2008
To kill a tumor cell: the potential of proapoptotic receptor agonists
Ashkenazi A, Herbst RS. To kill a tumor cell: the potential of proapoptotic receptor agonists. Journal Of Clinical Investigation 2008, 118: 1979-1990. PMID: 18523647, PMCID: PMC2396896, DOI: 10.1172/jci34359.Peer-Reviewed Original ResearchConceptsProapoptotic receptor agonistsApo2L/TRAILReceptor agonistRecombinant human Apo2L/TRAILExtrinsic apoptosis pathwayPotential therapeutic interventionsNovel molecular biomarkersApoptosis pathwayAgonistic mAbConventional therapyPreclinical dataTherapeutic interventionsTumor cellsMolecular biomarkersAbnormal cellsLogical targetTherapyAgonistsCellsExciting opportunitiesTumorigenesisPatientsApoptosisPathway
1991
Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.
Herbst RS, Nielsch U, Sladek F, Lai E, Babiss LE, Darnell JE. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. The New Biologist 1991, 3: 289-96. PMID: 1878351.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminsAnimalsBase SequenceCCAAT-Enhancer-Binding ProteinsDNADNA-Binding ProteinsGene Expression RegulationHepatocyte Nuclear Factor 1Hepatocyte Nuclear Factor 1-alphaHepatocyte Nuclear Factor 1-betaHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHepatocyte Nuclear Factor 3-gammaHepatocyte Nuclear Factor 4LiverMolecular Sequence DataNuclear ProteinsOligonucleotidesPhosphoproteinsPrealbuminRatsRNA, MessengerTranscription FactorsTumor Cells, CulturedConceptsTranscription factorsHepatocyte-enriched transcription factorsDNA-binding proteinsTransthyretin gene expressionRegulation of genesDNA-binding activityRat hepatoma cell lineLevel of expressionTranscriptional activityGene expressionHepatoma cell lineDifferential regulationCellular concentrationGenesHepatoma cellsCell linesExpressionRegulationTransthyretin geneLFB1HNF4HNF3ProteinEBPDifferent rates