Ming Lu, MD

2026

• CCR5 drives glucose metabolic reprogramming to control microglial synaptic pruning via histone lactylation in a mouse model of depression

  Jiao Y, Zhu Z, Wang R, He B, Yao H, Zhou Z, Shi Y, Wang C, Cao L, Liu Y, Hu G, Du R, Lu M. CCR5 drives glucose metabolic reprogramming to control microglial synaptic pruning via histone lactylation in a mouse model of depression. Cell Reports 2026, 45: 117749. PMID: 42531126, DOI: 10.1016/j.celrep.2026.117749.

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• Targeting of CH25H to boost p62-dependent autophagic degradation of α-synuclein in cell and mouse models of Parkinson’s disease

  Zhang X, Han R, Zhang W, Xu S, Wang Y, Wang M, Du R, Liu Y, Zhang L, Wang C, Zhang K, Hu G, Xu H, Cao L, Lu M. Targeting of CH25H to boost p62-dependent autophagic degradation of α-synuclein in cell and mouse models of Parkinson’s disease. Science Translational Medicine 2026, 18: eadv7705. PMID: 42418556, DOI: 10.1126/scitranslmed.adv7705.

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• Piriform cortex gates learned fear through a brain-spleen neuroimmune axis

  Yao H, Qu M, Du R, Zhou Z, Geng Y, Zhu Z, Liu Y, Wang C, Hu G, Cao L, Lu M. Piriform cortex gates learned fear through a brain-spleen neuroimmune axis. Neuron 2026 PMID: 42285095, DOI: 10.1016/j.neuron.2026.05.023.

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• HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells

  Yang J, Lin Q, Gu D, Gao J, Liu Y, Yang K, Zhu Z, Lu C, Li D, Ci S, Lin F, Wang Q, Qian X, You Y, Zhou Q, Wang X, Lu M, Zhang Q, Chen Y, Tao W, Zhang J. HSPA6 maintains IMPDH2 phosphorylation to regulate GTP synthesis for driving radioresistance of glioblastoma stem cells. Cell Reports 2026, 45: 117490. PMID: 42234559, DOI: 10.1016/j.celrep.2026.117490.

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• Macrophage piezo1 senses mechanical force to drive osteoclastogenesis via ZBP1: Implications for bone remodelling therapy

  Zhu L, Zhang K, Song A, Zhao W, Lin Y, Xu H, Jin Z, Wang Y, Wu S, Sun X, Gu H, Lu M, Zhang H, Yan B. Macrophage piezo1 senses mechanical force to drive osteoclastogenesis via ZBP1: Implications for bone remodelling therapy. Clinical And Translational Medicine 2026, 16: e70703. PMID: 42175670, PMCID: PMC13239690, DOI: 10.1002/ctm2.70703.

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• G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit

  Wang H, Wei Y, Gao A, Guo J, Ding X, Yang J, Wang Z, Da J, Kang Y, Ding J, Fan Y, Lu M, Zhang L, Hu G. G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit. Acta Pharmacologica Sinica 2026, 47: 2377-2391. PMID: 42168639, PMCID: PMC13487307, DOI: 10.1038/s41401-026-01824-7.

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• Mechanisms underlying neuroimmune networks as central regulators in combating neurodegenerative diseases.

  Hu X, Yao M, Xu F, Wang H, Lu M, Qiao C. Mechanisms underlying neuroimmune networks as central regulators in combating neurodegenerative diseases. Neural Regeneration Research 2026, 21: 5126-5136. PMID: 41975599, DOI: 10.4103/nrr.nrr-d-25-01276.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nicotine-withdrawal-induced anxiety

  Zheng Z, Min P, Luo Y, Mao X, Zhang Y, Liu X, Lu M, Xu E, Han F, Lu Y. Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nicotine-withdrawal-induced anxiety. Neuron 2026, 114: 2441-2455.e7. PMID: 41903536, DOI: 10.1016/j.neuron.2026.02.020.

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• Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation

  Cai L, Zhang Y, Li J, Hu L, Meng Q, Shao J, Deng H, Liu Y, Liu J, Liang Y, Song N, Ding J, Fan Y, Lu M, Fang Y, Hu G. Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation. Cell Death & Disease 2026, 17: 319. PMID: 41881908, PMCID: PMC13039679, DOI: 10.1038/s41419-026-08557-9.

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• Bioinformatics Combined With Biological Experiments to Explore the Promotion of Lung Metastasis by CCL18 in the Immune Microenvironment of Colorectal Cancer

  Xia Q, Yin S, Chen J, Wang H, Shi Y, Li J, Yuan Z, Wang Z, Lu M, Zhao Q, Wei W, Ma X. Bioinformatics Combined With Biological Experiments to Explore the Promotion of Lung Metastasis by CCL18 in the Immune Microenvironment of Colorectal Cancer. Human Mutation 2026, 2026: 1943814. PMID: 42170304, PMCID: PMC13189452, DOI: 10.1155/humu/1943814.

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