2025
Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches.
Cakir B, Tanaka Y, Choe M, Chu P, Xiang Y, Kim K, Zhong M, Gelernter J, Zhang H, Krystal J, Park I. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. International Journal Of Stem Cells 2025 PMID: 40205763, DOI: 10.15283/ijsc24123.Peer-Reviewed Original ResearchHuman embryonic stem cell linesAlcohol dependenceAD-associated variantsEmbryonic stem cell linesReporter gene analysisFyn tyrosine kinase geneTyrosine kinase geneStem cell linesCRISPR-Cas9 editingAssociated with ADVulnerability to ADAD-associatedKinase geneC alleleC/T allelesMultiple polymorphismsFunctional validationGene analysisEthanol treatmentNeuropsychiatric disordersInduced neuronsAD treatmentGene editingCell linesDisease mechanisms
2018
Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids
Xiang Y, Yoshiaki T, Patterson B, Cakir B, Kim K, Cho YS, Park I. Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids. Current Protocols In Stem Cell Biology 2018, 47 PMID: 30854156, PMCID: PMC6402040, DOI: 10.1002/cpsc.61.Peer-Reviewed Original ResearchConceptsMedial ganglionic eminenceBrain organoidsBrain regionsBrain developmentSpecific brain regionsDifferent brain regionsHuman CorticalHuman brain developmentCortical organoidsGanglionic eminenceNeurological disordersInterneuron migrationSpecific regionalizationOrganoid culturesOrganoidsBrain organoid culture
2012
The lesser known story of X chromosome reactivation
Hysolli E, Tanaka Y, Kim K, Jung Y, Park IH. The lesser known story of X chromosome reactivation. Cell Cycle 2012, 11: 229-235. PMID: 22234239, PMCID: PMC3293375, DOI: 10.4161/cc.11.2.18998.Peer-Reviewed Original ResearchConceptsX chromosome reactivationX-chromosome inactivationInner cell massActive histone marksGerm cell formationX inactivation signalHistone marksActive chromosomeCellular reprogrammingInactivation signalGene poolPluripotent cellsKey regulatorFemale cellsGene expressionGerm layersCell formationXY cellsCell massImportant mechanismNatural occurrenceCellsReprogrammingChromosomesGenes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply