Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M. Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry. Chemical Research In Toxicology 2008, 21: 2370-2378. PMID: 19053323, PMCID: PMC2630229, DOI: 10.1021/tx8002615.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMitomycin CCancer cellsMCF-7 human breast cancer cellsEMT6 cellsEMT6 mouse mammary tumor cellsHuman breast cancer cellsMCF-7 breast cancer cellsMouse mammary tumor cellsMammary tumor cellsMCF-7 cellsHuman fibroblastsMitomycin C treatmentTumor cellsReductive metabolitesDecarbamoyl mitomycin CNormal human fibroblasts