2023
Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue
Kim S, Cho Y, Shin Y, Yu H, Chowdhury T, Kim S, Yi K, Choi C, Cha S, Park C, Ku J. Patient-derived glioblastoma cell lines with conserved genome profiles of the original tissue. Scientific Data 2023, 10: 448. PMID: 37438387, PMCID: PMC10338444, DOI: 10.1038/s41597-023-02365-y.Peer-Reviewed Original ResearchConceptsCell linesPatient-derived glioblastoma cell linesPatient-derived cell linesWhole exome sequencing datasetsExome sequencing datasetsGBM cell linesGlioblastoma cell linesSequence dataGenomic featuresLethal intracranial tumorSequencing technologiesSequencing datasetsMolecular markersWES datasetsGenome profilesMutational signaturesDruggable targetsNumber alterationsBiological credibilityGenomic profilesBiological platformMolecular characteristicsOriginal tissueTumor tissueGlioblastoma
2020
Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells
Kim S, Seo Y, Chowdhury T, Yu H, Lee C, Kim K, Kang H, Kim H, Park S, Kim K, Park C. Inhibition of MUC1 exerts cell-cycle arrest and telomerase suppression in glioblastoma cells. Scientific Reports 2020, 10: 18238. PMID: 33106534, PMCID: PMC7589558, DOI: 10.1038/s41598-020-75457-z.Peer-Reviewed Original ResearchConceptsRole of MUC1Epithelial-mesenchymal transitionMucin 1Cell cycle arrestMUC1 knockdownNormal brain tissueExpression levelsGrowth factor betaTERT expression levelsGBM cell linesOverall survivalTherapeutic targetOncological processHuman gliomasBrain tissueFactor betaMesenchymal transitionPhosphorylation of RB1Diverse cancersGlioblastomaTelomere maintenance mechanismAnticancer mechanismCell proliferationCycle arrestGlioblastoma cells