Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsLokesh Kumar Sharma, PhD
Assistant Professor AdjunctAbout
Research
Publications
2025
Integrative single-cell RNA and ATAC sequencing reveals the impact of chronic cigarette smoking on lung epithelial responses to influenza and hyperoxia
Cha P, Zou Z, Nouws J, Brewster R, Dela Cruz C, Sharma L, Yan X, Sauler M. Integrative single-cell RNA and ATAC sequencing reveals the impact of chronic cigarette smoking on lung epithelial responses to influenza and hyperoxia. Respiratory Research 2025 PMID: 41366391, DOI: 10.1186/s12931-025-03393-5.Peer-Reviewed Original ResearchChronic CS exposureTranscription factor motif enrichmentCS exposureEpithelial programETS family factorsSusceptibility to acute lung injuryResponse to influenzaMotif enrichmentATAC-seqAcute lung injuryTranscriptional regulationSingle-cell RNAATAC sequencingEpigenetic contextEpithelial subsetsEpithelial responsesProof-of-principle studyLung injuryDifferentiation pathwayChanges in vivoBackgroundCigarette smokingInflammatory signalingAberrant responsesCiliated cellsHyperoxiaStroke-associated pneumonia impairs neurological recovery through upregulation of interferon signaling in mice 3035
Velazquez S, Simoes L, Boisserand B, Sharma L, Tran T, Chen B, Kim J, Dela Cruz C, Sansing L. Stroke-associated pneumonia impairs neurological recovery through upregulation of interferon signaling in mice 3035. The Journal Of Immunology 2025, 214 DOI: 10.1093/jimmun/vkaf283.877.Peer-Reviewed Original ResearchTransient middle cerebral artery occlusionLong-term deficitsClinical complicationsUpregulation of interferon signalingCD8+ T cellsMiddle cerebral artery occlusionIntratracheal inoculationCerebral artery occlusionStroke-associated pneumoniaIL-6 productionIFNy productionWhite blood cellsSham miceImmune infiltrationLy6G+ neutrophilsSham surgeryT cellsImmune cellsNeurological deficitsPoor outcomeNeurological recoveryInfected miceArtery occlusionIL-6Klebsiella pneumoniaeIL‐6 signaling regulates the inflammatory response without impacting pathogen burden during influenza‐associated pulmonary aspergillosis
Sharma L, Singh R, Tolman N, Ngeow C, Duray A, Naghshtabrizi N, Ahmad A, Bain W, Robinson K. IL‐6 signaling regulates the inflammatory response without impacting pathogen burden during influenza‐associated pulmonary aspergillosis. Physiological Reports 2025, 13: e70372. PMID: 40420617, PMCID: PMC12106949, DOI: 10.14814/phy2.70372.Peer-Reviewed Original ResearchConceptsAF infectionAspergillus fumigatusInterleukin-6IL-6 signalingLung inflammationInfluenza-associated pulmonary aspergillosisInterleukin-6 knockout miceNeutrophilic lung inflammationBronchoalveolar lavage fluidEpithelial cell damageLung capillary permeabilitySusceptibility to opportunistic pathogensPulmonary aspergillosisClinical courseLavage fluidKnockout miceOpportunistic pathogenRAGE levelsEpithelial integrityMouse modelIL-6Pathological inflammationTissue injuryInflammatory responseViral infectionProphylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study
Hu H, Zhu Y, Hu R, Zhao L, Zeng X, Wu X, Qiu R, Nie Y, Sharma L, Chang D. Prophylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study. Frontiers In Pharmacology 2025, 16: 1597885. PMID: 40406481, PMCID: PMC12095157, DOI: 10.3389/fphar.2025.1597885.Peer-Reviewed Original ResearchProphylactic anticoagulant therapyShort-term mortalityKaplan-Meier survival analysisAnticoagulant therapyICU patientsPropensity score matchingPulmonary infectionImproved survivalNon-COVID-19Subgroup analysisNon-COVID-19 pneumoniaDuration of anticoagulant therapyAssociated with improved survivalMultivariate Cox regression modelSurvival analysisEffect of anticoagulant therapyMedical Information Mart for Intensive Care IV databaseCox regression analysisRetrospective cohort studyAssociated with reduced short-term mortalityOptimal administration strategiesCox regression modelsPrognostic factorsAnticoagulation groupCoagulation disordersEpidermal Growth Factor Receptor Regulates Beclin-1 and Autophagy in Hyperoxic Acute Lung Injury
Harris Z, Korde A, Khoury J, Manning E, Stanley G, Sun Y, Hu B, Shin H, Joerns J, Clark B, Mitchell K, Placek L, Unutmaz D, Moldobaeva A, Sharma L, Sauler M, Rajagopalan G, Zhang X, Wang H, Ghaedi M, Kang M, Koff J. Epidermal Growth Factor Receptor Regulates Beclin-1 and Autophagy in Hyperoxic Acute Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2472-a2472. DOI: 10.1164/ajrccm.2025.211.abstracts.a2472.Peer-Reviewed Original ResearchLower Respiratory Tract C. Albicans Induces Lung Injury in Mice and Associates With Lung Injury Endpoints in Humans
Tolman N, Choi W, Alder J, Tabary M, Qin S, Wang X, Zhang Y, Tu Y, Sharma L, Bon J, Robinson K, Snyder M, Dela Cruz C, Nguyen M, Morris A, Biswas P, Bain W, Kitsios G. Lower Respiratory Tract C. Albicans Induces Lung Injury in Mice and Associates With Lung Injury Endpoints in Humans. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a2825-a2825. DOI: 10.1164/ajrccm.2025.211.abstracts.a2825.Peer-Reviewed Original ResearchDichotomous Effects of TLR9 on Early Inflammation and Viral Clearance Dictates Recovery From Influenza Infection
Kim J, Yuan Y, Agaronyan K, Zhao A, Bain W, Evankovich J, Dela Cruz C, Ryu C, Sharma L. Dichotomous Effects of TLR9 on Early Inflammation and Viral Clearance Dictates Recovery From Influenza Infection. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a4707-a4707. DOI: 10.1164/ajrccm.2025.211.abstracts.a4707.Peer-Reviewed Original ResearchAcute Exacerbation of Interstitial Lung Disease Is Associated With Significantly Increased Mortality Compared to Acute Respiratory Distress Syndrome Despite Lower Systemic Inflammation
Deberry J, Kitsios G, Bain W, Sharma L, Dela Cruz C, Seedahmed M, Zhang Y, Kass D, Valenzi E, Mcverry B, Shah F. Acute Exacerbation of Interstitial Lung Disease Is Associated With Significantly Increased Mortality Compared to Acute Respiratory Distress Syndrome Despite Lower Systemic Inflammation. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5653-a5653. DOI: 10.1164/ajrccm.2025.211.abstracts.a5653.Peer-Reviewed Original ResearchElectronic Cigarettes Exaggerate Influenza A Virus-induced Cell Death in Alveolar Epithelial Cells
Villandre J, Chandler M, Tuncer F, Tuncer B, Lear T, Sharma L, Chen B, Dela Cruz C, Evankovich J. Electronic Cigarettes Exaggerate Influenza A Virus-induced Cell Death in Alveolar Epithelial Cells. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a6602-a6602. DOI: 10.1164/ajrccm.2025.211.abstracts.a6602.Peer-Reviewed Original ResearchChitotriosidase in Influenza Lung Infection
Kim J, Amick A, Villandre J, Bain W, Evankovich J, Sharma L, Dela Cruz C. Chitotriosidase in Influenza Lung Infection. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7920-a7920. DOI: 10.1164/ajrccm.2025.211.abstracts.a7920.Peer-Reviewed Original Research