Hua Xu, PhD
he/him/his
Robert T. McCluskey Professor of Biomedical Informatics and Data ScienceDownloadHi-Res Photo
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Appointments
Additional Titles
Vice Chair for Research and Development, Department of Biomedical Informatics and Data Science
Assistant Dean for Biomedical Informatics, Yale School of Medicine
Contact Info
Biomedical Informatics & Data Science
100 College St
New Haven, Connecticut 06510
United States
Appointments
Additional Titles
Vice Chair for Research and Development, Department of Biomedical Informatics and Data Science
Assistant Dean for Biomedical Informatics, Yale School of Medicine
Contact Info
Biomedical Informatics & Data Science
100 College St
New Haven, Connecticut 06510
United States
Appointments
Additional Titles
Vice Chair for Research and Development, Department of Biomedical Informatics and Data Science
Assistant Dean for Biomedical Informatics, Yale School of Medicine
Contact Info
Biomedical Informatics & Data Science
100 College St
New Haven, Connecticut 06510
United States
About
Titles
Robert T. McCluskey Professor of Biomedical Informatics and Data Science
Vice Chair for Research and Development, Department of Biomedical Informatics and Data Science; Assistant Dean for Biomedical Informatics, Yale School of Medicine
Biography
Dr. Hua Xu is a well-known researcher in clinical natural language processing (NLP). He has developed novel algorithms for important clinical NLP tasks such as entity recognition and relation extraction, which have been top ranked in over a dozen of international biomedical NLP challenges. His lab has developed CLAMP, a comprehensive clinical NLP toolkit that has been successfully commercialized and used by hundreds of healthcare organizations. Moreover, he has led multiple national/international initiatives (e.g., Chair of the NLP working group at Observational Health Data Sciences and Informatics - OHDSI program) to apply developed NLP technologies to diverse clinical and translational studies, thus greatly accelerating clinical evidence generation using electronic health records data. Recently, he also utilizes NLP to harmonize metadata of biomedical digital objects (e.g., indexing millions of biomedical datasets to make them findable), with the goal to promote FAIR principles in biomedicine. Currently Dr. Xu's lab is actively working on developing large language models for diverse biomedical applications. See more information about Dr. Xu's lab here.
Appointments
Biomedical Informatics & Data Science
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Columbia University, Biomedical Informatics
- MS
- New Jersey Institute of Technology, Computer Science
- BS
- Nanjing University, Biochemistry
Research
Overview
Medical Subject Headings (MeSH)
Natural Language Processing
ORCID
0000-0001-9730-7276- View Lab Website
Clinical NLP Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Hua Xu's published research.
Publications Timeline
A big-picture view of Hua Xu's research output by year.
Research Interests
Research topics Hua Xu is interested in exploring.
Lucila Ohno-Machado, MD, MBA, PhD
Vipina K. Keloth, PhD
Qingyu Chen, PhD
Tsung-Ting Kuo, PhD
Huan He, PhD
Jihoon Kim, PhD
309Publications
11,689Citations
Natural Language Processing
Publications
2024
Ascle—A Python Natural Language Processing Toolkit for Medical Text Generation: Development and Evaluation Study
Yang R, Zeng Q, You K, Qiao Y, Huang L, Hsieh C, Rosand B, Goldwasser J, Dave A, Keenan T, Ke Y, Hong C, Liu N, Chew E, Radev D, Lu Z, Xu H, Chen Q, Li I. Ascle—A Python Natural Language Processing Toolkit for Medical Text Generation: Development and Evaluation Study. Journal Of Medical Internet Research 2024, 26: e60601. PMID: 39361955, DOI: 10.2196/60601.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNatural language processingNatural language processing toolkitQuestion-answering taskLanguage modelText generationText processingDomain-specific language modelsNatural language processing functionsMinimal programming expertiseText generation tasksMedical knowledge graphMachine translation tasksROUGE-L scoreDomain-specific challengesAll-in-one solutionROUGE-LText summarizationBLEU scoreKnowledge graphMachine translationUnstructured textQuestion-answeringHugging FaceProcessing toolkitLanguage processingAugmenting biomedical named entity recognition with general-domain resources
Yin Y, Kim H, Xiao X, Wei C, Kang J, Lu Z, Xu H, Fang M, Chen Q. Augmenting biomedical named entity recognition with general-domain resources. Journal Of Biomedical Informatics 2024, 104731. PMID: 39368529, DOI: 10.1016/j.jbi.2024.104731.Peer-Reviewed Original ResearchConceptsBioNER datasetsMulti-task learningNER datasetsEntity typesBiomedical datasetsBaseline modelGeneral domain datasetsBiomedical language modelNeural network-basedYield performance improvementsBioNER modelsEntity recognitionBiomedical corporaHuman annotatorsLabel ambiguityLanguage modelTransfer learningF1 scoreBioNERHuman effortNetwork-basedBiomedical resourcesPerformance improvementDatasetSuperior performanceRelation extraction using large language models: a case study on acupuncture point locations
Li Y, Peng X, Li J, Zuo X, Peng S, Pei D, Tao C, Xu H, Hong N. Relation extraction using large language models: a case study on acupuncture point locations. Journal Of The American Medical Informatics Association 2024, ocae233. PMID: 39208311, DOI: 10.1093/jamia/ocae233.Peer-Reviewed Original ResearchAltmetricConceptsAcupuncture point locationsAcupoint locationLocation of acupointsClinical decision supportAcupuncture knowledgeAcupuncture trainingAcupuncture therapyAcupunctureAcupointsComplementary medicineEducational moduleWestern Pacific RegionInformatics applicationsDecision supportScoresGenerative Pre-trained TransformerWHO standardsF1 scoreLanguage modelPacific regionWHODomain-specific fine-tuningTrainingStudyMicro-averaged F1 scoreBalancing the efforts of chart review and gains in PRS prediction accuracy: An empirical study
Lei Y, Christian Naj A, Xu H, Li R, Chen Y. Balancing the efforts of chart review and gains in PRS prediction accuracy: An empirical study. Journal Of Biomedical Informatics 2024, 157: 104705. PMID: 39134233, DOI: 10.1016/j.jbi.2024.104705.Peer-Reviewed Original ResearchConceptsAlzheimer's Disease Genetics ConsortiumChart reviewPRS modelCase-control datasetGenetic association analysisGenetics ConsortiumPhenotype misclassificationSimulated phenotypesPhenotypic dataAssociation analysisEstimation of associated parametersBias reduction methodMedian thresholdPhenotypeMisclassification rateOriginal phenotypeDiverse arrayChartsMisclassificationGenotypesReviewEffects of biasBiasPrediction modelPRSLeveraging error-prone algorithm-derived phenotypes: Enhancing association studies for risk factors in EHR data
Lu Y, Tong J, Chubak J, Lumley T, Hubbard R, Xu H, Chen Y. Leveraging error-prone algorithm-derived phenotypes: Enhancing association studies for risk factors in EHR data. Journal Of Biomedical Informatics 2024, 157: 104690. PMID: 39004110, DOI: 10.1016/j.jbi.2024.104690.Peer-Reviewed Original ResearchConceptsElectronic health recordsElectronic health record dataKaiser Permanente WashingtonEHR-derived phenotypesAssociation studiesHealth recordsColon cancer recurrencePhenotyping errorsComputable phenotypeRisk factorsCancer recurrenceMultiple phenotypesReduce biasImprove estimation accuracySimulation studyBias reductionKaiserReduction of biasBiasEstimation accuracyAssociationStudyOutcomesRiskEstimation efficiencyDevelop and validate a computable phenotype for the identification of Alzheimer's disease patients using electronic health record data
He X, Wei R, Huang Y, Chen Z, Lyu T, Bost S, Tong J, Li L, Zhou Y, Li Z, Guo J, Tang H, Wang F, DeKosky S, Xu H, Chen Y, Zhang R, Xu J, Guo Y, Wu Y, Bian J. Develop and validate a computable phenotype for the identification of Alzheimer's disease patients using electronic health record data. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2024, 16: e12613. PMID: 38966622, PMCID: PMC11220631, DOI: 10.1002/dad2.12613.Peer-Reviewed Original ResearchAltmetricConceptsElectronic health record dataElectronic health recordsComputable phenotypeHealth record dataManual chart reviewHealth recordsAlzheimer's diseaseDiagnosis codesRecord dataChart reviewUTHealthAlzheimer's disease patientsUniversity of MinnesotaAD diagnosisAD identificationDisease patientsPatientsAlzheimerAD patientsDemographicsDiagnosisDiseaseCodeDataUniversityExtracting Systemic Anticancer Therapy and Response Information From Clinical Notes Following the RECIST Definition
Zuo X, Kumar A, Shen S, Li J, Cong G, Jin E, Chen Q, Warner J, Yang P, Xu H. Extracting Systemic Anticancer Therapy and Response Information From Clinical Notes Following the RECIST Definition. JCO Clinical Cancer Informatics 2024, 8: e2300166. PMID: 38885475, DOI: 10.1200/cci.23.00166.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNatural language processingDomain-specific language modelsNatural language processing systemsInformation extraction systemRule-based moduleNarrative clinical textsNLP tasksEntity recognitionText normalizationAssertion classificationLanguage modelInformation extractionClinical textElectronic health recordsLearning-basedClinical notesLanguage processingTest setSystem performanceHealth recordsResponse extractionTime-consumingAnticancer therapyInformationAssessment informationNLP Applications—Other Biomedical Texts
Roberts K, Xu H, Demner Fushman D. NLP Applications—Other Biomedical Texts. Cognitive Informatics In Biomedicine And Healthcare 2024, 429-444. DOI: 10.1007/978-3-031-55865-8_15.Peer-Reviewed Original ResearchIntroduction to Natural Language Processing of Clinical Text
Demner Fushman D, Xu H. Introduction to Natural Language Processing of Clinical Text. Cognitive Informatics In Biomedicine And Healthcare 2024, 3-11. DOI: 10.1007/978-3-031-55865-8_1.Peer-Reviewed Original ResearchConceptsNatural language processingLanguage processingComplex language processingBiomedical natural language processingClinical natural language processingLanguage generation tasksClinical language processingBiomedical language processingLanguage modelClinical textGeneration taskMachine learningDelivery of informationClinical languageLanguageMedical Concept Normalization
Xu H, Demner Fushman D, Hong N, Raja K. Medical Concept Normalization. Cognitive Informatics In Biomedicine And Healthcare 2024, 137-164. DOI: 10.1007/978-3-031-55865-8_6.Peer-Reviewed Original ResearchConceptsConcept normalizationDeep learning-based techniquesMedical concept normalizationLearning-based techniquesContemporary machine learningRule-based methodologyAnnotated corpusNLP systemsMachine learningComputing applicationsBiomedical terminologiesNormalization approachStandardized terminologyOntologyTaskLearning
News
News
- October 21, 2024
Yale BIDS Presenting at the AMIA 2024 Annual Symposium
- October 02, 2024
NIH Awards $1.5 Million Grant to Improve Factual Correctness in Large Language Models in Health Care
- September 27, 2024
Biomedical Informatics and Data Science (BIDS) Secures a $7.88 Million NIH Grant to Advance Mental Health Research Using AI Technology
- September 23, 2024
Advancing Clinical Decision Support with Reliable, Transparent Large Language Models
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Biomedical Informatics & Data Science
100 College St
New Haven, Connecticut 06510
United States