transplantation
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. D111. Ten year Follow up after Face Transplantation. Plastic & Reconstructive Surgery Global Open 2024, 12: 120-121. PMCID: PMC11340540, DOI: 10.1097/01.gox.0001018916.83172.5e.Peer-Reviewed Original Research12. Functional Long-Term Outcome Of Eight Face Transplant Patients - A Single Center Study
Huelsboemer L, Stoegner V, Boroumand S, Parikh N, Hosseini H, Perry B, Formica R, Kauke-Navarro M, Pomahac B. 12. Functional Long-Term Outcome Of Eight Face Transplant Patients - A Single Center Study. Plastic & Reconstructive Surgery Global Open 2024, 12: 8-9. PMCID: PMC11041197, DOI: 10.1097/01.gox.0001015140.10439.0d.Peer-Reviewed Original ResearchThe gratitude paradox
Chisholm‐Burns M, Formica R. The gratitude paradox. Journal Of Internal Medicine 2024, 295: 712-714. PMID: 38575552, DOI: 10.1111/joim.13788.Peer-Reviewed Original ResearchImmunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failureUse of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians
Wiseman A, Alhamad T, Alloway R, Concepcion B, Cooper M, Formica R, Klein C, Kumar V, Leca N, Shihab F, Taber D, Mulnick S, Bushnell D, Hadi M, Bunnapradist S. Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians. Annals Of Transplantation 2024, 29: e943498-1-e943498-13. PMID: 38526543, PMCID: PMC10944009, DOI: 10.12659/aot.943498.Peer-Reviewed Original ResearchConceptsLCP-tacrolimusImmediate-release tacrolimusKidney transplantationFirst-line optionKidney transplant recipientsRandomized clinical trialsDe novo settingTacrolimus formulationReview available dataEvidence-based recommendationsTrough levelsOnce-dailyTransplant recipientsClinical decision-makingOptimal doseClinical trialsExpert cliniciansConsensus statementTransplant expertsStrength of evidenceClinical practiceKidneyTacrolimusDe novoDelphi consensus survey
2023
Evaluation of Opening Offers Early for Deceased Donor Kidneys at Risk of Nonutilization
Kilambi V, Barah M, Formica R, Friedewald J, Mehrotra S. Evaluation of Opening Offers Early for Deceased Donor Kidneys at Risk of Nonutilization. Clinical Journal Of The American Society Of Nephrology 2023, 19: 233-240. PMID: 37943856, PMCID: PMC10861110, DOI: 10.2215/cjn.0000000000000346.Peer-Reviewed Original ResearchUse of an LCP Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians
Wiseman A, Bunnapradist S, Alhamad T, Alloway R, Concepcion B, Cooper M, Formica R, Klein C, Kumar V, Leca N, Shihab F, Taber D, Mulnick S, Bushnell D, Hadi M. Use of an LCP Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians. Journal Of The American Society Of Nephrology 2023, 34: 1032-1033. DOI: 10.1681/asn.20233411s11032d.Peer-Reviewed Original ResearchPhysician Preferences when Selecting Candidates for Lower-Quality Kidney Offers
Sepulveda J, Mehrotra S, Yang J, Schantz K, Becker Y, Formica R, Ladner D, Kaufman D, Friedewald J. Physician Preferences when Selecting Candidates for Lower-Quality Kidney Offers. Clinical Journal Of The American Society Of Nephrology 2023, 18: 1599-1609. PMID: 37729938, PMCID: PMC10723918, DOI: 10.2215/cjn.0000000000000302.Peer-Reviewed Original ResearchConceptsCold ischemia timePanel reactive antibodyIschemia timeMarginal kidneysEjection fractionReactive antibodiesRecipient characteristicsPost-transplant survival scoreSignificant associationKidney Donor Profile IndexKarnofsky performance scoreSerum creatinine levelsHistory of diabetesLow-quality kidneysHLA mismatchesPerformance statusRecipient ageCreatinine levelsDiabetes statusHLA matchCirculatory deathKidney qualityYounger recipientsDonor ageDiscrete choice experimentAdvancing Face Transplantation: A Critical Analysis of Revisions and Long-Term Surgical Outcomes in 10 Cases
Mookerjee V, Kauke-Navarro M, Hauc S, Huelsboemer L, Formica R, Pomahac B. Advancing Face Transplantation: A Critical Analysis of Revisions and Long-Term Surgical Outcomes in 10 Cases. Plastic & Reconstructive Surgery 2023, 154: 577e-584e. PMID: 37699110, DOI: 10.1097/prs.0000000000011058.Peer-Reviewed Original ResearchMedical recordsLong-term surgical outcomesFace transplantationChronic allograft rejectionMedian time intervalLong-term outcomesComplex facial injuriesPatients' medical recordsFace transplantFace transplant recipientsAllograft rejectionTransplant recipientsSurgical revisionSurgical outcomesMajority of revisionsOperative reportsRevision surgeryProvider teamRetrospective analysisTEN casesFacial injuriesPeriorbital tissuesPatientsTransplantationMost interventions
Clinical Trials
Current Trials
Kidney Transplantation in Recipients and Donors with HIV: Long Term Follow up Study
HIC ID2000030204RoleSub InvestigatorPrimary Completion Date03/31/2031Recruiting ParticipantsGenderBothAge18+ yearsHOPE in Action Prospective Multicenter, Clinical Trial of Deceased HIVD+ Kidney Transplants for HIV+ Recipients
HIC ID2000022391RoleSub InvestigatorPrimary Completion Date08/01/2021Recruiting ParticipantsGenderBothAge18+ yearsMulticenter, Open Label, Phase 3 Trial of ATA129 for Solid Organ Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy (ALLELE Study)
HIC ID2000021894RoleSub InvestigatorPrimary Completion Date06/30/2022Recruiting ParticipantsGenderBoth
Academic Achievements & Community Involvement
Clinical Care
Overview
Richard Formica, MD, is a nephrologist and the director of transplant medicine at Yale Medicine. He received his medical education at Boston University School of Medicine before arriving at Yale in 1997.
As the director for transplant medicine, Dr. Formica strives to make his program a medical home for transplant patients. These patients tend to have a complex variety of needs that may be difficult for other physicians to address. Since arriving here, Dr. Formica has expanded Yale Medicine’s transplant program to include support staff, such as dietitians and social workers. “We wanted to be the one place where transplant patients can have all of their primary needs met so they wouldn’t have to move around to different physicians,” Dr. Formica says.
Dr. Formica’s relationships with his patients often span many years—sometimes beginning before the transplantation. He sees this relationship as a whole rather than as individual clinic visits. “I tell them, ‘Instead of thinking of this as 32 clinic visits over the course of a year, think of it as one experience,’” he says.
As a physician, Dr. Formica aims to keep things casual with his patients. He encourages them to use his first name and learns as much as he can about them, including aspects of their lives unrelated to their disease such as their pets, jobs and hobbies. He has a keen interest in how the disease is affecting his patients: “When I was younger, it was the physiology that drew me to nephrology. Now, what interesting to me is how the patient responds to their disease,” he says.
In addition to treating patients, Dr. Formica is involved in public policy work related to kidney transplantation. He helped develop the kidney allocation system for the country that went into effect in 2014 and he’s also involved in clinical trials for drugs that treat hypertension. At the Yale School of Medicine, he is a professor of medicine (nephrology) and surgery (transplant).
Clinical Specialties
Fact Sheets
Kidney Transplant
Learn More on Yale MedicineLiving Donor Organ Transplantation
Learn More on Yale MedicineLiver Transplant
Learn More on Yale MedicineAnesthesia for Organ Transplant
Learn More on Yale Medicine
Yale Medicine News
News & Links
News
- October 24, 2023
Yale Contributions Shape ASN Kidney Week 2023
- March 21, 2023
Formica Elected Vice President/President-elect of OPTN
- May 03, 2022
Yale Cancer Center and Smilow Cancer Hospital physicians recognized as Connecticut Magazine 'Best Doctors'
- March 21, 2022
Yale Cardiovascular Medicine Appoints New Director, Cardiac Catheterization Laboratories