Erica Spatz, MD, MHS
Associate Professor of Cardiology and Associate Professor of Epidemiology (Chronic Diseases)Cards
About
Research
Publications
2025
Long COVID as Intermediate Physiology Rethinking Autonomic Dysfunction and Medical Uncertainty
Sawano M, Spatz E, Sanders L. Long COVID as Intermediate Physiology Rethinking Autonomic Dysfunction and Medical Uncertainty. Journal Of The American College Of Cardiology 2025 PMID: 41405529, DOI: 10.1016/j.jacc.2025.10.083.Peer-Reviewed Original ResearchConfronting the Global Rise of Obesity and Cardiovascular Disease The Role of GLP-1 RAs
Spatz E. Confronting the Global Rise of Obesity and Cardiovascular Disease The Role of GLP-1 RAs. Journal Of The American College Of Cardiology 2025, 86: 2155-2157. PMID: 41298033, DOI: 10.1016/j.jacc.2025.09.1599.Peer-Reviewed Original ResearchGearing Up for Lipoprotein(a) Screening and Management Distributions and Risk in the Hispanic/Latino Population
Spatz E. Gearing Up for Lipoprotein(a) Screening and Management Distributions and Risk in the Hispanic/Latino Population. Journal Of The American College Of Cardiology 2025, 86: 2311-2313. PMID: 41338841, DOI: 10.1016/j.jacc.2025.10.034.Peer-Reviewed Original ResearchAge-Specific Associations Between Adiposity and Mortality in U.S. Adults, 1999-2018
Lu Y, Mou Y, Liu Y, Chen A, Herrin J, Spatz E, Sharifi M, Jastreboff A, Krumholz H. Age-Specific Associations Between Adiposity and Mortality in U.S. Adults, 1999-2018. JACC Advances 2025, 4: 102234. PMID: 41205545, PMCID: PMC12639814, DOI: 10.1016/j.jacadv.2025.102234.Peer-Reviewed Original ResearchU.S. adultsBody mass indexMortality HRAssociated with elevated all-cause mortalityNational Health and Nutrition Examination SurveyWaist-to-height ratioHealth and Nutrition Examination SurveyElevated all-cause mortalityMass indexYoung adultsNutrition Examination SurveySample of U.S. adultsAge-specific associationsClass 3 obesityAll-Cause MortalityCox proportional hazards modelsAge-tailored interventionAdiposity measuresExamination SurveyProportional hazards modelWaist circumferenceMortality dataAll-CauseUnderweight statusAnthropometric measurementsThe 2025 High Blood Pressure Guideline A Needed Reboot
Spatz E. The 2025 High Blood Pressure Guideline A Needed Reboot. Journal Of The American College Of Cardiology 2025, 86: 1462-1463. PMID: 41162003, DOI: 10.1016/j.jacc.2025.09.010.Peer-Reviewed Original Research30-Year Cardiovascular Risk in Comparison With Peers An Effective Cue to Action?
Spatz E. 30-Year Cardiovascular Risk in Comparison With Peers An Effective Cue to Action? Journal Of The American College Of Cardiology 2025, 86: 2028-2030. PMID: 41260757, DOI: 10.1016/j.jacc.2025.10.022.Peer-Reviewed Original ResearchBlood Pressure Control and Maintenance in U.S. Veterans Roles of Sex, Race, Ethnicity, and Deprivation
Gaffey A, Chang T, Dhruva S, Burg M, Haskell S, Bastian L, Spatz E, Levine A, Skanderson M, Brandt C. Blood Pressure Control and Maintenance in U.S. Veterans Roles of Sex, Race, Ethnicity, and Deprivation. JACC Advances 2025, 4: 102267. PMID: 41138531, PMCID: PMC12595360, DOI: 10.1016/j.jacadv.2025.102267.Peer-Reviewed Original ResearchSocial deprivation indexDeprivation indexBP controlU.S. Veterans Affairs Medical CenterVeterans Affairs Medical CenterNH-White patientsOdds of controlAffairs Medical CenterCardiovascular diseaseNH Black patientsBlood pressureNew-onset hypertensionRetrospective cohort studyAdequate follow-upYounger veteransSociodemographic characteristicsSociodemographic variablesZip codesHispanic patientsHypertension managementU.S. veteransCohort studyLogistic regressionVeteransWhite patientsClinical profile and long-term outcomes of chest pain patients with coronary microvascular dysfunction from the emergency department – results from the Yale-CMD registry
Safdar B, Zhou B, Li F, Camici P, Dziura J, Jastreboff A, Lansky A, Shah S, Sinusas A, Spatz E, D'Onofrio G. Clinical profile and long-term outcomes of chest pain patients with coronary microvascular dysfunction from the emergency department – results from the Yale-CMD registry. Microvascular Research 2025, 163: 104878. PMID: 41110546, DOI: 10.1016/j.mvr.2025.104878.Peer-Reviewed Original ResearchConceptsCMD patientsCoronary microvascular dysfunctionLong-term prognosisLong-term outcomesCoronary artery diseaseCoronary flow reserveEmergency departmentMicrovascular dysfunctionProspective cohortHeart failureHealthcare utilizationMedian follow-up timeHigh riskCohort of ED patientsMyocardial infarctionCardiac positron emission tomographyHigher adverse eventsChest pain patientsFollow-up timeAdverse cardiac eventsHigher MACE riskHigher healthcare utilizationAnnual follow-upSeattle Angina QuestionnaireProspective cohort of ED patientsAdiposity at the Core of Cardiometabolic Disease A Turning Point
Spatz E. Adiposity at the Core of Cardiometabolic Disease A Turning Point. Journal Of The American College Of Cardiology 2025, 86: 1234-1235. PMID: 41093486, DOI: 10.1016/j.jacc.2025.08.056.Peer-Reviewed Original ResearchMoving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care
Jain S, Mortazavi B, Chan You S, Yao X, Lam C, Elias P, Poterucha T, Avram R, Tison G, Pirruccello J, Huang C, Wiens J, Schwamm L, Ruan X, Dunn J, Luo Y, Spatz E, Krumholz H. Moving Beyond the Model Our Perspective on Meaningful AI Research in Cardiovascular Care. Journal Of The American College Of Cardiology 2025, 86: 691-695. PMID: 40903130, DOI: 10.1016/j.jacc.2025.07.040.Peer-Reviewed Original Research
Clinical Care
Overview
Erica Spatz, MD, MHS, is a general cardiologist who treats a variety of conditions that relate to the heart and circulatory system. In addition to emphasizing prevention to her patients, she is an active researcher who investigates ways to prevent heart attacks and strokes, so that more people can live long and healthy lives.
“The field of prevention is exciting. We are rapidly developing new ways of estimating people’s risk of future heart disease, and we have new medications and tools to reduce that risk,” says Dr. Spatz, who is especially interested in applying “precision medicine” to prevention. This is making conversations with patients in her practice more specific and less generic. “I am thinking, ‘What are the patient’s risk factors? What's unique about their biology, their genetics, and their biography? What are the aspects of their lives that may be contributing to cardiovascular risk or, on the contrary, promoting cardiovascular health? What might be the best strategies for reducing risk and improving their health outcomes?’ The onus is on us as clinicians, physicians, nurses, and pharmacists, to really understand the person before us.”
We need to be working at multiple levels to reduce heart disease, Spatz says. “We need strong policies and coordinated community efforts to promote healthier lifestyles and overall well-being. There is so much we can be doing to make ‘healthy’ the easy choice for our population. At the individual level, there is an opportunity to better capture the personalized biological factors, experiences, and behaviors that inform cardiovascular risk—through digital technology and surveys.”
Lifestyle changes are often considered the bedrock of preventing heart disease, and while this can be difficult for some people—especially if they are overwhelmed with other life challenges—small achievable goals go a long way, Dr. Spatz says. “I try to think about this from a lifelong perspective. Cardiovascular disease prevention is hard work and people can't be perfect all the time, so I try to find specific things people can work on as well as opportunities when this makes sense in a person's life. If I can help them to define a healthier path, then I think the ripple effects can be massive.”
In addition to caring for patients, Dr. Spatz serves as a clinical investigator for the Center for Outcomes Research & Evaluation (CORE), an organization at Yale School of Medicine that focuses on health care quality, where she researches individualized approaches to preventing and managing cardiovascular disease, health disparities across the health care system, and ways to engage patients as partners in their care. She also is a cofounder of Project Access-New Haven—a network of physicians, hospitals, and community organizations partnering to provide donated specialty care to underserved patients in New Haven.
Clinical Specialties
Fact Sheets
Heart Attack (Myocardial Infarction)
Learn More on Yale MedicineFamilial hypercholesterolemia
Learn More on Yale MedicineHypercholesterolemia (High Cholesterol)
Learn More on Yale MedicineCOVID-19
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Board Certifications
Cardiovascular Disease
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2019
- Original Certification Date
- 2013
Yale Medicine News
News & Links
News
- December 29, 2025Source: Yahoo UK - Yahoo Movies UK
75% of US adults may meet criteria for obesity under new definition, study finds
- November 20, 2025Source: Yale Medicine
Yes, Stress Can Hurt Your Heart: 3 Things to Know
- November 18, 2025
Upcoming Conference: Obesity and Genetic Heart Disease in the Era of Preventive Cardiology
- September 18, 2025
Women’s Health Research at Yale Named Founding Member of The Milken Institute’s Women’s Health Network
Get In Touch
Contacts
Cardiovascular Medicine
789 Howard Avenue, PO Box 208017
New Haven, CT 06520-8017
United States
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