2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal models
2020
Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial
Shaikh N, Shope T, Hoberman A, Muniz G, Bhatnagar S, Nowalk A, Hickey R, Michaels M, Kearney D, Rockette H, Charron M, Lim R, Majd M, Shalaby-Rana E, Kurs-Lasky M, Cohen D, Wald E, Lockhart G, Pohl H, Martin J. Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial. Pediatric Nephrology 2020, 35: 2113-2120. PMID: 32556960, PMCID: PMC7529851, DOI: 10.1007/s00467-020-04622-3.Peer-Reviewed Original ResearchConceptsFebrile urinary tract infectionUrinary tract infectionAdjuvant systemic corticosteroidsKidney scarringSystemic corticosteroidsTract infectionsInitiate urinary tract infectionReducing kidney scarringEfficacy of corticosteroidsMethodsChildren aged 2Absolute risk reductionRandomized to corticosteroidsMonths to 6Statistically significant differencePlacebo groupAdjuvant corticosteroidsCorticosteroidsKidney scansPlaceboSignificant differenceAged 2ScarsKidneyInfectionMonthsReducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults.
Tabari A, Gee M, Singh R, Lim R, Nimkin K, Primak A, Schmidt B, Kalra M. Reducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults. American Journal Of Roentgenology 2020, 214: 1199-1205. PMID: 32286868, DOI: 10.2214/ajr.19.22231.Peer-Reviewed Original ResearchConceptsSingle-energy CTContrast material volumeDS-DECTDual-energy CTRadiation doseThird-generation dual-source CT scannerDual-source dual-energy CTDual-source CT scannerContrast volume reductionCT dose descriptorsMean patient ageApplications of dual-energy CTContrast medium volumeWeight-matched patientsYoung adultsReduce radiation doseLow radiation doseCohen's kappa testConsecutive childrenPatient ageRadiological findingsDose descriptorsPatient demographicsRetrospective studyKappa test
2019
Clinical significance of incidentally discovered renal cysts in pediatric patients
Botwin A, Phewplung T, Wu K, Lim R, Traum A, Gee M. Clinical significance of incidentally discovered renal cysts in pediatric patients. Abdominal Radiology 2019, 44: 2835-2840. PMID: 30972430, DOI: 10.1007/s00261-019-02017-z.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePediatric patientsRenal cystsFamily historyClinical significanceCyst groupRisk of autosomal dominant polycystic kidney diseaseDiagnosis of autosomal dominant polycystic kidney diseaseAssociated with higher incidenceMethodsA retrospective searchFollow-up imagingDominant polycystic kidney diseaseSearch of radiology reportsMaximum cyst diameterStatistically significant elevationPolycystic kidney diseaseNo malignancyRetrospective search of radiology reportsCyst evaluationBilateral cystsCyst sizeFollow-up studyCyst characteristicsCyst diameterImaging predictors
2018
Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability
Tajmir S, Lee H, Shailam R, Gale H, Nguyen J, Westra S, Lim R, Yune S, Gee M, Do S. Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability. Skeletal Radiology 2018, 48: 275-283. PMID: 30069585, DOI: 10.1007/s00256-018-3033-2.Peer-Reviewed Original ResearchConceptsBone age assessmentAutomated artificial intelligenceAI assistanceBone age radiographsConvolutional neural networkDeep learning algorithmsRoot mean square errorMean square errorPediatric radiologistsUtilization of AILearning algorithmsNeural networkArtificial intelligenceIntraclass correlation coefficientImproved performancePooled cohortRadiologist interpretationImaging studiesInter-rater variationAccuracyMetabolic disordersIncreased accuracyRadiologistsAge accuracyMeasures of accuracy
2015
Simplifying size-specific radiation dose estimates in pediatric CT.
Khawaja R, Singh S, Vettiyil B, Lim R, Gee M, Westra S, Kalra M. Simplifying size-specific radiation dose estimates in pediatric CT. American Journal Of Roentgenology 2015, 204: 167-76. PMID: 25539253, DOI: 10.2214/ajr.13.12191.Peer-Reviewed Original ResearchConceptsSize-specific dose estimateStatistically significant correlationDose estimatesBody weightTorso diameterSize-specific doseConsecutive CT examinationsMedian body weightPatient's body weightRadiation dose estimatesSignificant correlationPediatric CTCT examinationsEffective diameterIndividual patientsOverall body weightClinical settingPatientsDoseD(apChildrenAutomated softwareMeasured diameterBodyManual measurements
2014
[18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine
Cheney M, Chen Y, Lim R, Winrich B, Grosu A, Trofimov A, Depauw N, Shih H, Schwab J, Hornicek F, DeLaney T. [18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 1030-1036. PMID: 25539367, PMCID: PMC4280072, DOI: 10.1016/j.ijrobp.2014.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell HypoxiaChordomaFeasibility StudiesFemaleHumansMaleMiddle AgedMisonidazoleMultimodal ImagingNeoplasm Recurrence, LocalPhotonsPilot ProjectsPositron-Emission TomographyProspective StudiesProton TherapyRadiopharmaceuticalsRadiotherapy DosageRelative Biological EffectivenessSacrococcygeal RegionSpinal NeoplasmsTomography, X-Ray ComputedTumor BurdenConceptsHypoxic subvolumesGross tumor volumeFMISO PET/CTRadiation therapyLocal recurrenceTumor volumeSacrococcygeal spinePositron emission tomography/computed tomographyRT dose escalationStage T2 tumorsEmission tomography/computed tomographyStandardized uptake valueMedian follow-upTreatment of chordomasChanges to treatmentVisualization of tumor hypoxiaDose escalationT2 tumorsTomography/computed tomographyMetastatic diseaseRecurrent chordomaUptake valueClinical characteristicsTumor hypoxiaFollow-upDose reduction in pediatric abdominal CT: use of iterative reconstruction techniques across different CT platforms
Khawaja R, Singh S, Otrakji A, Padole A, Lim R, Nimkin K, Westra S, Kalra M, Gee M. Dose reduction in pediatric abdominal CT: use of iterative reconstruction techniques across different CT platforms. Pediatric Radiology 2014, 45: 1046-1055. PMID: 25427434, DOI: 10.1007/s00247-014-3235-2.Peer-Reviewed Original ResearchConceptsIterative reconstruction techniqueSinogram-affirmed iterative reconstructionAdaptive statistical iterative reconstructionModel-based iterative reconstructionPediatric abdominal CTDose reductionIterative reconstructionAbdominal CTAdaptive iterative dose reductionMagnitude of dose reductionIncreased image noiseStatistical iterative reconstructionAIDR 3DReconstruction techniqueCT examinationsCT scanImage noiseReconstruction algorithmClinical settingDosing potentialClinical applicationImage qualityRadiology communityReconstruction principleImage interpretation
2013
Relationship between radiologist training level and fluoroscopy time for voiding cystourethrography.
Lim R, Ali Khawaja R, Nimkin K, Sagar P, Shailam R, Gee M, Westra S. Relationship between radiologist training level and fluoroscopy time for voiding cystourethrography. American Journal Of Roentgenology 2013, 200: 645-51. PMID: 23436857, DOI: 10.2214/ajr.12.8902.Peer-Reviewed Original ResearchConceptsAverage fluoroscopy timeAttending pediatric radiologistPatient age groupsFirst-year residentsPediatric radiology fellowsFluoroscopy timeVoiding cystourethrographyTraining levelPediatric radiologistsSenior radiology residentsAge groupsSenior residentsNo significant differenceRadiology residentsFemale patientsMale patientsPatient sexRadiology fellowsMale to female ratioShorter fluoroscopy timeSignificant differenceRadiologist sexMale radiologistsRadiologist training levelFemale radiologists
2010
Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging
Hong T, Shammas A, Charron M, Zukotynski K, Drubach L, Lim R. Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging. Pediatric Radiology 2010, 41: 759-768. PMID: 21161205, DOI: 10.1007/s00247-010-1925-y.Peer-Reviewed Original ResearchIntranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography
Chung S, Lim R, Goldman R. Intranasal fentanyl versus placebo for pain in children during catheterization for voiding cystourethrography. Pediatric Radiology 2010, 40: 1236-1240. PMID: 20180109, DOI: 10.1007/s00247-009-1521-1.Peer-Reviewed Original ResearchConceptsStatistically significant differenceIN fentanylDecrease painFaces Pain Score-RevisedPediatric tertiary care centreDouble-blind randomized controlled trialPediatric tertiary centerSignificant differenceTertiary care centreYears of ageRandomized controlled trialsVoiding cystourethrographyIntranasal fentanylTertiary centerUrinary catheterVCUGCatheterizationCare centreFentanylPainControl groupChildren 4PlaceboSterile waterIntranasal
2008
Renal pyramid echogenicity in ureteropelvic junction obstruction: correlation between altered echogenicity and differential renal function
Chavhan G, Daneman A, Moineddin R, Lim R, Langlois V, Traubici J. Renal pyramid echogenicity in ureteropelvic junction obstruction: correlation between altered echogenicity and differential renal function. Pediatric Radiology 2008, 38: 1068. PMID: 18633607, DOI: 10.1007/s00247-008-0943-5.Peer-Reviewed Original ResearchConceptsDifferential renal functionLoss of corticomedullary differentiationUreteropelvic junction obstructionPoor renal functionCorticomedullary differentiationUreteropelvic junctionRenal functionGroup 1Risk ratioObstructed kidneyGroup 2Increased echogenicityGroup 3Technetium-99m mercaptoacetyltriglycineResultsIn group 1Fisher's exact testAbnormal echogenicityObstructive hydronephrosisExact testTechnetium-99Histological changesRenal pyramidsHigh-frequency transducersEchogenicityPatients
2007
Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain
Lim R, Fahey F, Drubach L, Connolly L, Treves S. Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain. Journal Of Pediatric Orthopaedics 2007, 27: 277-282. PMID: 17414009, DOI: 10.1097/bpo.0b013e31803409ba.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBack painYounger patientsPotential sources of back painSource of back painFluorine-18Evaluating young patientsRadiation dosimetryNaF PET scanEnhanced patient throughputPET scansApophyseal injuriesPainTechnetium-99Tracer administrationPatientsRadiation doseSkeletal abnormalitiesPET acquisitionEmission tomographySodium fluorideScintigraphyNinety-fourPatient throughputDosimetry