2023
A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel group
2022
A Hub and Spoke Model for Improving Access and Standardizing Ethics Consultations Across a Large Healthcare System
Tolchin B, Bruce L, Mercurio M, Latham SR. A Hub and Spoke Model for Improving Access and Standardizing Ethics Consultations Across a Large Healthcare System. The American Journal Of Bioethics 2022, 22: 42-45. PMID: 35420520, DOI: 10.1080/15265161.2022.2044551.Peer-Reviewed Original Research
2021
Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic. The Journal Of Clinical Ethics 2021, 32: 358-360. PMID: 34928864, DOI: 10.1086/jce2021324358.Commentaries, Editorials and LettersConceptsSOFA scoreBlack patientsCrisis standardsSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreAccurate prognostic scoresNext public health emergencyCOVID-19 patientsLife-saving medical resourcesMedical resourcesCOVID-19 pandemicSame scoring systemPublic health emergencyPrognostic scoreBody of evidenceRare casePatientsScoring systemTriage purposesAssessment scoresHealth emergencyCareHealthcare systemCOVID-19ScoresFrailty, an Imperfect ICU Rationing Criterion
Batra RK, Latham SR. Frailty, an Imperfect ICU Rationing Criterion. The American Journal Of Bioethics 2021, 21: 69-71. PMID: 34710005, DOI: 10.1080/15265161.2021.1980142.Peer-Reviewed Original ResearchViolations of Suicide-Prevention Guidelines in US Media Coverage of Physician's Suicide Death During the COVID-19 Pandemic
Lynn-Green E, Jaźwińska K, Beckman A, Latham S. Violations of Suicide-Prevention Guidelines in US Media Coverage of Physician's Suicide Death During the COVID-19 Pandemic. Crisis 2021, 43: 340-343. PMID: 33944606, DOI: 10.1027/0227-5910/a000778.Peer-Reviewed Original ResearchConceptsHealthcare workersSuicide deathsSuicide prevention guidelinesRisk of suicideSuicide reporting guidelinesCOVID-19 pandemicReporting guidelinesElevated riskSuicide guidelinesSubsequent suicideSuicide preventionUnique articlesDeathAdherenceRiskSuicideGuidelinesPandemicSuicide reportingThird of articlesElectronic health record alerts for acute kidney injury: multicenter, randomized clinical trial
Wilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.Peer-Reviewed Original ResearchConceptsAcute kidney injuryElectronic health record alertsKidney injuryPrimary outcomeMedical recordsYale New Haven Health SystemCare practicesGlobal Outcomes creatinine criteriaLarge tertiary care centerComposite of progressionDays of randomizationReceipt of dialysisPrespecified secondary outcomesTertiary care centerPatients' medical recordsSmall community hospitalNon-teaching hospitalsElectronic health recordsCreatinine criteriaUsual careSecondary outcomesAdult inpatientsKidney diseaseClinical centersWorse outcomes
2020
Molecular HIV Surveillance and Public Health Ethics: Old Wine in New Bottles
Dawson L, Latham S. Molecular HIV Surveillance and Public Health Ethics: Old Wine in New Bottles. The American Journal Of Bioethics 2020, 20: 39-41. PMID: 33016834, DOI: 10.1080/15265161.2020.1806393.Peer-Reviewed Original ResearchPersonal Transformation and Advance Directives: An Experimental Bioethics Approach
Earp B, Latham S, Tobia K. Personal Transformation and Advance Directives: An Experimental Bioethics Approach. The American Journal Of Bioethics 2020, 20: 72-75. PMID: 32757927, DOI: 10.1080/15265161.2020.1781964.Peer-Reviewed Original Research
2018
From Interest to Applause to Despair
Latham S. From Interest to Applause to Despair. The American Journal Of Bioethics 2018, 18: 15-17. PMID: 31159690, DOI: 10.1080/15265161.2018.1533737.Peer-Reviewed Original ResearchHuman–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges
De Los Angeles A, Hyun I, Latham S, Elsworth J, Redmond D. Human–Monkey Chimeras for Modeling Human Disease: Opportunities and Challenges. Stem Cells And Development 2018, 27: 1599-1604. PMID: 30319057, PMCID: PMC7366261, DOI: 10.1089/scd.2018.0162.Peer-Reviewed Original ResearchConceptsImportant ethical considerationsModeling Human DiseaseHuman PS cellsInterspecies chimerasUse of monkeysChimera researchEthical considerationsEthical concernsInvasive researchCell researchPolitical issuesScientific valueBiomedical researchLight of advancesHuman stem cellsJurisdictionsPS cellsHoly grailQuestionsAsymmetrical Intuitions
Latham S. Asymmetrical Intuitions. The American Journal Of Bioethics 2018, 18: 54-55. PMID: 30475189, DOI: 10.1080/15265161.2018.1523505.Peer-Reviewed Original Research
2017
Responsibility for Collateral Harm
Latham S. Responsibility for Collateral Harm. The American Journal Of Bioethics 2017, 17: 55-57. PMID: 29020563, DOI: 10.1080/15265161.2017.1366197.Peer-Reviewed Original Research
2016
Moral Distress and Cooperation With Wrongdoing
Latham S. Moral Distress and Cooperation With Wrongdoing. The American Journal Of Bioethics 2016, 16: 31-32. PMID: 27901422, DOI: 10.1080/15265161.2016.1240505.Peer-Reviewed Original Research
2015
The Author Replies
Latham S. The Author Replies. The Hastings Center Report 2015, 45: 3-4. PMID: 26413755, DOI: 10.1002/hast.480.Peer-Reviewed Original Research“Aid in Dying” in the Courts
Latham S. “Aid in Dying” in the Courts. The Hastings Center Report 2015, 45: 11-12. PMID: 25944201, DOI: 10.1002/hast.443.Peer-Reviewed Original ResearchProfessionalization of Clinical Ethics Consultation: Defining (Down) the Code
Latham S. Professionalization of Clinical Ethics Consultation: Defining (Down) the Code. The American Journal Of Bioethics 2015, 15: 54-56. PMID: 25970394, DOI: 10.1080/15265161.2015.1026235.Peer-Reviewed Original ResearchFacilitated Discussion: Good and Good for You
Latham S. Facilitated Discussion: Good and Good for You. The American Journal Of Bioethics 2015, 15: 58-59. PMID: 25562234, DOI: 10.1080/15265161.2015.978625.Peer-Reviewed Original Research
2014
The Author Replies
Latham S. The Author Replies. The Hastings Center Report 2014, 44: 5-5. PMID: 24634036, DOI: 10.1002/hast.276.Peer-Reviewed Original Research
2013
Time to Decriminalize HIV Status
Latham S. Time to Decriminalize HIV Status. The Hastings Center Report 2013, 43: 12-13. PMID: 24092584, DOI: 10.1002/hast.205.Peer-Reviewed Original Research
2012
U.S. Law and Animal Experimentation: A Critical Primer
Latham S. U.S. Law and Animal Experimentation: A Critical Primer. The Hastings Center Report 2012, 42: s35-s39. PMID: 23138429, DOI: 10.1002/hast.107.Peer-Reviewed Original ResearchConceptsRegulatory structureSufficient scientific justificationUnnecessary animal sufferingU.S. lawCountry’s lawsRegulatory philosophyHumane treatmentMedical experimentationLawHistorical accidentAnimal sufferingUse of animalsUnited StatesScientific justificationParticular kindMedical researchJustificationObvious wayProponentsSubstantial changesCountriesAnimal experimentationStandardsPhilosophyImportant concern