2024
Takotsubo cardiomyopathy and cardiogenic shock due to hypokalaemic rhabdomyolysis
Hwang E, Namburar S, Siegel M, Sanchez A. Takotsubo cardiomyopathy and cardiogenic shock due to hypokalaemic rhabdomyolysis. BMJ Case Reports 2024, 17: e261456. PMID: 39419603, DOI: 10.1136/bcr-2024-261456.Peer-Reviewed Original ResearchConceptsTakotsubo cardiomyopathyCardiogenic shockAssociated with Takotsubo cardiomyopathyConsistent with cardiogenic shockConsistent with takotsubo cardiomyopathyTriggers of takotsubo cardiomyopathyCentral venous oxygen saturationInfluence cardiac morbidityChronic idiopathic constipationLow central venous oxygen saturationST-segment elevationVenous oxygen saturationWorsening cardiomyopathyGlobal hypokinesisPrognostic significanceCardiac morbidityIdiopathic constipationSpiked helmet signSegment elevationECG patternOxygen saturationCardiomyopathyRhabdomyolysisEchocardiographyEating disorders
2022
Imaging in the Intensive Care Unit
Toy D, Siegel M, Rubinowitz A. Imaging in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2022, 43: 899-923. PMID: 36442475, DOI: 10.1055/s-0042-1750041.Peer-Reviewed Original ResearchConceptsICU patientsIll patientsPathologic disease statesInterstitial lung diseaseIntensive care unitCT pulmonary angiographySpecific clinical scenariosModality of choicePortable chest radiographsHospital courseRadiologic manifestationsCare unitPleural effusionPulmonary angiographyLung diseaseICU settingChest radiographsSmall pneumothoracesRadiographic examinationAdditional abnormalitiesPatientsClinical scenariosPatient careInvasive devicesDiagnostic accuracy
2021
Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Reflections on New Evidence on Crisis Standards of Care in the COVID-19 Pandemic. The Journal Of Clinical Ethics 2021, 32: 358-360. PMID: 34928864, DOI: 10.1086/jce2021324358.Commentaries, Editorials and LettersConceptsSOFA scoreBlack patientsCrisis standardsSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreAccurate prognostic scoresNext public health emergencyCOVID-19 patientsLife-saving medical resourcesMedical resourcesCOVID-19 pandemicSame scoring systemPublic health emergencyPrognostic scoreBody of evidenceRare casePatientsScoring systemTriage purposesAssessment scoresHealth emergencyCareHealthcare systemCOVID-19ScoresThe Other Side of Triage: When Access to Intensive Care Measures May Do More Harm than Good
Feder KJ, Zaidi D, Siegel MD. The Other Side of Triage: When Access to Intensive Care Measures May Do More Harm than Good. The American Journal Of Bioethics 2021, 21: 79-82. PMID: 34710018, DOI: 10.1080/15265161.2021.1980136.Peer-Reviewed Original ResearchChallenges in interpreting cytokine data in COVID-19 affect patient care and management
Wang SY, Takahashi T, Pine AB, Damsky WE, Simonov M, Zhang Y, Kieras E, Price CC, King BA, Siegel MD, Desir GV, Lee AI, Iwasaki A, Chun HJ. Challenges in interpreting cytokine data in COVID-19 affect patient care and management. PLOS Biology 2021, 19: e3001373. PMID: 34358229, PMCID: PMC8372945, DOI: 10.1371/journal.pbio.3001373.Peer-Reviewed Original Research
2020
Developing a Triage Protocol for the COVID-19 Pandemic: Allocating Scarce Medical Resources in a Public Health Emergency.
Tolchin B, Latham SR, Bruce L, Ferrante LE, Kraschel K, Jubanyik K, Hull SC, Herbst JL, Kapo J, Moritz ED, Hughes J, Siegel MD, Mercurio MR. Developing a Triage Protocol for the COVID-19 Pandemic: Allocating Scarce Medical Resources in a Public Health Emergency. The Journal Of Clinical Ethics 2020, 31: 303-317. PMID: 32991327, DOI: 10.1086/jce2020314303.Peer-Reviewed Original ResearchConceptsPublic health emergencyTriage protocolScarce medical resourcesYale New Haven Health SystemMedical resourcesEthical challengesHealth emergencyCOVID-19 pandemicAllocating Scarce Medical ResourcesFuture wavesMajor ethical challengesChronic comorbiditiesPregnant patientsSimilar public health emergenciesHealthcare workersTriage assessmentClinical judgmentCoronavirus diseaseHealth systemSocioeconomic disparitiesRole of ageCOVID-19Less needPublic discussionSecondary goalMaking Medical Treatment Decisions for Unrepresented Patients in the ICU. An Official American Thoracic Society/American Geriatrics Society Policy Statement
Pope TM, Bennett J, Carson SS, Cederquist L, Cohen AB, DeMartino ES, Godfrey DM, Goodman-Crews P, Kapp MB, Lo B, Magnus DC, Reinke LF, Shirley JL, Siegel MD, Stapleton RD, Sudore RL, Tarzian AJ, Thornton JD, Wicclair MR, Widera EW, White DB. Making Medical Treatment Decisions for Unrepresented Patients in the ICU. An Official American Thoracic Society/American Geriatrics Society Policy Statement. American Journal Of Respiratory And Critical Care Medicine 2020, 201: 1182-1192. PMID: 32412853, PMCID: PMC7233335, DOI: 10.1164/rccm.202003-0512st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnrepresented patientsFair processProcedural due processMedical treatment decisionsPolicy statementsElder lawDue processHealth lawProcedural safeguardsState lawsUndue influenceLawCritical care settingAppropriate balanceAdvance directivesEthical goalsTreatment decisionsAppropriate medical careDiligent searchCapacity assessmentPatient advocacyInstitutionsPolicy recommendationsLess oversightCare settings
2019
Antibiotics and the Yield of Blood Cultures: Sequence Matters.
Geer JH, Siegel MD. Antibiotics and the Yield of Blood Cultures: Sequence Matters. Annals Of Internal Medicine 2019, 171: 587-588. PMID: 31525773, DOI: 10.7326/m19-2489.Peer-Reviewed Original ResearchEvaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours?
Leder SB, Warner HL, Suiter DM, Young NO, Bhattacharya B, Siner JM, Davis KA, Maerz LL, Rosenbaum SH, Marshall PS, Pisani MA, Siegel MD, Brennan JJ, Schuster KM. Evaluation of Swallow Function Post-Extubation: Is It Necessary to Wait 24 Hours? Annals Of Otology Rhinology & Laryngology 2019, 128: 619-624. PMID: 30841709, DOI: 10.1177/0003489419836115.Peer-Reviewed Original ResearchConceptsIntensive care unitSwallow evaluationDifferent intensive care unitsRe-intubation rateYale Swallow ProtocolMajority of patientsPost-extubation dysphagiaIntubation durationNosocomial pneumoniaPost extubationLonger hospitalizationCare unitProspective InvestigationSwallow ProtocolSwallowingHoursDysphagiaHospitalizationIntubationPneumoniaPatientsIncidenceEvaluation
2018
Internal medicine trainees' knowledge and confidence in using the American Society of Hematology Choosing Wisely guidelines in hemostasis, thrombosis, and non-malignant hematology
Marshall AL, Jenkins S, Oxentenko AS, Lee AI, Siegel MD, Katz JT, Vyas JM, Del Valle J, Mikhael JR. Internal medicine trainees' knowledge and confidence in using the American Society of Hematology Choosing Wisely guidelines in hemostasis, thrombosis, and non-malignant hematology. PLOS ONE 2018, 13: e0197414. PMID: 29768480, PMCID: PMC5955511, DOI: 10.1371/journal.pone.0197414.Peer-Reviewed Original ResearchA Young Man With Hemoptysis and Cavitary Lung Lesions
Brady VA, Zinchuk AV, Siegel MD, Possick JD. A Young Man With Hemoptysis and Cavitary Lung Lesions. CHEST Journal 2018, 153: e85-e88. PMID: 29626974, PMCID: PMC6026285, DOI: 10.1016/j.chest.2017.09.018.Peer-Reviewed Case Reports and Technical NotesConceptsBacillus Calmette-Guérin (BCG) vaccineCavitary lung lesionsPrior cigarette smokingCalmette-Guérin vaccineHistory of alcoholIntermittent hemoptysisNight sweatsCigarette smokingMusculoskeletal symptomsLung lesionsMild fatigueDrug useWeight lossHemoptysisYoung menMenDyspneaRashMedicationsSmokingFeverVaccineLesionsSymptomsMonths
2017
Not “Out of Sight, Out of Mind”
Bournival N, Siegel MD, Akgün KM. Not “Out of Sight, Out of Mind”. Critical Care Medicine 2017, 45: 134-136. PMID: 27984282, DOI: 10.1097/ccm.0000000000002119.Peer-Reviewed Original Research
2015
Critical Care at the End of Life
Akgün KM, Kapo JM, Siegel MD. Critical Care at the End of Life. Seminars In Respiratory And Critical Care Medicine 2015, 36: 921-933. PMID: 26600274, DOI: 10.1055/s-0035-1565254.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPalliative care skillsPalliative care modelCare modelCare skillsBasic palliative care skillsComplex palliative care needsIntensive care unit admissionCare unit admissionPalliative care consultationPalliative care needsPalliative care domainsChronic life-limiting conditionsFamily-centered endLife-limiting conditionsPeer support groupsUnit admissionEnd of lifeICU patientsSymptom managementCare consultationsICU providersCritical careIndividual ICUsICUCare needsUse of the Blom Tracheotomy Tube with Suction Inner Cannula to Decontaminate Microorganisms from the Subglottic Space. A Proof of Concept
Rabach L, Siegel MD, Puchalski JT, Towle D, Follert M, Johnson KM, Rademaker AW, Leder SB. Use of the Blom Tracheotomy Tube with Suction Inner Cannula to Decontaminate Microorganisms from the Subglottic Space. A Proof of Concept. Annals Of The American Thoracic Society 2015, 12: 859-863. PMID: 25849332, DOI: 10.1513/annalsats.201501-010bc.Peer-Reviewed Original ResearchConceptsMechanical ventilationTracheotomy tubeSubglottic spaceInner cannulaNormal floraPulmonary complicationsSignificant reductionOngoing mechanical ventilationEndotracheal tube intubationSingle-center studyTube intubationIll patientsEndotracheal tubeICU adultsSputum samplesTracheotomyMicrobiologic analysisCannulaVentilationComplicationsWeeksPathogensDurationSupraTracheostomyBringing Specialties Together: The Power of Intra-Professional Teams
Bongiovanni T, Long T, Khan AM, Siegel MD. Bringing Specialties Together: The Power of Intra-Professional Teams. Journal Of Graduate Medical Education 2015, 7: 19-20. PMID: 26217416, PMCID: PMC4507920, DOI: 10.4300/jgme-d-14-00509.1.Peer-Reviewed Original ResearchAn Official American Thoracic Society Policy Statement: Managing Conscientious Objections in Intensive Care Medicine
Lewis-Newby M, Wicclair M, Pope T, Rushton C, Curlin F, Diekema D, Durrer D, Ehlenbach W, Gibson-Scipio W, Glavan B, Langer L, Manthous C, Rose C, Scardella A, Shanawani H, Siegel MD, Halpern SD, Truog RD, White DB. An Official American Thoracic Society Policy Statement: Managing Conscientious Objections in Intensive Care Medicine. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 219-227. PMID: 25590155, DOI: 10.1164/rccm.201410-1916st.Peer-Reviewed Original ResearchMeSH KeywordsAccess to InformationAdolescentAdultAgedAttitude of Health PersonnelBioethical IssuesChildConscienceDisclosureFemaleGuidelines as TopicHealth Services AccessibilityHumansInfantIntensive Care UnitsMaleMiddle AgedOrganizational PolicyPatient RightsPregnancyProfessional AutonomySocieties, MedicalUnited StatesWorkforceConceptsCritical care settingCare settingsConscientious objectionMedical servicesAmerican Thoracic Society StatementIntensive care unit cliniciansMoral integrityTimely accessIntensive care medicineHospital administratorsMultidisciplinary expert committeeAvailable medical servicesPolicy statementsSociety statementCare medicineAdult medicineClinician judgmentPatient accessPatient advocacyCliniciansPatientsDiverse working groupExcessive hardshipsInstitutional mechanismsMoral dialogue
2014
Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma
Gutiérrez A, Sauler M, Mitchell JM, Siegel MD, Trow TK, Bacchetta M, Fares WH. Unresolved pulmonary embolism leading to a diagnosis of pulmonary artery sarcoma. Heart & Lung 2014, 43: 574-576. PMID: 24928184, DOI: 10.1016/j.hrtlng.2014.05.006.Peer-Reviewed Case Reports and Technical NotesConceptsPulmonary artery sarcomaPulmonary embolismPresumed pulmonary embolismUnresolved pulmonary embolismCT pulmonary angiogramAnticoagulation treatmentProgressive symptomsPulmonary angiogramSurgical resectionPulmonary arteryPoor prognosisRare tumorAdditional imagingDifferential diagnosisProper diagnosisEmbolismSarcomaDiagnosisResectionPatientsDyspneaArteryPrognosisAngiogramsMetastasisRecurrent Hydrothorax and Surgical Diaphragmatic Repair
Argento A, Kim A, Knauert-Brown M, Boffa D, Siegel MD, Jafari B, Puchalski JT. Recurrent Hydrothorax and Surgical Diaphragmatic Repair. Journal Of Bronchology & Interventional Pulmonology 2014, 21: 150-153. PMID: 24739690, DOI: 10.1097/lbr.0000000000000047.Peer-Reviewed Case Reports and Technical NotesConceptsRecurrent hydrothoraxSurgical repairDiaphragmatic defectPeritoneal dialysisPleural effusionEnd-stage renal diseaseHepatitis C cirrhosisLarge pleural effusionBest treatment modalityIntra-abdominal processesLarge diaphragmatic defectsOptimal patient careDramatic clinical consequencesC cirrhosisRecurrent admissionsTension hydrothoraxDefinitive managementMedical therapyRenal diseaseMedical managementTube thoracostomyCardiac arrestDiaphragmatic repairTreatment modalitiesComplete resolution
2013
Penguins and Palliative Care
Kapo J, Siegel MD. Penguins and Palliative Care. Critical Care Medicine 2013, 41: 2443-2444. PMID: 24060776, DOI: 10.1097/ccm.0b013e31829136f3.Peer-Reviewed Original Research
2012
My turn and my right
Siegel M. My turn and my right. The Lancet 2012, 380: 1992. PMID: 23217863, DOI: 10.1016/s0140-6736(12)62152-7.Peer-Reviewed Original Research