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Lawrence Hirsch, MD

Professor of Neurology
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Additional Titles

Director, Fellowship Program, Neurophysiology

Chief, Division of Epilepsy and EEG

Co-Director, Yale Comprehensive Epilepsy Center

Co-Director, Critical Care EEG Monitoring Program

About

Titles

Professor of Neurology

Director, Fellowship Program, Neurophysiology; Chief, Division of Epilepsy and EEG; Co-Director, Yale Comprehensive Epilepsy Center; Co-Director, Critical Care EEG Monitoring Program

Biography

Lawrence J. Hirsch, M.D. is Professor of Neurology, Academic Chief of the Division of Epilepsy and EEG, and Co-Director of the Comprehensive Epilepsy Center, all at Yale University. He has held leadership positions in the American Clinical Neurophysiology Society (ACNS), American Epilepsy Society, American Academy of Neurology, and the Epilepsy Foundation. He is lead author of the 2012 and 2021 ACNS guidelines on critical care EEG terminology and senior author of the ACNS guideline on Critical Care EEG Monitoring. He is founder and former chair of the Critical Care EEG Monitoring Research Consortium; co-chair of the medical advisory board of the NORSE Institute; first author of the manuscript defining NORSE and FIRES; co-P.I. of the NORSE Multicenter study; and Principal Investigator of the NORSE/FIRES Open Biorepository housed at Yale University. He was the first to recognize the localizing and lateralizing value of postictal nosewiping, and he described and coined the term SIRPIDs. He has an H index of 90 with >31,000 citations, more than half of which are after 2019. He has published more than 230 peer-reviewed manuscripts and more than 100 reviews, editorials or book chapters on topics including status epilepticus, all aspects of EEG including intracranial recordings and brain monitoring in the critically ill, brain stimulation, epilepsy surgery, seizure clusters, rescue medications, SUDEP, and anti-seizure medication use. He has won multiple teaching awards, mentored dozens of trainees, and is co-author of the first-ever atlas on EEG in critical care, now with multiple editions.

Last Updated on July 22, 2025.

Appointments

Education & Training

Fellowship
Columbia Presbyterian Medical Center (1997)
Residency
Columbia Presbyterian Center (1995)
Intern
Yale University (1992)
MD
Yale University School of Medicine
BA
University of Pennsylvania

Research

Overview

Research publications via PubMed.

Medical Research Interests

Deep Brain Stimulation; Electroencephalography; Epilepsia Partialis Continua; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Complex Partial; Epilepsy, Frontal Lobe; Epilepsy, Generalized; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Implantable Neurostimulators; Seizures; Status Epilepticus

Research at a Glance

Yale Co-Authors

Frequent collaborators of Lawrence Hirsch's published research.

Publications

2025

Clinical Trials

Current Trials

Academic Achievements & Community Involvement

Activities

  • activity

    Nonconvulsive seizures in the critically ill: continuous EEG, quantitative EEG and COVID-19

  • activity

    Epilepsy and EEG Collaborative Topics

  • activity

    The role of continuous EEG in the ICU; and Seizure clusters and rescue therapy

  • activity

    The neurophysiology of SUDEP; Recordings from the responsive neurostimulation system; The EEG in status epilepticus (plenary)

  • activity

    Nonconvulsive seizures and status epilepticus in the critically ill: the silent epidemic; Chronic brain stimulation for treatment of epilepsy

Honors

  • honor

    Insley Lecturer

  • honor

    Fellow

  • honor

    Attending of the Year

  • honor

    Keynote Speaker

  • honor

    Sahlie Distinguished Lecturer

Clinical Care

Overview

Lawrence J. Hirsch, MD, is Professor of Neurology, Chief of the Division of Epilepsy and EEG, Co-Director of the Yale Comprehensive Epilepsy Center, and Co-Director of the Critical Care EEG Monitoring Program.

Yale's epilepsy center, which has existed for over 50 years, was one of the first centers of its kind, internationally known for its clinical excellence and innovative research for adult and pediatric patients. His goal in caring for patients with epilepsy is to return them to the point where they can live normal, seizure-free lives. “Over the years, we have cured several hundreds of patients of their chronic, disabling seizures. It's immensely satisfying for everyone,” he says.

Dr. Hirsch is an active researcher in such areas as epilepsy surgery, brain stimulation to treat epilepsy, anti-seizure medications, seizure clusters, and brain monitoring in the critically ill. He has published over 200 manuscripts, has won multiple teaching awards, and speaks internationally on a regular basis. He is excited about the development of less invasive, more tolerable techniques and tools, including stimulators and lasers, which provide excellent options in even the most difficult cases.

One of the greatest challenges in the field is that many patients do not obtain access to the best tests and treatments, Dr. Hirsch says. “My goal is to help close this gap in access to care via telemedicine, home video/EEG services, remote consults, and educational outreach to patients, families, and clinicians,” he says. “We will continue to push our ability to prevent or cure epilepsy in as many people as possible, and to maximize quality of life in all people with seizures.”

Dr. Hirsch has been included in Castle Connolly Medical Ltd.’s lists of Top Doctors.

Clinical Specialties

Neurology; Epilepsy & Seizures

Fact Sheets

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